CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = M906I
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp12 | 906 | M906I | M5298I | nonsyn | atG | atT | 526 | 514 | 0.977186 | 16156-16158 |
| ORF1ab/nsp12 | 906 | M906I | M5298I | nonsyn | atG | atA | 526 | 9 | 0.0171103 | 16156-16158 |
| ORF1ab/nsp12 | 906 | M906I | M5298I | nonsyn | atG | atC | 526 | 3 | 0.00570342 | 16156-16158 |
Details of the mutation M906I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 514 | 526 | All | 0.000098 |
| ORF1ab/nsp12 | 906 | M906I | atG | atA | 9 | 526 | All | 0.000002 |
| ORF1ab/nsp12 | 906 | M906I | atG | atC | 3 | 526 | All | 0.000001 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 225 | 228 | B.1.1.7 | 0.000201 |
| ORF1ab/nsp12 | 906 | M906I | atG | atA | 2 | 228 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp12 | 906 | M906I | atG | atC | 1 | 228 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 36 | 36 | AY.99.2 | 0.003318 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 34 | 34 | B.1.160.13 | 0.944444 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 27 | 27 | B.1.258 | 0.001797 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 9 | 13 | B.1.2 | 0.000079 |
| ORF1ab/nsp12 | 906 | M906I | atG | atA | 3 | 13 | B.1.2 | 0.000026 |
| ORF1ab/nsp12 | 906 | M906I | atG | atC | 1 | 13 | B.1.2 | 0.000009 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 12 | 12 | B.1.1.214 | 0.000665 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 11 | 11 | B.1.160 | 0.000343 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 7 | 8 | AY.44 | 0.000043 |
| ORF1ab/nsp12 | 906 | M906I | atG | atA | 1 | 8 | AY.44 | 0.000006 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 8 | 8 | B.1.177 | 0.000105 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 8 | 8 | B.1.36 | 0.001167 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 7 | 7 | AY.25 | 0.000042 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 7 | 7 | B.1 | 0.000064 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 6 | 6 | AY.4 | 0.000009 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 6 | 6 | P.1 | 0.000095 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 5 | 5 | B.1.177.86 | 0.000917 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 5 | 5 | B.1.617.2 | 0.000019 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 5 | 5 | B.1.637 | 0.000365 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 4 | 4 | AY.43 | 0.000018 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 4 | 4 | B.1.525 | 0.000453 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 3 | 3 | AY.103 | 0.000019 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 3 | 3 | AY.118 | 0.000188 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 3 | 3 | B.1.1 | 0.000054 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 3 | 3 | B.1.1.27 | 0.016949 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 3 | B.1.1.28 | 0.000622 |
| ORF1ab/nsp12 | 906 | M906I | atG | atA | 1 | 3 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 3 | 3 | B.1.1.284 | 0.000322 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 3 | 3 | B.1.189 | 0.012876 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 3 | 3 | B.1.243 | 0.000209 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 3 | 3 | B.1.617.1 | 0.000387 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | A | 0.000774 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | AY.120 | 0.000074 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | AY.26 | 0.000057 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | AY.29 | 0.000032 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | B.1.1.375 | 0.02381 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | B.1.177.33 | 0.003289 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | B.1.177.7 | 0.00033 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | B.1.311 | 0.000549 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | B.1.320 | 0.002491 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | B.1.369 | 0.00057 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | B.1.438.1 | 0.000215 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | C.37 | 0.000232 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 2 | 2 | N.4 | 0.008511 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | A.23.1 | 0.000704 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.102 | 0.000027 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.120.2 | 0.001285 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.16 | 0.00038 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.3 | 0.00001 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.69 | 0.000187 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | AY.9.1 | 0.000084 |
| ORF1ab/nsp12 | 906 | M906I | atG | atA | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.222 | 0.000204 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.25 | 0.000569 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.269 | 0.001353 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.280 | 0.003086 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.312 | 0.001912 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.33 | 0.000421 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.351 | 0.002793 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.372 | 0.000689 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.432 | 0.001266 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.46 | 0.004367 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.1.50 | 0.000679 |
| ORF1ab/nsp12 | 906 | M906I | atG | atC | 1 | 1 | B.1.1.8 | 0.003584 |
| ORF1ab/nsp12 | 906 | M906I | atG | atA | 1 | 1 | B.1.177.44 | 0.000519 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.177.6 | 0.000977 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.258.11 | 0.000396 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.338 | 0.008621 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.442 | 0.035714 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.497 | 0.000315 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.564 | 0.000426 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp12 | 906 | M906I | atG | atT | 1 | 1 | P.3 | 0.001595 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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