CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = P612H

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12612P612HP5004HnonsyncCtcAt21200.95238115274-15276
ORF1ab/nsp12612P612HP5004HnonsyncCTcAC2110.04761915274-15276

Details of the mutation P612H within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12612P612HcCtcAt2021All0.000004
ORF1ab/nsp12612P612HcCTcAC121All0
ORF1ab/nsp12612P612HcCtcAt77AY.40.000011
ORF1ab/nsp12612P612HcCtcAt33B.10.000027
ORF1ab/nsp12612P612HcCTcAC12B.1.1.70.000001
ORF1ab/nsp12612P612HcCtcAt12B.1.1.70.000001
ORF1ab/nsp12612P612HcCtcAt11AY.1200.000037
ORF1ab/nsp12612P612HcCtcAt11AY.240.000431
ORF1ab/nsp12612P612HcCtcAt11AY.4.20.000022
ORF1ab/nsp12612P612HcCtcAt11AY.60.000041
ORF1ab/nsp12612P612HcCtcAt11B0.000128
ORF1ab/nsp12612P612HcCtcAt11B.1.1.700.000341
ORF1ab/nsp12612P612HcCtcAt11B.1.1770.000013
ORF1ab/nsp12612P612HcCtcAt11B.60.00091
ORF1ab/nsp12612P612HcCtcAt11B.6.60.000889

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.