CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = M463I

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12463M463IM4855InonsynatGatT12651123440.97573314827-14829
ORF1ab/nsp12463M463IM4855InonsynatGatA126511540.01217314827-14829
ORF1ab/nsp12463M463IM4855InonsynatGatC126511530.012093914827-14829

Details of the mutation M463I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12463M463IatGatT1234412651All0.002361
ORF1ab/nsp12463M463IatGatA15412651All0.000029
ORF1ab/nsp12463M463IatGatC15312651All0.000029
ORF1ab/nsp12463M463IatGatT81298170AY.40.012652
ORF1ab/nsp12463M463IatGatA318170AY.40.000048
ORF1ab/nsp12463M463IatGatC108170AY.40.000016
ORF1ab/nsp12463M463IatGatT432450B.1.617.20.001627
ORF1ab/nsp12463M463IatGatC12450B.1.617.20.000045
ORF1ab/nsp12463M463IatGatA6450B.1.617.20.000023
ORF1ab/nsp12463M463IatGatT378420B.1.1.70.000338
ORF1ab/nsp12463M463IatGatA38420B.1.1.70.000034
ORF1ab/nsp12463M463IatGatC4420B.1.1.70.000004
ORF1ab/nsp12463M463IatGatT414415AY.1030.002571
ORF1ab/nsp12463M463IatGatA1415AY.1030.000006
ORF1ab/nsp12463M463IatGatT394411B.1.20.003469
ORF1ab/nsp12463M463IatGatC16411B.1.20.000141
ORF1ab/nsp12463M463IatGatA1411B.1.20.000009
ORF1ab/nsp12463M463IatGatT231241AY.430.001023
ORF1ab/nsp12463M463IatGatA10241AY.430.000044
ORF1ab/nsp12463M463IatGatT221226P.10.003482
ORF1ab/nsp12463M463IatGatA4226P.10.000063
ORF1ab/nsp12463M463IatGatC1226P.10.000016
ORF1ab/nsp12463M463IatGatT169173B.10.001548
ORF1ab/nsp12463M463IatGatC3173B.10.000027
ORF1ab/nsp12463M463IatGatA1173B.10.000009
ORF1ab/nsp12463M463IatGatT146155AY.440.000889
ORF1ab/nsp12463M463IatGatA9155AY.440.000055
ORF1ab/nsp12463M463IatGatT143152AY.250.00086
ORF1ab/nsp12463M463IatGatA9152AY.250.000054
ORF1ab/nsp12463M463IatGatT150150B.1.6060.903614
ORF1ab/nsp12463M463IatGatC6697AY.46.60.004766
ORF1ab/nsp12463M463IatGatT3197AY.46.60.002238
ORF1ab/nsp12463M463IatGatT9293AY.290.001451
ORF1ab/nsp12463M463IatGatC193AY.290.000016
ORF1ab/nsp12463M463IatGatT7377AY.50.001507
ORF1ab/nsp12463M463IatGatA477AY.50.000083
ORF1ab/nsp12463M463IatGatT5858B.1.10.001052
ORF1ab/nsp12463M463IatGatT5555AY.740.006361
ORF1ab/nsp12463M463IatGatT5354AY.420.002132
ORF1ab/nsp12463M463IatGatA154AY.420.00004
ORF1ab/nsp12463M463IatGatT5050P.1.70.015964
ORF1ab/nsp12463M463IatGatT4044AY.390.000988
ORF1ab/nsp12463M463IatGatC244AY.390.000049
ORF1ab/nsp12463M463IatGatA244AY.390.000049
ORF1ab/nsp12463M463IatGatT4243AY.1020.001114
ORF1ab/nsp12463M463IatGatC143AY.1020.000027
ORF1ab/nsp12463M463IatGatT3939AY.90.002636
ORF1ab/nsp12463M463IatGatT3838AY.980.003002
ORF1ab/nsp12463M463IatGatT3636AY.1090.026627
ORF1ab/nsp12463M463IatGatT3434B.1.4290.0008
ORF1ab/nsp12463M463IatGatT3131AY.98.10.001501
ORF1ab/nsp12463M463IatGatT3131B.1.5960.002701
ORF1ab/nsp12463M463IatGatT2829B.1.1770.000369
ORF1ab/nsp12463M463IatGatA129B.1.1770.000013
ORF1ab/nsp12463M463IatGatT2626AY.200.00101
ORF1ab/nsp12463M463IatGatT2026AY.30.000199
ORF1ab/nsp12463M463IatGatC626AY.30.00006
ORF1ab/nsp12463M463IatGatT2323AY.1200.000855
ORF1ab/nsp12463M463IatGatT2323B.1.5920.92
ORF1ab/nsp12463M463IatGatT2222B.1.1600.000686
ORF1ab/nsp12463M463IatGatT2121B.1.36.380.034483
ORF1ab/nsp12463M463IatGatC1920B.1.3690.005419
ORF1ab/nsp12463M463IatGatT120B.1.3690.000285
ORF1ab/nsp12463M463IatGatT1919B.1.5950.004958
ORF1ab/nsp12463M463IatGatT1717B.1.3510.000505
ORF1ab/nsp12463M463IatGatT1616AY.4.50.00172
ORF1ab/nsp12463M463IatGatT1515AY.1170.001268
ORF1ab/nsp12463M463IatGatT1515AY.330.001002
ORF1ab/nsp12463M463IatGatT914AY.470.00028
ORF1ab/nsp12463M463IatGatC414AY.470.000124
ORF1ab/nsp12463M463IatGatA114AY.470.000031
ORF1ab/nsp12463M463IatGatT1414AY.99.20.00129
ORF1ab/nsp12463M463IatGatT1014B.1.6210.000885
ORF1ab/nsp12463M463IatGatA414B.1.6210.000354
ORF1ab/nsp12463M463IatGatT1313AY.1060.004354
ORF1ab/nsp12463M463IatGatT1213AY.1190.000424
ORF1ab/nsp12463M463IatGatA113AY.1190.000035
ORF1ab/nsp12463M463IatGatT1313AY.460.001353
ORF1ab/nsp12463M463IatGatT1313B.1.177.160.008638
ORF1ab/nsp12463M463IatGatT1113B.1.5260.000259
ORF1ab/nsp12463M463IatGatA213B.1.5260.000047
ORF1ab/nsp12463M463IatGatT1213P.1.140.000574
ORF1ab/nsp12463M463IatGatC113P.1.140.000048
ORF1ab/nsp12463M463IatGatT1212AY.410.003527
ORF1ab/nsp12463M463IatGatT1111AY.610.001153
ORF1ab/nsp12463M463IatGatT1111B.1.1.700.003752
ORF1ab/nsp12463M463IatGatT1010AY.160.003797
ORF1ab/nsp12463M463IatGatT1010AY.46.40.001645
ORF1ab/nsp12463M463IatGatT910AY.750.000504
ORF1ab/nsp12463M463IatGatC110AY.750.000056
ORF1ab/nsp12463M463IatGatT1010B.1.1.3110.003582
ORF1ab/nsp12463M463IatGatT89AY.260.000226
ORF1ab/nsp12463M463IatGatA19AY.260.000028
ORF1ab/nsp12463M463IatGatT99AY.4.20.000195
ORF1ab/nsp12463M463IatGatT99B.1.1.3180.002716
ORF1ab/nsp12463M463IatGatT99B.1.2210.000639
ORF1ab/nsp12463M463IatGatT88AY.60.000329
ORF1ab/nsp12463M463IatGatT68B0.000767
ORF1ab/nsp12463M463IatGatA28B0.000256
ORF1ab/nsp12463M463IatGatT88B.1.1.1700.009975
ORF1ab/nsp12463M463IatGatA48B.1.1.5190.000159
ORF1ab/nsp12463M463IatGatT38B.1.1.5190.000119
ORF1ab/nsp12463M463IatGatC18B.1.1.5190.00004
ORF1ab/nsp12463M463IatGatT78B.1.360.001021
ORF1ab/nsp12463M463IatGatA18B.1.360.000146
ORF1ab/nsp12463M463IatGatT67AY.1130.000854
ORF1ab/nsp12463M463IatGatA17AY.1130.000142
ORF1ab/nsp12463M463IatGatT77AY.1210.000947
ORF1ab/nsp12463M463IatGatT77AY.650.003731
ORF1ab/nsp12463M463IatGatT77AY.940.003099
ORF1ab/nsp12463M463IatGatT77B.1.1.250.00398
ORF1ab/nsp12463M463IatGatT77B.1.2400.001509
ORF1ab/nsp12463M463IatGatT57B.1.5250.000566
ORF1ab/nsp12463M463IatGatA27B.1.5250.000226
ORF1ab/nsp12463M463IatGatT77Q.30.001015
ORF1ab/nsp12463M463IatGatT66AY.4.40.002455
ORF1ab/nsp12463M463IatGatT66B.1.6370.000438
ORF1ab/nsp12463M463IatGatT55AY.1100.000563
ORF1ab/nsp12463M463IatGatT55AY.1180.000313
ORF1ab/nsp12463M463IatGatT55AY.270.000324
ORF1ab/nsp12463M463IatGatT55B.1.2340.00066
ORF1ab/nsp12463M463IatGatT55B.1.2430.000348
ORF1ab/nsp12463M463IatGatT55B.1.5610.001985
ORF1ab/nsp12463M463IatGatT55B.1.617.10.000645
ORF1ab/nsp12463M463IatGatT55C.350.00387
ORF1ab/nsp12463M463IatGatT55P.1.150.001162
ORF1ab/nsp12463M463IatGatT44AY.120.001264
ORF1ab/nsp12463M463IatGatT44AY.140.000352
ORF1ab/nsp12463M463IatGatT44AY.350.000932
ORF1ab/nsp12463M463IatGatT34AY.540.000286
ORF1ab/nsp12463M463IatGatC14AY.540.000095
ORF1ab/nsp12463M463IatGatT44AY.75.10.000721
ORF1ab/nsp12463M463IatGatT44AY.9.10.000335
ORF1ab/nsp12463M463IatGatT34AY.920.000862
ORF1ab/nsp12463M463IatGatC14AY.920.000287
ORF1ab/nsp12463M463IatGatT44B.1.1.630.001543
ORF1ab/nsp12463M463IatGatT44B.1.177.730.002265
ORF1ab/nsp12463M463IatGatA24B.1.2580.000133
ORF1ab/nsp12463M463IatGatT24B.1.2580.000133
ORF1ab/nsp12463M463IatGatT44P.20.000747
ORF1ab/nsp12463M463IatGatT33A0.001161
ORF1ab/nsp12463M463IatGatT33AY.1000.000138
ORF1ab/nsp12463M463IatGatT33AY.1070.001398
ORF1ab/nsp12463M463IatGatT33AY.1160.00086
ORF1ab/nsp12463M463IatGatT23AY.320.001065
ORF1ab/nsp12463M463IatGatA13AY.320.000532
ORF1ab/nsp12463M463IatGatT33AY.39.10.000119
ORF1ab/nsp12463M463IatGatT33AY.450.000365
ORF1ab/nsp12463M463IatGatT33AY.480.001395
ORF1ab/nsp12463M463IatGatT33AY.530.000863
ORF1ab/nsp12463M463IatGatT33AY.550.002752
ORF1ab/nsp12463M463IatGatT33AY.7.10.000338
ORF1ab/nsp12463M463IatGatT33AY.840.001312
ORF1ab/nsp12463M463IatGatT33AY.850.001282
ORF1ab/nsp12463M463IatGatT23AY.9.20.000073
ORF1ab/nsp12463M463IatGatC13AY.9.20.000037
ORF1ab/nsp12463M463IatGatT33B.1.1.2140.000166
ORF1ab/nsp12463M463IatGatT23B.1.1.280.000622
ORF1ab/nsp12463M463IatGatA13B.1.1.280.000311
ORF1ab/nsp12463M463IatGatT33B.1.1.3050.011583
ORF1ab/nsp12463M463IatGatT33B.1.1.390.001529
ORF1ab/nsp12463M463IatGatT33B.1.177.40.000633
ORF1ab/nsp12463M463IatGatT33B.1.4270.000151
ORF1ab/nsp12463M463IatGatT33B.1.5640.001278
ORF1ab/nsp12463M463IatGatA33B.1.5870.005693
ORF1ab/nsp12463M463IatGatT33C.360.002732
ORF1ab/nsp12463M463IatGatT33C.370.000348
ORF1ab/nsp12463M463IatGatT23D.20.00015
ORF1ab/nsp12463M463IatGatA13D.20.000075
ORF1ab/nsp12463M463IatGatT23P.1.120.000968
ORF1ab/nsp12463M463IatGatA13P.1.120.000484
ORF1ab/nsp12463M463IatGatT22A.2.50.000998
ORF1ab/nsp12463M463IatGatT22A.300.285714
ORF1ab/nsp12463M463IatGatT22AY.29.10.000441
ORF1ab/nsp12463M463IatGatT22AY.3.10.000171
ORF1ab/nsp12463M463IatGatT12AY.300.000396
ORF1ab/nsp12463M463IatGatA12AY.300.000396
ORF1ab/nsp12463M463IatGatT22AY.46.10.002053
ORF1ab/nsp12463M463IatGatT22AY.5.40.000553
ORF1ab/nsp12463M463IatGatT22AY.590.001059
ORF1ab/nsp12463M463IatGatT22AY.680.000547
ORF1ab/nsp12463M463IatGatT22AY.700.000417
ORF1ab/nsp12463M463IatGatT22AY.970.003401
ORF1ab/nsp12463M463IatGatT22AZ.20.001642
ORF1ab/nsp12463M463IatGatT22B.1.1.10.000653
ORF1ab/nsp12463M463IatGatT22B.1.1.2220.000408
ORF1ab/nsp12463M463IatGatT22B.1.1.3060.000877
ORF1ab/nsp12463M463IatGatT22B.1.1.610.017544
ORF1ab/nsp12463M463IatGatT22B.1.1110.00235
ORF1ab/nsp12463M463IatGatT22B.1.1470.001512
ORF1ab/nsp12463M463IatGatT22B.1.177.340.105263
ORF1ab/nsp12463M463IatGatT22B.1.2100.004264
ORF1ab/nsp12463M463IatGatT22B.1.2390.002442
ORF1ab/nsp12463M463IatGatT22B.1.2410.001623
ORF1ab/nsp12463M463IatGatA22B.1.5820.000981
ORF1ab/nsp12463M463IatGatT22B.1.619.10.001283
ORF1ab/nsp12463M463IatGatT22B.1.6230.001073
ORF1ab/nsp12463M463IatGatT22B.60.00182
ORF1ab/nsp12463M463IatGatT110.055556
ORF1ab/nsp12463M463IatGatT11A.270.001656
ORF1ab/nsp12463M463IatGatC11AY.100.00053
ORF1ab/nsp12463M463IatGatT11AY.1110.000183
ORF1ab/nsp12463M463IatGatT11AY.120.10.000321
ORF1ab/nsp12463M463IatGatT11AY.16.10.00047
ORF1ab/nsp12463M463IatGatT11AY.230.00007
ORF1ab/nsp12463M463IatGatT11AY.23.10.000417
ORF1ab/nsp12463M463IatGatT11AY.240.000431
ORF1ab/nsp12463M463IatGatT11AY.340.000097
ORF1ab/nsp12463M463IatGatT11AY.34.10.00051
ORF1ab/nsp12463M463IatGatT11AY.360.000148
ORF1ab/nsp12463M463IatGatT11AY.380.000499
ORF1ab/nsp12463M463IatGatT11AY.4.30.000842
ORF1ab/nsp12463M463IatGatT11AY.400.000964
ORF1ab/nsp12463M463IatGatT11AY.46.20.000635
ORF1ab/nsp12463M463IatGatT11AY.770.001127
ORF1ab/nsp12463M463IatGatT11AY.880.000884
ORF1ab/nsp12463M463IatGatT11AY.91.10.004065
ORF1ab/nsp12463M463IatGatT11AY.930.000273
ORF1ab/nsp12463M463IatGatT11AY.950.000761
ORF1ab/nsp12463M463IatGatA11AY.990.001049
ORF1ab/nsp12463M463IatGatT11B.1.1.1900.05
ORF1ab/nsp12463M463IatGatT11B.1.1.2410.00207
ORF1ab/nsp12463M463IatGatT11B.1.1.2630.001558
ORF1ab/nsp12463M463IatGatT11B.1.1.3170.000412
ORF1ab/nsp12463M463IatGatT11B.1.1.330.000421
ORF1ab/nsp12463M463IatGatT11B.1.1.3690.000446
ORF1ab/nsp12463M463IatGatT11B.1.1.3720.000689
ORF1ab/nsp12463M463IatGatT11B.1.1.4640.001473
ORF1ab/nsp12463M463IatGatT11B.1.1.4810.071429
ORF1ab/nsp12463M463IatGatT11B.1.1.500.000679
ORF1ab/nsp12463M463IatGatT11B.1.177.210.000076
ORF1ab/nsp12463M463IatGatT11B.1.177.310.011494
ORF1ab/nsp12463M463IatGatT11B.1.177.320.00135
ORF1ab/nsp12463M463IatGatT11B.1.177.570.000281
ORF1ab/nsp12463M463IatGatT11B.1.177.600.000218
ORF1ab/nsp12463M463IatGatT11B.1.177.80.000752
ORF1ab/nsp12463M463IatGatT11B.1.1790.003759
ORF1ab/nsp12463M463IatGatT11B.1.2060.000816
ORF1ab/nsp12463M463IatGatT11B.1.2180.005155
ORF1ab/nsp12463M463IatGatT11B.1.2250.015385
ORF1ab/nsp12463M463IatGatT11B.1.2330.014085
ORF1ab/nsp12463M463IatGatT11B.1.258.170.000104
ORF1ab/nsp12463M463IatGatT11B.1.3110.000275
ORF1ab/nsp12463M463IatGatA11B.1.3240.001605
ORF1ab/nsp12463M463IatGatT11B.1.36.180.00042
ORF1ab/nsp12463M463IatGatT11B.1.36.70.004
ORF1ab/nsp12463M463IatGatT11B.1.3710.001122
ORF1ab/nsp12463M463IatGatT11B.1.3820.008929
ORF1ab/nsp12463M463IatGatT11B.1.3950.007042
ORF1ab/nsp12463M463IatGatT11B.1.3970.004854
ORF1ab/nsp12463M463IatGatT11B.1.4060.006061
ORF1ab/nsp12463M463IatGatT11B.1.4280.00102
ORF1ab/nsp12463M463IatGatT11B.1.4530.003236
ORF1ab/nsp12463M463IatGatT11B.1.466.20.000391
ORF1ab/nsp12463M463IatGatT11B.1.4700.001404
ORF1ab/nsp12463M463IatGatT11B.1.4950.009091
ORF1ab/nsp12463M463IatGatT11B.1.4990.00105
ORF1ab/nsp12463M463IatGatT11B.1.5170.000427
ORF1ab/nsp12463M463IatGatA11B.1.5650.00081
ORF1ab/nsp12463M463IatGatT11B.1.5750.000303
ORF1ab/nsp12463M463IatGatT11B.1.575.10.002439
ORF1ab/nsp12463M463IatGatT11B.1.5760.000907
ORF1ab/nsp12463M463IatGatA11B.1.6050.005952
ORF1ab/nsp12463M463IatGatT11B.1.6260.005714
ORF1ab/nsp12463M463IatGatT11B.1.6270.00202
ORF1ab/nsp12463M463IatGatT11B.1.6280.000352
ORF1ab/nsp12463M463IatGatC11B.1.90.006173
ORF1ab/nsp12463M463IatGatT11C.10.002392
ORF1ab/nsp12463M463IatGatT11C.320.023256
ORF1ab/nsp12463M463IatGatT11C.36.30.000567
ORF1ab/nsp12463M463IatGatT11D.50.004975
ORF1ab/nsp12463M463IatGatA11N.50.001767
ORF1ab/nsp12463M463IatGatT11P.1.100.000269
ORF1ab/nsp12463M463IatGatT11P.1.170.000162
ORF1ab/nsp12463M463IatGatT11P.1.20.001156
ORF1ab/nsp12463M463IatGatT11Q.10.000126
ORF1ab/nsp12463M463IatGatT11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.