CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = R173C

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12173R173CR4565CnonsynCgcTgc289228910.99965413957-13959
ORF1ab/nsp12173R173CR4565CnonsynCgCTgT289210.00034578113957-13959

Details of the mutation R173C within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12173R173CCgcTgc28912892All0.000553
ORF1ab/nsp12173R173CCgCTgT12892All0
ORF1ab/nsp12173R173CCgcTgc998998B.1.438.10.107047
ORF1ab/nsp12173R173CCgcTgc269269AY.40.000419
ORF1ab/nsp12173R173CCgcTgc235235B.1.5750.071299
ORF1ab/nsp12173R173CCgcTgc196196B.1.6120.519894
ORF1ab/nsp12173R173CCgcTgc148148AY.250.00089
ORF1ab/nsp12173R173CCgcTgc110111B.1.617.20.000414
ORF1ab/nsp12173R173CCgCTgT1111B.1.617.20.000004
ORF1ab/nsp12173R173CCgcTgc106106AY.1030.000658
ORF1ab/nsp12173R173CCgcTgc8989AY.39.10.003526
ORF1ab/nsp12173R173CCgcTgc7575B.1.1.70.000067
ORF1ab/nsp12173R173CCgcTgc5858AY.20.020655
ORF1ab/nsp12173R173CCgcTgc4646B.1.10.000834
ORF1ab/nsp12173R173CCgcTgc4343B.1.36.350.111979
ORF1ab/nsp12173R173CCgcTgc4040AY.440.000243
ORF1ab/nsp12173R173CCgcTgc3737B.10.000339
ORF1ab/nsp12173R173CCgcTgc3131AY.430.000137
ORF1ab/nsp12173R173CCgcTgc2929AY.30.000288
ORF1ab/nsp12173R173CCgcTgc2020B.1.1770.000263
ORF1ab/nsp12173R173CCgcTgc1818AY.200.0007
ORF1ab/nsp12173R173CCgcTgc1414B.1.20.000123
ORF1ab/nsp12173R173CCgcTgc1212AY.290.000189
ORF1ab/nsp12173R173CCgcTgc1212B.1.1.5190.000477
ORF1ab/nsp12173R173CCgcTgc1212C.370.001393
ORF1ab/nsp12173R173CCgcTgc1111AY.270.000712
ORF1ab/nsp12173R173CCgcTgc1010AY.1000.00046
ORF1ab/nsp12173R173CCgcTgc1010AY.260.000283
ORF1ab/nsp12173R173CCgcTgc1010R.10.0009
ORF1ab/nsp12173R173CCgcTgc99B.1.2410.007305
ORF1ab/nsp12173R173CCgcTgc88AY.910.005844
ORF1ab/nsp12173R173CCgcTgc77AY.390.000173
ORF1ab/nsp12173R173CCgcTgc77AY.4.20.000152
ORF1ab/nsp12173R173CCgcTgc77AY.50.000145
ORF1ab/nsp12173R173CCgcTgc77AY.99.20.000645
ORF1ab/nsp12173R173CCgcTgc66AY.230.000418
ORF1ab/nsp12173R173CCgcTgc66B.1.2430.000418
ORF1ab/nsp12173R173CCgcTgc66P.1.140.000287
ORF1ab/nsp12173R173CCgcTgc55AY.1020.000133
ORF1ab/nsp12173R173CCgcTgc55AY.330.000334
ORF1ab/nsp12173R173CCgcTgc55AY.46.40.000823
ORF1ab/nsp12173R173CCgcTgc55B.1.1.2430.020408
ORF1ab/nsp12173R173CCgcTgc55B.1.4270.000252
ORF1ab/nsp12173R173CCgcTgc55D.20.000375
ORF1ab/nsp12173R173CCgcTgc55P.1.160.001871
ORF1ab/nsp12173R173CCgcTgc44AY.1130.00057
ORF1ab/nsp12173R173CCgcTgc44AY.1180.000251
ORF1ab/nsp12173R173CCgcTgc44AY.160.001519
ORF1ab/nsp12173R173CCgcTgc44AY.60.000165
ORF1ab/nsp12173R173CCgcTgc44B.1.1.2140.000222
ORF1ab/nsp12173R173CCgcTgc44B.1.177.520.00703
ORF1ab/nsp12173R173CCgcTgc44B.1.2210.000284
ORF1ab/nsp12173R173CCgcTgc44P.10.000063
ORF1ab/nsp12173R173CCgcTgc33AY.10.001187
ORF1ab/nsp12173R173CCgcTgc33AY.300.001187
ORF1ab/nsp12173R173CCgcTgc33AY.470.000093
ORF1ab/nsp12173R173CCgcTgc33AY.90.000203
ORF1ab/nsp12173R173CCgcTgc33B0.000383
ORF1ab/nsp12173R173CCgcTgc33B.1.4290.000071
ORF1ab/nsp12173R173CCgcTgc33B.1.5260.000071
ORF1ab/nsp12173R173CCgcTgc33B.1.564.10.004732
ORF1ab/nsp12173R173CCgcTgc33B.1.5820.001472
ORF1ab/nsp12173R173CCgcTgc33B.1.5960.000261
ORF1ab/nsp12173R173CCgcTgc22AY.1190.000071
ORF1ab/nsp12173R173CCgcTgc22AY.1200.000074
ORF1ab/nsp12173R173CCgcTgc22AY.16.10.00094
ORF1ab/nsp12173R173CCgcTgc22AY.5.40.000553
ORF1ab/nsp12173R173CCgcTgc22AY.590.001059
ORF1ab/nsp12173R173CCgcTgc22AY.850.000854
ORF1ab/nsp12173R173CCgcTgc22AY.980.000158
ORF1ab/nsp12173R173CCgcTgc22B.1.1.10.000653
ORF1ab/nsp12173R173CCgcTgc22B.1.1.2160.001781
ORF1ab/nsp12173R173CCgcTgc22B.1.1.2220.000408
ORF1ab/nsp12173R173CCgcTgc22B.1.1280.001271
ORF1ab/nsp12173R173CCgcTgc22B.1.2060.001631
ORF1ab/nsp12173R173CCgcTgc22B.1.4380.013072
ORF1ab/nsp12173R173CCgcTgc22B.1.4990.002101
ORF1ab/nsp12173R173CCgcTgc22B.1.5680.002222
ORF1ab/nsp12173R173CCgcTgc22B.1.6210.000177
ORF1ab/nsp12173R173CCgcTgc22B.1.6370.000146
ORF1ab/nsp12173R173CCgcTgc11A.280.002646
ORF1ab/nsp12173R173CCgcTgc11AY.1010.00049
ORF1ab/nsp12173R173CCgcTgc11AY.1100.000113
ORF1ab/nsp12173R173CCgcTgc11AY.120.000316
ORF1ab/nsp12173R173CCgcTgc11AY.120.10.000321
ORF1ab/nsp12173R173CCgcTgc11AY.1210.000135
ORF1ab/nsp12173R173CCgcTgc11AY.140.000088
ORF1ab/nsp12173R173CCgcTgc11AY.220.002092
ORF1ab/nsp12173R173CCgcTgc11AY.23.10.000417
ORF1ab/nsp12173R173CCgcTgc11AY.4.40.000409
ORF1ab/nsp12173R173CCgcTgc11AY.420.00004
ORF1ab/nsp12173R173CCgcTgc11AY.460.000104
ORF1ab/nsp12173R173CCgcTgc11AY.46.60.000072
ORF1ab/nsp12173R173CCgcTgc11AY.530.000288
ORF1ab/nsp12173R173CCgcTgc11AY.540.000095
ORF1ab/nsp12173R173CCgcTgc11AY.610.000105
ORF1ab/nsp12173R173CCgcTgc11AY.620.000436
ORF1ab/nsp12173R173CCgcTgc11AY.670.000464
ORF1ab/nsp12173R173CCgcTgc11AY.680.000274
ORF1ab/nsp12173R173CCgcTgc11AY.730.000665
ORF1ab/nsp12173R173CCgcTgc11AY.740.000116
ORF1ab/nsp12173R173CCgcTgc11AY.75.10.00018
ORF1ab/nsp12173R173CCgcTgc11AY.840.000437
ORF1ab/nsp12173R173CCgcTgc11AY.920.000287
ORF1ab/nsp12173R173CCgcTgc11AY.960.002075
ORF1ab/nsp12173R173CCgcTgc11AY.98.10.000048
ORF1ab/nsp12173R173CCgcTgc11AY.990.001049
ORF1ab/nsp12173R173CCgcTgc11B.1.1.280.000311
ORF1ab/nsp12173R173CCgcTgc11B.1.1.2910.000742
ORF1ab/nsp12173R173CCgcTgc11B.1.1.3010.001179
ORF1ab/nsp12173R173CCgcTgc11B.1.1.3260.001761
ORF1ab/nsp12173R173CCgcTgc11B.1.1.330.000421
ORF1ab/nsp12173R173CCgcTgc11B.1.1.3430.020833
ORF1ab/nsp12173R173CCgcTgc11B.1.1.3880.045455
ORF1ab/nsp12173R173CCgcTgc11B.1.1.4060.006494
ORF1ab/nsp12173R173CCgcTgc11B.1.1.4340.000349
ORF1ab/nsp12173R173CCgcTgc11B.1.1.630.000386
ORF1ab/nsp12173R173CCgcTgc11B.1.110.30.000718
ORF1ab/nsp12173R173CCgcTgc11B.1.177.600.000218
ORF1ab/nsp12173R173CCgcTgc11B.1.177.810.000189
ORF1ab/nsp12173R173CCgcTgc11B.1.2340.000132
ORF1ab/nsp12173R173CCgcTgc11B.1.2580.000067
ORF1ab/nsp12173R173CCgcTgc11B.1.36.270.000763
ORF1ab/nsp12173R173CCgcTgc11B.1.36.290.000517
ORF1ab/nsp12173R173CCgcTgc11B.1.3600.012658
ORF1ab/nsp12173R173CCgcTgc11B.1.3770.004566
ORF1ab/nsp12173R173CCgcTgc11B.1.416.10.001563
ORF1ab/nsp12173R173CCgcTgc11B.1.4220.000812
ORF1ab/nsp12173R173CCgcTgc11B.1.4530.003236
ORF1ab/nsp12173R173CCgcTgc11B.1.5610.000397
ORF1ab/nsp12173R173CCgcTgc11B.1.5770.000687
ORF1ab/nsp12173R173CCgcTgc11B.1.6230.000536
ORF1ab/nsp12173R173CCgcTgc11B.530.011765
ORF1ab/nsp12173R173CCgcTgc11B.610.005747
ORF1ab/nsp12173R173CCgcTgc11C.380.008065
ORF1ab/nsp12173R173CCgcTgc11N.10.016949
ORF1ab/nsp12173R173CCgcTgc11P.1.150.000232
ORF1ab/nsp12173R173CCgcTgc11Q.80.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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