CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = R285C

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12285R285CR4677CnonsynCgtTgt3923910.99744914293-14295
ORF1ab/nsp12285R285CR4677CnonsynCgTTgC39210.0025510214293-14295

Details of the mutation R285C within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12285R285CCgtTgt391392All0.000075
ORF1ab/nsp12285R285CCgTTgC1392All0
ORF1ab/nsp12285R285CCgtTgt7171B.1.1.70.000064
ORF1ab/nsp12285R285CCgtTgt5050B.1.1.5190.001986
ORF1ab/nsp12285R285CCgtTgt3737AY.40.000058
ORF1ab/nsp12285R285CCgtTgt2525B.1.4290.000588
ORF1ab/nsp12285R285CCgtTgt2222B.1.617.20.000083
ORF1ab/nsp12285R285CCgtTgt2020B.1.20.000176
ORF1ab/nsp12285R285CCgtTgt2020P.10.000315
ORF1ab/nsp12285R285CCgtTgt1010B.1.6370.000731
ORF1ab/nsp12285R285CCgtTgt88AY.440.000049
ORF1ab/nsp12285R285CCgtTgt77AY.250.000042
ORF1ab/nsp12285R285CCgtTgt66AY.1180.000376
ORF1ab/nsp12285R285CCgtTgt66B.1.1.1700.007481
ORF1ab/nsp12285R285CCgtTgt55AY.200.000194
ORF1ab/nsp12285R285CCgtTgt55B.1.177.820.002387
ORF1ab/nsp12285R285CCgtTgt55B.1.2650.006353
ORF1ab/nsp12285R285CCgtTgt55B.1.5260.000118
ORF1ab/nsp12285R285CCgtTgt44AY.430.000018
ORF1ab/nsp12285R285CCgtTgt44B.10.000037
ORF1ab/nsp12285R285CCgtTgt33AY.1030.000019
ORF1ab/nsp12285R285CCgtTgt33AY.290.000047
ORF1ab/nsp12285R285CCgtTgt33AY.470.000093
ORF1ab/nsp12285R285CCgtTgt33AY.730.001996
ORF1ab/nsp12285R285CCgtTgt33AY.750.000168
ORF1ab/nsp12285R285CCgtTgt33B.1.10.000054
ORF1ab/nsp12285R285CCgTTgC120.055556
ORF1ab/nsp12285R285CCgtTgt120.055556
ORF1ab/nsp12285R285CCgtTgt22A.280.005291
ORF1ab/nsp12285R285CCgtTgt22AY.1000.000092
ORF1ab/nsp12285R285CCgtTgt22AY.30.00002
ORF1ab/nsp12285R285CCgtTgt22AY.390.000049
ORF1ab/nsp12285R285CCgtTgt22AY.460.000208
ORF1ab/nsp12285R285CCgtTgt22B.1.1.2530.005013
ORF1ab/nsp12285R285CCgtTgt22B.1.1600.000062
ORF1ab/nsp12285R285CCgtTgt22B.1.1770.000026
ORF1ab/nsp12285R285CCgtTgt11A0.000387
ORF1ab/nsp12285R285CCgtTgt11A.2.40.003367
ORF1ab/nsp12285R285CCgtTgt11AY.100.00053
ORF1ab/nsp12285R285CCgtTgt11AY.1060.000335
ORF1ab/nsp12285R285CCgtTgt11AY.1070.000466
ORF1ab/nsp12285R285CCgtTgt11AY.110.001339
ORF1ab/nsp12285R285CCgtTgt11AY.1110.000183
ORF1ab/nsp12285R285CCgtTgt11AY.1190.000035
ORF1ab/nsp12285R285CCgtTgt11AY.120.10.000321
ORF1ab/nsp12285R285CCgtTgt11AY.140.000088
ORF1ab/nsp12285R285CCgtTgt11AY.230.00007
ORF1ab/nsp12285R285CCgtTgt11AY.23.10.000417
ORF1ab/nsp12285R285CCgtTgt11AY.260.000028
ORF1ab/nsp12285R285CCgtTgt11AY.300.000396
ORF1ab/nsp12285R285CCgtTgt11AY.320.000532
ORF1ab/nsp12285R285CCgtTgt11AY.420.00004
ORF1ab/nsp12285R285CCgtTgt11AY.450.000122
ORF1ab/nsp12285R285CCgtTgt11AY.46.40.000165
ORF1ab/nsp12285R285CCgtTgt11AY.50.000021
ORF1ab/nsp12285R285CCgtTgt11AY.740.000116
ORF1ab/nsp12285R285CCgtTgt11AY.9.20.000037
ORF1ab/nsp12285R285CCgtTgt11AY.950.000761
ORF1ab/nsp12285R285CCgtTgt11AY.980.000079
ORF1ab/nsp12285R285CCgtTgt11AY.99.20.000092
ORF1ab/nsp12285R285CCgtTgt11B.1.1.280.000311
ORF1ab/nsp12285R285CCgtTgt11B.1.1.3110.000358
ORF1ab/nsp12285R285CCgtTgt11B.1.1.3980.003226
ORF1ab/nsp12285R285CCgtTgt11B.1.177.210.000076
ORF1ab/nsp12285R285CCgtTgt11B.1.177.730.000566
ORF1ab/nsp12285R285CCgtTgt11B.1.2390.001221
ORF1ab/nsp12285R285CCgtTgt11B.1.258.170.000104
ORF1ab/nsp12285R285CCgtTgt11B.1.360.000146
ORF1ab/nsp12285R285CCgtTgt11B.1.3910.001127
ORF1ab/nsp12285R285CCgtTgt11B.1.4040.001302
ORF1ab/nsp12285R285CCgtTgt11B.1.416.10.001563
ORF1ab/nsp12285R285CCgtTgt11B.1.4270.00005
ORF1ab/nsp12285R285CCgtTgt11B.1.466.20.000391
ORF1ab/nsp12285R285CCgtTgt11B.1.4970.000315
ORF1ab/nsp12285R285CCgtTgt11B.1.5510.00129
ORF1ab/nsp12285R285CCgtTgt11B.1.5950.000261
ORF1ab/nsp12285R285CCgtTgt11B.400.000364
ORF1ab/nsp12285R285CCgtTgt11C.370.000116
ORF1ab/nsp12285R285CCgtTgt11D.20.000075
ORF1ab/nsp12285R285CCgtTgt11P.1.150.000232
ORF1ab/nsp12285R285CCgtTgt11Q.10.000126
ORF1ab/nsp12285R285CCgtTgt11Q.30.000145

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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