CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = M666I

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12666M666IM5058InonsynatGatT631160060.95167215436-15438
ORF1ab/nsp12666M666IM5058InonsynatGatA63112530.040088715436-15438
ORF1ab/nsp12666M666IM5058InonsynatGatC6311520.0082395815436-15438

Details of the mutation M666I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12666M666IatGatT60066311All0.001149
ORF1ab/nsp12666M666IatGatA2536311All0.000048
ORF1ab/nsp12666M666IatGatC526311All0.00001
ORF1ab/nsp12666M666IatGatT23152315B.1.36.180.972689
ORF1ab/nsp12666M666IatGatT14411441B.1.1.500.978276
ORF1ab/nsp12666M666IatGatT356356B.1.2230.988889
ORF1ab/nsp12666M666IatGatT248257B.10.002272
ORF1ab/nsp12666M666IatGatA8257B.10.000073
ORF1ab/nsp12666M666IatGatC1257B.10.000009
ORF1ab/nsp12666M666IatGatT255255B.1.4110.944444
ORF1ab/nsp12666M666IatGatT206237AY.30.002049
ORF1ab/nsp12666M666IatGatA31237AY.30.000308
ORF1ab/nsp12666M666IatGatT144230AY.40.000224
ORF1ab/nsp12666M666IatGatA86230AY.40.000134
ORF1ab/nsp12666M666IatGatT144163B.1.617.20.000542
ORF1ab/nsp12666M666IatGatA16163B.1.617.20.00006
ORF1ab/nsp12666M666IatGatC3163B.1.617.20.000011
ORF1ab/nsp12666M666IatGatT157157B.1.5320.975155
ORF1ab/nsp12666M666IatGatT8990B.1.1770.001172
ORF1ab/nsp12666M666IatGatC190B.1.1770.000013
ORF1ab/nsp12666M666IatGatT4561B.1.1.70.00004
ORF1ab/nsp12666M666IatGatC1261B.1.1.70.000011
ORF1ab/nsp12666M666IatGatA461B.1.1.70.000004
ORF1ab/nsp12666M666IatGatT4649B.1.20.000405
ORF1ab/nsp12666M666IatGatA349B.1.20.000026
ORF1ab/nsp12666M666IatGatT3147AY.430.000137
ORF1ab/nsp12666M666IatGatA1547AY.430.000066
ORF1ab/nsp12666M666IatGatC147AY.430.000004
ORF1ab/nsp12666M666IatGatT4040B.1.2430.002783
ORF1ab/nsp12666M666IatGatT3838B.1.5910.404255
ORF1ab/nsp12666M666IatGatT3838C.160.040297
ORF1ab/nsp12666M666IatGatT3636AY.840.015748
ORF1ab/nsp12666M666IatGatC2331AY.440.00014
ORF1ab/nsp12666M666IatGatT631AY.440.000037
ORF1ab/nsp12666M666IatGatA231AY.440.000012
ORF1ab/nsp12666M666IatGatT2629AY.200.00101
ORF1ab/nsp12666M666IatGatA329AY.200.000117
ORF1ab/nsp12666M666IatGatT2424B.1.10.000435
ORF1ab/nsp12666M666IatGatT2222B.1.2400.004742
ORF1ab/nsp12666M666IatGatT1819AY.60.00074
ORF1ab/nsp12666M666IatGatA119AY.60.000041
ORF1ab/nsp12666M666IatGatA1919B.1.1.3060.00833
ORF1ab/nsp12666M666IatGatT1314AY.250.000078
ORF1ab/nsp12666M666IatGatA114AY.250.000006
ORF1ab/nsp12666M666IatGatT1214AY.50.000248
ORF1ab/nsp12666M666IatGatA214AY.50.000041
ORF1ab/nsp12666M666IatGatT812AY.1030.00005
ORF1ab/nsp12666M666IatGatA412AY.1030.000025
ORF1ab/nsp12666M666IatGatT1112B.1.1600.000343
ORF1ab/nsp12666M666IatGatA112B.1.1600.000031
ORF1ab/nsp12666M666IatGatT911AY.1020.000239
ORF1ab/nsp12666M666IatGatC211AY.1020.000053
ORF1ab/nsp12666M666IatGatT1011B0.001278
ORF1ab/nsp12666M666IatGatA111B0.000128
ORF1ab/nsp12666M666IatGatA710B.1.1.5190.000278
ORF1ab/nsp12666M666IatGatT310B.1.1.5190.000119
ORF1ab/nsp12666M666IatGatT1010B.1.4090.007812
ORF1ab/nsp12666M666IatGatT99B.1.1.3050.034749
ORF1ab/nsp12666M666IatGatT89B.1.2580.000532
ORF1ab/nsp12666M666IatGatA19B.1.2580.000067
ORF1ab/nsp12666M666IatGatA88AY.4.20.000174
ORF1ab/nsp12666M666IatGatT67AY.290.000095
ORF1ab/nsp12666M666IatGatA17AY.290.000016
ORF1ab/nsp12666M666IatGatT77B.1.1.280.002179
ORF1ab/nsp12666M666IatGatT56AY.1000.00023
ORF1ab/nsp12666M666IatGatA16AY.1000.000046
ORF1ab/nsp12666M666IatGatT66B.1.1.2160.005343
ORF1ab/nsp12666M666IatGatC46B.1.1.270.022599
ORF1ab/nsp12666M666IatGatT26B.1.1.270.011299
ORF1ab/nsp12666M666IatGatT56B.1.258.170.00052
ORF1ab/nsp12666M666IatGatC16B.1.258.170.000104
ORF1ab/nsp12666M666IatGatT66B.1.3110.001647
ORF1ab/nsp12666M666IatGatT55B.1.4280.005102
ORF1ab/nsp12666M666IatGatA35B.1.6370.000219
ORF1ab/nsp12666M666IatGatT25B.1.6370.000146
ORF1ab/nsp12666M666IatGatT44A.10.001127
ORF1ab/nsp12666M666IatGatT34B.1.3510.000089
ORF1ab/nsp12666M666IatGatA14B.1.3510.00003
ORF1ab/nsp12666M666IatGatA24B.1.360.000292
ORF1ab/nsp12666M666IatGatT24B.1.360.000292
ORF1ab/nsp12666M666IatGatT44B.1.36.170.001976
ORF1ab/nsp12666M666IatGatT44B.1.3960.002823
ORF1ab/nsp12666M666IatGatT44B.1.5950.001044
ORF1ab/nsp12666M666IatGatA13AY.1170.000085
ORF1ab/nsp12666M666IatGatT13AY.1170.000085
ORF1ab/nsp12666M666IatGatC13AY.1170.000085
ORF1ab/nsp12666M666IatGatT33AY.1180.000188
ORF1ab/nsp12666M666IatGatT33AY.340.000291
ORF1ab/nsp12666M666IatGatT33AY.460.000312
ORF1ab/nsp12666M666IatGatA33B.1.1.2040.009119
ORF1ab/nsp12666M666IatGatA23B.1.1.370.000386
ORF1ab/nsp12666M666IatGatT13B.1.1.370.000193
ORF1ab/nsp12666M666IatGatT33B.1.177.440.001557
ORF1ab/nsp12666M666IatGatT33B.1.2350.007557
ORF1ab/nsp12666M666IatGatT33B.1.3620.004622
ORF1ab/nsp12666M666IatGatT23B.1.5960.000174
ORF1ab/nsp12666M666IatGatA13B.1.5960.000087
ORF1ab/nsp12666M666IatGatT33D.20.000225
ORF1ab/nsp12666M666IatGatT23P.10.000032
ORF1ab/nsp12666M666IatGatA13P.10.000016
ORF1ab/nsp12666M666IatGatT22A.23.10.001408
ORF1ab/nsp12666M666IatGatA22AY.1190.000071
ORF1ab/nsp12666M666IatGatT22AY.1200.000074
ORF1ab/nsp12666M666IatGatT12AY.1210.000135
ORF1ab/nsp12666M666IatGatA12AY.1210.000135
ORF1ab/nsp12666M666IatGatT22AY.260.000057
ORF1ab/nsp12666M666IatGatA22AY.3.10.000171
ORF1ab/nsp12666M666IatGatT22AY.390.000049
ORF1ab/nsp12666M666IatGatT22AY.450.000243
ORF1ab/nsp12666M666IatGatA12AY.470.000031
ORF1ab/nsp12666M666IatGatT12AY.470.000031
ORF1ab/nsp12666M666IatGatT22AY.99.10.003106
ORF1ab/nsp12666M666IatGatT12AY.99.20.000092
ORF1ab/nsp12666M666IatGatA12AY.99.20.000092
ORF1ab/nsp12666M666IatGatT22B.1.1.10.000653
ORF1ab/nsp12666M666IatGatT22B.1.1.1150.017857
ORF1ab/nsp12666M666IatGatT22B.1.1.1440.057143
ORF1ab/nsp12666M666IatGatT22B.1.1150.043478
ORF1ab/nsp12666M666IatGatT22B.1.177.870.001456
ORF1ab/nsp12666M666IatGatT22B.1.258.30.00335
ORF1ab/nsp12666M666IatGatT22B.1.351.20.000605
ORF1ab/nsp12666M666IatGatT22B.1.3610.002577
ORF1ab/nsp12666M666IatGatT22B.1.438.10.000215
ORF1ab/nsp12666M666IatGatA22B.1.5380.016129
ORF1ab/nsp12666M666IatGatT22B.1.5820.000981
ORF1ab/nsp12666M666IatGatT22B.1.6090.000959
ORF1ab/nsp12666M666IatGatT22B.1.617.10.000258
ORF1ab/nsp12666M666IatGatA22C.360.001821
ORF1ab/nsp12666M666IatGatT11A0.000387
ORF1ab/nsp12666M666IatGatA11A.2.40.003367
ORF1ab/nsp12666M666IatGatA11AY.1040.001984
ORF1ab/nsp12666M666IatGatA11AY.1050.000643
ORF1ab/nsp12666M666IatGatT11AY.1160.000287
ORF1ab/nsp12666M666IatGatT11AY.120.10.000321
ORF1ab/nsp12666M666IatGatT11AY.130.000161
ORF1ab/nsp12666M666IatGatT11AY.170.008197
ORF1ab/nsp12666M666IatGatA11AY.23.10.000417
ORF1ab/nsp12666M666IatGatT11AY.240.000431
ORF1ab/nsp12666M666IatGatT11AY.270.000065
ORF1ab/nsp12666M666IatGatT11AY.29.10.000221
ORF1ab/nsp12666M666IatGatT11AY.300.000396
ORF1ab/nsp12666M666IatGatT11AY.330.000067
ORF1ab/nsp12666M666IatGatA11AY.360.000148
ORF1ab/nsp12666M666IatGatT11AY.39.10.00004
ORF1ab/nsp12666M666IatGatT11AY.420.00004
ORF1ab/nsp12666M666IatGatT11AY.570.000656
ORF1ab/nsp12666M666IatGatT11AY.640.000595
ORF1ab/nsp12666M666IatGatT11AY.920.000287
ORF1ab/nsp12666M666IatGatT11AY.930.000273
ORF1ab/nsp12666M666IatGatT11AY.98.10.000048
ORF1ab/nsp12666M666IatGatC11B.1.1.1380.006061
ORF1ab/nsp12666M666IatGatT11B.1.1.150.013514
ORF1ab/nsp12666M666IatGatA11B.1.1.1570.000913
ORF1ab/nsp12666M666IatGatT11B.1.1.1610.003534
ORF1ab/nsp12666M666IatGatT11B.1.1.1940.00495
ORF1ab/nsp12666M666IatGatT11B.1.1.2140.000055
ORF1ab/nsp12666M666IatGatT11B.1.1.2220.000204
ORF1ab/nsp12666M666IatGatT11B.1.1.2430.004082
ORF1ab/nsp12666M666IatGatT11B.1.1.3160.000925
ORF1ab/nsp12666M666IatGatT11B.1.1.330.000421
ORF1ab/nsp12666M666IatGatT11B.1.1.3720.000689
ORF1ab/nsp12666M666IatGatT11B.1.1.3750.011905
ORF1ab/nsp12666M666IatGatT11B.1.1.3760.005952
ORF1ab/nsp12666M666IatGatA11B.1.1.3970.002252
ORF1ab/nsp12666M666IatGatT11B.1.1.4320.001266
ORF1ab/nsp12666M666IatGatT11B.1.1.4340.000349
ORF1ab/nsp12666M666IatGatT11B.1.1.4480.002033
ORF1ab/nsp12666M666IatGatT11B.1.1.5230.001563
ORF1ab/nsp12666M666IatGatT11B.1.1.890.006061
ORF1ab/nsp12666M666IatGatT11B.1.110.30.000718
ORF1ab/nsp12666M666IatGatT11B.1.1570.002985
ORF1ab/nsp12666M666IatGatT11B.1.177.600.000218
ORF1ab/nsp12666M666IatGatT11B.1.177.720.00339
ORF1ab/nsp12666M666IatGatT11B.1.177.730.000566
ORF1ab/nsp12666M666IatGatT11B.1.214.20.0006
ORF1ab/nsp12666M666IatGatA11B.1.2210.000071
ORF1ab/nsp12666M666IatGatT11B.1.221.20.004016
ORF1ab/nsp12666M666IatGatT11B.1.2600.003344
ORF1ab/nsp12666M666IatGatT11B.1.3050.002151
ORF1ab/nsp12666M666IatGatA11B.1.3330.010526
ORF1ab/nsp12666M666IatGatT11B.1.36.100.004785
ORF1ab/nsp12666M666IatGatA11B.1.36.160.001425
ORF1ab/nsp12666M666IatGatT11B.1.36.250.002208
ORF1ab/nsp12666M666IatGatA11B.1.36.290.000517
ORF1ab/nsp12666M666IatGatT11B.1.3670.000792
ORF1ab/nsp12666M666IatGatT11B.1.3690.000285
ORF1ab/nsp12666M666IatGatT11B.1.4590.004082
ORF1ab/nsp12666M666IatGatT11B.1.4700.001404
ORF1ab/nsp12666M666IatGatT11B.1.5510.00129
ORF1ab/nsp12666M666IatGatT11B.1.5880.00091
ORF1ab/nsp12666M666IatGatT11B.1.617.30.002985
ORF1ab/nsp12666M666IatGatC11B.1.6210.000089
ORF1ab/nsp12666M666IatGatA11B.1.9.50.005682
ORF1ab/nsp12666M666IatGatT11B.30.000831
ORF1ab/nsp12666M666IatGatT11C.300.001727
ORF1ab/nsp12666M666IatGatA11C.370.000116
ORF1ab/nsp12666M666IatGatT11C.390.018868
ORF1ab/nsp12666M666IatGatT11P.1.120.000484
ORF1ab/nsp12666M666IatGatC11P.1.140.000048
ORF1ab/nsp12666M666IatGatT11P.1.160.000374
ORF1ab/nsp12666M666IatGatT11P.20.000187

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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