CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = V166del1

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp12	166	V166del1	V4558del1	del	gtA	gt-	9	5	0.555556	13936-13938
ORF1ab/nsp12	166	V166del1	V4558del1	del	Gta	-ta	9	4	0.444444	13936-13938

Details of the mutation V166del1 within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp12	166	V166del1	gtA	gt-	5	9	All	0.000001
ORF1ab/nsp12	166	V166del1	Gta	-ta	4	9	All	0.000001
ORF1ab/nsp12	166	V166del1	gtA	gt-	1	2	B.1.1.7	0.000001
ORF1ab/nsp12	166	V166del1	Gta	-ta	1	2	B.1.1.7	0.000001
ORF1ab/nsp12	166	V166del1	Gta	-ta	1	1	AY.44	0.000006
ORF1ab/nsp12	166	V166del1	gtA	gt-	1	1	B	0.000128
ORF1ab/nsp12	166	V166del1	Gta	-ta	1	1	B.1.177	0.000013
ORF1ab/nsp12	166	V166del1	gtA	gt-	1	1	B.1.2	0.000009
ORF1ab/nsp12	166	V166del1	gtA	gt-	1	1	B.55	0.00295
ORF1ab/nsp12	166	V166del1	Gta	-ta	1	1	C.30.1	0.006711
ORF1ab/nsp12	166	V166del1	gtA	gt-	1	1	P.1.1	0.000318

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.