CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = T246I

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12246T246IT4638InonsynaCcaTc127612680.9937314176-14178
ORF1ab/nsp12246T246IT4638InonsynaCCaTT127680.0062695914176-14178

Details of the mutation T246I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12246T246IaCcaTc12681276All0.000243
ORF1ab/nsp12246T246IaCCaTT81276All0.000002
ORF1ab/nsp12246T246IaCcaTc317317AY.40.000493
ORF1ab/nsp12246T246IaCcaTc109112B.1.1.70.000098
ORF1ab/nsp12246T246IaCCaTT3112B.1.1.70.000003
ORF1ab/nsp12246T246IaCcaTc5959B.1.617.20.000222
ORF1ab/nsp12246T246IaCcaTc5656AY.30.000557
ORF1ab/nsp12246T246IaCcaTc5656B.1.438.10.006007
ORF1ab/nsp12246T246IaCcaTc4848B.1.20.000423
ORF1ab/nsp12246T246IaCcaTc4646B.1.2790.023626
ORF1ab/nsp12246T246IaCcaTc4242AY.440.000256
ORF1ab/nsp12246T246IaCcaTc4040AY.250.000241
ORF1ab/nsp12246T246IaCcaTc3838B.1.4290.000894
ORF1ab/nsp12246T246IaCcaTc3131B.1.5750.009405
ORF1ab/nsp12246T246IaCcaTc2424B.10.00022
ORF1ab/nsp12246T246IaCcaTc1818B.1.10.000327
ORF1ab/nsp12246T246IaCcaTc1717AY.430.000075
ORF1ab/nsp12246T246IaCcaTc1717B.1.5950.004436
ORF1ab/nsp12246T246IaCcaTc1616A0.006192
ORF1ab/nsp12246T246IaCcaTc1414AY.1030.000087
ORF1ab/nsp12246T246IaCcaTc1414AY.260.000396
ORF1ab/nsp12246T246IaCcaTc1213AY.1000.000552
ORF1ab/nsp12246T246IaCCaTT113AY.1000.000046
ORF1ab/nsp12246T246IaCcaTc1212P.10.000189
ORF1ab/nsp12246T246IaCcaTc1111AY.1020.000292
ORF1ab/nsp12246T246IaCcaTc99B.1.1.2860.026087
ORF1ab/nsp12246T246IaCcaTc88AY.370.002528
ORF1ab/nsp12246T246IaCcaTc88B.1.1.2740.040404
ORF1ab/nsp12246T246IaCcaTc77AY.98.10.000339
ORF1ab/nsp12246T246IaCcaTc77B.1.2430.000487
ORF1ab/nsp12246T246IaCcaTc66AY.290.000095
ORF1ab/nsp12246T246IaCcaTc66AY.420.000241
ORF1ab/nsp12246T246IaCcaTc56AY.50.000103
ORF1ab/nsp12246T246IaCCaTT16AY.50.000021
ORF1ab/nsp12246T246IaCcaTc66AY.9.20.00022
ORF1ab/nsp12246T246IaCcaTc66B.1.1770.000079
ORF1ab/nsp12246T246IaCcaTc66B.1.4250.017964
ORF1ab/nsp12246T246IaCcaTc46B.1.4270.000202
ORF1ab/nsp12246T246IaCCaTT26B.1.4270.000101
ORF1ab/nsp12246T246IaCcaTc66P.1.170.000971
ORF1ab/nsp12246T246IaCcaTc55AY.1200.000186
ORF1ab/nsp12246T246IaCcaTc55AY.470.000156
ORF1ab/nsp12246T246IaCcaTc55AY.610.000524
ORF1ab/nsp12246T246IaCcaTc55B.1.2340.00066
ORF1ab/nsp12246T246IaCcaTc55B.1.5260.000118
ORF1ab/nsp12246T246IaCcaTc55B.1.5960.000436
ORF1ab/nsp12246T246IaCcaTc55C.360.004554
ORF1ab/nsp12246T246IaCcaTc55P.20.000933
ORF1ab/nsp12246T246IaCcaTc44AY.390.000099
ORF1ab/nsp12246T246IaCcaTc44AY.4.50.00043
ORF1ab/nsp12246T246IaCcaTc44AY.450.000487
ORF1ab/nsp12246T246IaCcaTc44B.1.36.170.001976
ORF1ab/nsp12246T246IaCcaTc44C.36.30.002269
ORF1ab/nsp12246T246IaCcaTc33A.2.50.001497
ORF1ab/nsp12246T246IaCcaTc33AY.1180.000188
ORF1ab/nsp12246T246IaCcaTc33AY.4.20.000065
ORF1ab/nsp12246T246IaCcaTc33AY.880.002653
ORF1ab/nsp12246T246IaCcaTc33B0.000383
ORF1ab/nsp12246T246IaCcaTc33B.1.1.3480.002389
ORF1ab/nsp12246T246IaCcaTc33B.1.1.4410.15
ORF1ab/nsp12246T246IaCcaTc23B.1.1.5190.000079
ORF1ab/nsp12246T246IaCCaTT13B.1.1.5190.00004
ORF1ab/nsp12246T246IaCcaTc33B.1.351.20.000908
ORF1ab/nsp12246T246IaCcaTc33B.1.3690.000856
ORF1ab/nsp12246T246IaCcaTc33B.1.5610.001191
ORF1ab/nsp12246T246IaCcaTc33B.1.5820.001472
ORF1ab/nsp12246T246IaCcaTc33B.6.60.002667
ORF1ab/nsp12246T246IaCcaTc22AY.1170.000169
ORF1ab/nsp12246T246IaCcaTc22AY.200.000078
ORF1ab/nsp12246T246IaCcaTc22AY.340.000194
ORF1ab/nsp12246T246IaCcaTc22AY.4.2.10.000298
ORF1ab/nsp12246T246IaCcaTc22AY.410.000588
ORF1ab/nsp12246T246IaCcaTc22AY.460.000208
ORF1ab/nsp12246T246IaCcaTc22AY.980.000158
ORF1ab/nsp12246T246IaCcaTc22B.1.1.2980.001724
ORF1ab/nsp12246T246IaCcaTc22B.1.177.20.009091
ORF1ab/nsp12246T246IaCcaTc22B.1.2400.000431
ORF1ab/nsp12246T246IaCcaTc22B.1.3110.000549
ORF1ab/nsp12246T246IaCcaTc22B.1.36.180.00084
ORF1ab/nsp12246T246IaCcaTc22B.1.5970.009259
ORF1ab/nsp12246T246IaCcaTc22C.300.003454
ORF1ab/nsp12246T246IaCcaTc11A.20.000662
ORF1ab/nsp12246T246IaCcaTc11A.2.40.003367
ORF1ab/nsp12246T246IaCcaTc11AY.1100.000113
ORF1ab/nsp12246T246IaCcaTc11AY.1130.000142
ORF1ab/nsp12246T246IaCcaTc11AY.1160.000287
ORF1ab/nsp12246T246IaCcaTc11AY.130.000161
ORF1ab/nsp12246T246IaCcaTc11AY.140.000088
ORF1ab/nsp12246T246IaCcaTc11AY.160.00038
ORF1ab/nsp12246T246IaCcaTc11AY.230.00007
ORF1ab/nsp12246T246IaCcaTc11AY.23.10.000417
ORF1ab/nsp12246T246IaCcaTc11AY.270.000065
ORF1ab/nsp12246T246IaCcaTc11AY.280.00189
ORF1ab/nsp12246T246IaCcaTc11AY.300.000396
ORF1ab/nsp12246T246IaCcaTc11AY.39.10.00004
ORF1ab/nsp12246T246IaCcaTc11AY.620.000436
ORF1ab/nsp12246T246IaCcaTc11AY.680.000274
ORF1ab/nsp12246T246IaCcaTc11AY.7.10.000113
ORF1ab/nsp12246T246IaCcaTc11AY.750.000056
ORF1ab/nsp12246T246IaCcaTc11AY.840.000437
ORF1ab/nsp12246T246IaCcaTc11AY.9.10.000084
ORF1ab/nsp12246T246IaCcaTc11AY.920.000287
ORF1ab/nsp12246T246IaCcaTc11AY.99.20.000092
ORF1ab/nsp12246T246IaCcaTc11B.1.1.2070.001182
ORF1ab/nsp12246T246IaCcaTc11B.1.1.2220.000204
ORF1ab/nsp12246T246IaCcaTc11B.1.1.2550.00303
ORF1ab/nsp12246T246IaCcaTc11B.1.1.2800.003086
ORF1ab/nsp12246T246IaCcaTc11B.1.1.3070.002532
ORF1ab/nsp12246T246IaCcaTc11B.1.1.3110.000358
ORF1ab/nsp12246T246IaCcaTc11B.1.1.3180.000302
ORF1ab/nsp12246T246IaCcaTc11B.1.1.3440.010753
ORF1ab/nsp12246T246IaCcaTc11B.1.1.3780.007299
ORF1ab/nsp12246T246IaCcaTc11B.1.1.390.00051
ORF1ab/nsp12246T246IaCcaTc11B.1.1.4650.015625
ORF1ab/nsp12246T246IaCcaTc11B.1.1.50.008333
ORF1ab/nsp12246T246IaCcaTc11B.1.1.700.000341
ORF1ab/nsp12246T246IaCcaTc11B.1.1470.000756
ORF1ab/nsp12246T246IaCcaTc11B.1.1600.000031
ORF1ab/nsp12246T246IaCcaTc11B.1.177.40.000211
ORF1ab/nsp12246T246IaCcaTc11B.1.177.450.000381
ORF1ab/nsp12246T246IaCcaTc11B.1.177.750.001041
ORF1ab/nsp12246T246IaCcaTc11B.1.2210.000071
ORF1ab/nsp12246T246IaCcaTc11B.1.2520.006623
ORF1ab/nsp12246T246IaCcaTc11B.1.2580.000067
ORF1ab/nsp12246T246IaCcaTc11B.1.3360.002439
ORF1ab/nsp12246T246IaCcaTc11B.1.3510.00003
ORF1ab/nsp12246T246IaCcaTc11B.1.36.10.00114
ORF1ab/nsp12246T246IaCcaTc11B.1.36.100.004785
ORF1ab/nsp12246T246IaCcaTc11B.1.36.310.001751
ORF1ab/nsp12246T246IaCcaTc11B.1.3750.00082
ORF1ab/nsp12246T246IaCcaTc11B.1.4000.000429
ORF1ab/nsp12246T246IaCcaTc11B.1.4040.001302
ORF1ab/nsp12246T246IaCcaTc11B.1.4160.001269
ORF1ab/nsp12246T246IaCcaTc11B.1.5250.000113
ORF1ab/nsp12246T246IaCcaTc11B.1.5810.009434
ORF1ab/nsp12246T246IaCcaTc11B.1.6090.000479
ORF1ab/nsp12246T246IaCcaTc11B.1.617.10.000129
ORF1ab/nsp12246T246IaCcaTc11B.1.6200.000946
ORF1ab/nsp12246T246IaCcaTc11B.1.6270.00202
ORF1ab/nsp12246T246IaCcaTc11D.20.000075
ORF1ab/nsp12246T246IaCcaTc11P.1.100.000269
ORF1ab/nsp12246T246IaCcaTc11P.1.150.000232

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.