CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = L308L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12308L308LL4700LsynCtgTtg364130430.83575914362-14364
ORF1ab/nsp12308L308LL4700LsynctGctT36413180.087338614362-14364
ORF1ab/nsp12308L308LL4700LsynctGctA36412780.076352614362-14364
ORF1ab/nsp12308L308LL4700LsynctGctC364120.000549314362-14364

Details of the mutation L308L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12308L308LCtgTtg30433641All0.000582
ORF1ab/nsp12308L308LctGctT3183641All0.000061
ORF1ab/nsp12308L308LctGctA2783641All0.000053
ORF1ab/nsp12308L308LctGctC23641All0
ORF1ab/nsp12308L308LCtgTtg26592659AY.680.727895
ORF1ab/nsp12308L308LctGctT199405AY.40.00031
ORF1ab/nsp12308L308LctGctA172405AY.40.000268
ORF1ab/nsp12308L308LCtgTtg32405AY.40.00005
ORF1ab/nsp12308L308LctGctC2405AY.40.000003
ORF1ab/nsp12308L308LCtgTtg4477B.1.1.70.000039
ORF1ab/nsp12308L308LctGctA2577B.1.1.70.000022
ORF1ab/nsp12308L308LctGctT877B.1.1.70.000007
ORF1ab/nsp12308L308LctGctT4169B.1.617.20.000154
ORF1ab/nsp12308L308LctGctA1769B.1.617.20.000064
ORF1ab/nsp12308L308LCtgTtg1169B.1.617.20.000041
ORF1ab/nsp12308L308LCtgTtg4954B.10.000449
ORF1ab/nsp12308L308LctGctT554B.10.000046
ORF1ab/nsp12308L308LCtgTtg1835AY.440.00011
ORF1ab/nsp12308L308LctGctT1035AY.440.000061
ORF1ab/nsp12308L308LctGctA735AY.440.000043
ORF1ab/nsp12308L308LctGctT2532AY.250.00015
ORF1ab/nsp12308L308LCtgTtg632AY.250.000036
ORF1ab/nsp12308L308LctGctA132AY.250.000006
ORF1ab/nsp12308L308LctGctA1722AY.430.000075
ORF1ab/nsp12308L308LCtgTtg322AY.430.000013
ORF1ab/nsp12308L308LctGctT222AY.430.000009
ORF1ab/nsp12308L308LCtgTtg1119B.1.10.0002
ORF1ab/nsp12308L308LctGctT819B.1.10.000145
ORF1ab/nsp12308L308LCtgTtg1818B.1.1.280.005602
ORF1ab/nsp12308L308LCtgTtg1414AY.9.10.001172
ORF1ab/nsp12308L308LCtgTtg914B.1.4290.000212
ORF1ab/nsp12308L308LctGctA514B.1.4290.000118
ORF1ab/nsp12308L308LCtgTtg1112AY.1030.000068
ORF1ab/nsp12308L308LctGctA112AY.1030.000006
ORF1ab/nsp12308L308LCtgTtg1012B.1.1770.000132
ORF1ab/nsp12308L308LctGctA212B.1.1770.000026
ORF1ab/nsp12308L308LCtgTtg99B.1.2430.000626
ORF1ab/nsp12308L308LCtgTtg88B.1.4950.072727
ORF1ab/nsp12308L308LCtgTtg68P.10.000095
ORF1ab/nsp12308L308LctGctT28P.10.000032
ORF1ab/nsp12308L308LCtgTtg57AY.390.000124
ORF1ab/nsp12308L308LctGctA27AY.390.000049
ORF1ab/nsp12308L308LCtgTtg77AY.9.20.000257
ORF1ab/nsp12308L308LCtgTtg77B.1.177.160.004651
ORF1ab/nsp12308L308LCtgTtg55C.36.30.002836
ORF1ab/nsp12308L308LCtgTtg45D.20.0003
ORF1ab/nsp12308L308LctGctT15D.20.000075
ORF1ab/nsp12308L308LCtgTtg24AY.1020.000053
ORF1ab/nsp12308L308LctGctT24AY.1020.000053
ORF1ab/nsp12308L308LCtgTtg34AY.1200.000112
ORF1ab/nsp12308L308LctGctT14AY.1200.000037
ORF1ab/nsp12308L308LctGctA44AY.99.20.000369
ORF1ab/nsp12308L308LCtgTtg44B.1.1.3070.010127
ORF1ab/nsp12308L308LCtgTtg24B.1.1.4340.000697
ORF1ab/nsp12308L308LctGctT24B.1.1.4340.000697
ORF1ab/nsp12308L308LCtgTtg44B.1.3510.000119
ORF1ab/nsp12308L308LCtgTtg44B.1.5960.000349
ORF1ab/nsp12308L308LCtgTtg23AY.1180.000125
ORF1ab/nsp12308L308LctGctT13AY.1180.000063
ORF1ab/nsp12308L308LCtgTtg23AY.200.000078
ORF1ab/nsp12308L308LctGctA13AY.200.000039
ORF1ab/nsp12308L308LctGctA33AY.30.00003
ORF1ab/nsp12308L308LctGctT23AY.470.000062
ORF1ab/nsp12308L308LCtgTtg13AY.470.000031
ORF1ab/nsp12308L308LCtgTtg23AY.50.000041
ORF1ab/nsp12308L308LctGctA13AY.50.000021
ORF1ab/nsp12308L308LctGctA23AY.60.000082
ORF1ab/nsp12308L308LctGctT13AY.60.000041
ORF1ab/nsp12308L308LCtgTtg33AY.610.000314
ORF1ab/nsp12308L308LCtgTtg33AY.850.001282
ORF1ab/nsp12308L308LctGctA33AY.90.000203
ORF1ab/nsp12308L308LCtgTtg33B.1.20.000026
ORF1ab/nsp12308L308LCtgTtg33B.1.3490.002144
ORF1ab/nsp12308L308LCtgTtg23B.1.4270.000101
ORF1ab/nsp12308L308LctGctA13B.1.4270.00005
ORF1ab/nsp12308L308LCtgTtg33P.20.00056
ORF1ab/nsp12308L308LctGctA12AY.1000.000046
ORF1ab/nsp12308L308LctGctT12AY.1000.000046
ORF1ab/nsp12308L308LCtgTtg22AY.1130.000285
ORF1ab/nsp12308L308LctGctA12AY.230.00007
ORF1ab/nsp12308L308LCtgTtg12AY.230.00007
ORF1ab/nsp12308L308LCtgTtg22AY.240.000862
ORF1ab/nsp12308L308LctGctT12AY.330.000067
ORF1ab/nsp12308L308LCtgTtg12AY.330.000067
ORF1ab/nsp12308L308LCtgTtg12AY.450.000122
ORF1ab/nsp12308L308LctGctA12AY.450.000122
ORF1ab/nsp12308L308LCtgTtg22AY.750.000112
ORF1ab/nsp12308L308LCtgTtg22B.1.1.3160.00185
ORF1ab/nsp12308L308LctGctT22B.1.1.3180.000604
ORF1ab/nsp12308L308LCtgTtg22B.1.1.5190.000079
ORF1ab/nsp12308L308LctGctA12B.1.177.40.000211
ORF1ab/nsp12308L308LCtgTtg12B.1.177.40.000211
ORF1ab/nsp12308L308LCtgTtg22B.1.4000.000858
ORF1ab/nsp12308L308LCtgTtg22P.1.140.000096
ORF1ab/nsp12308L308LctGctA11A.2.50.000499
ORF1ab/nsp12308L308LctGctA11A.23.10.000704
ORF1ab/nsp12308L308LCtgTtg11AL.10.012987
ORF1ab/nsp12308L308LCtgTtg11AY.1100.000113
ORF1ab/nsp12308L308LCtgTtg11AY.1190.000035
ORF1ab/nsp12308L308LctGctT11AY.16.10.00047
ORF1ab/nsp12308L308LctGctA11AY.20.000356
ORF1ab/nsp12308L308LCtgTtg11AY.260.000028
ORF1ab/nsp12308L308LCtgTtg11AY.270.000065
ORF1ab/nsp12308L308LCtgTtg11AY.290.000016
ORF1ab/nsp12308L308LctGctT11AY.300.000396
ORF1ab/nsp12308L308LCtgTtg11AY.350.000233
ORF1ab/nsp12308L308LctGctA11AY.360.000148
ORF1ab/nsp12308L308LCtgTtg11AY.420.00004
ORF1ab/nsp12308L308LCtgTtg11AY.46.40.000165
ORF1ab/nsp12308L308LCtgTtg11AY.5.30.000337
ORF1ab/nsp12308L308LCtgTtg11AY.530.000288
ORF1ab/nsp12308L308LCtgTtg11AY.630.000387
ORF1ab/nsp12308L308LCtgTtg11AY.690.000187
ORF1ab/nsp12308L308LCtgTtg11AY.700.000209
ORF1ab/nsp12308L308LCtgTtg11AY.75.10.00018
ORF1ab/nsp12308L308LctGctA11AY.920.000287
ORF1ab/nsp12308L308LCtgTtg11B0.000128
ORF1ab/nsp12308L308LCtgTtg11B.1.1.1890.001513
ORF1ab/nsp12308L308LCtgTtg11B.1.1.2550.00303
ORF1ab/nsp12308L308LCtgTtg11B.1.1.2940.001266
ORF1ab/nsp12308L308LCtgTtg11B.1.1.3030.002762
ORF1ab/nsp12308L308LCtgTtg11B.1.1.370.000193
ORF1ab/nsp12308L308LctGctT11B.1.1.4090.002833
ORF1ab/nsp12308L308LCtgTtg11B.1.1.4290.004608
ORF1ab/nsp12308L308LCtgTtg11B.1.1.4500.034483
ORF1ab/nsp12308L308LctGctT11B.1.1600.000031
ORF1ab/nsp12308L308LCtgTtg11B.1.177.570.000281
ORF1ab/nsp12308L308LCtgTtg11B.1.177.600.000218
ORF1ab/nsp12308L308LCtgTtg11B.1.177.620.001192
ORF1ab/nsp12308L308LCtgTtg11B.1.177.770.000726
ORF1ab/nsp12308L308LctGctA11B.1.2400.000216
ORF1ab/nsp12308L308LCtgTtg11B.1.2800.007143
ORF1ab/nsp12308L308LCtgTtg11B.1.36.360.000602
ORF1ab/nsp12308L308LCtgTtg11B.1.3890.001002
ORF1ab/nsp12308L308LctGctA11B.1.3900.010638
ORF1ab/nsp12308L308LctGctA11B.1.3960.000706
ORF1ab/nsp12308L308LCtgTtg11B.1.4110.003704
ORF1ab/nsp12308L308LctGctA11B.1.5750.000303
ORF1ab/nsp12308L308LCtgTtg11B.1.5900.004545
ORF1ab/nsp12308L308LCtgTtg11B.1.5950.000261
ORF1ab/nsp12308L308LCtgTtg11B.1.6120.002653
ORF1ab/nsp12308L308LCtgTtg11B.1.6210.000089
ORF1ab/nsp12308L308LctGctA11B.1.6370.000073
ORF1ab/nsp12308L308LCtgTtg11Q.10.000126

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.