CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = H381L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12381H381LH4773LnonsyncAccTc36180.514581-14583
ORF1ab/nsp12381H381LH4773LnonsyncACcTT36100.27777814581-14583
ORF1ab/nsp12381H381LH4773LnonsyncACcTG3620.055555614581-14583
ORF1ab/nsp12381H381LH4773LnonsynCACTTG3620.055555614581-14583
ORF1ab/nsp12381H381LH4773LnonsyncACcTA3620.055555614581-14583
ORF1ab/nsp12381H381LH4773LnonsynCACTTA3620.055555614581-14583

Details of the mutation H381L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12381H381LcAccTc1836All0.000003
ORF1ab/nsp12381H381LcACcTT1036All0.000002
ORF1ab/nsp12381H381LcACcTG236All0
ORF1ab/nsp12381H381LCACTTG236All0
ORF1ab/nsp12381H381LcACcTA236All0
ORF1ab/nsp12381H381LCACTTA236All0
ORF1ab/nsp12381H381LcAccTc817B.10.000073
ORF1ab/nsp12381H381LcACcTT317B.10.000027
ORF1ab/nsp12381H381LcACcTG217B.10.000018
ORF1ab/nsp12381H381LCACTTG217B.10.000018
ORF1ab/nsp12381H381LcACcTA117B.10.000009
ORF1ab/nsp12381H381LCACTTA117B.10.000009
ORF1ab/nsp12381H381LcAccTc59B.1.1.70.000004
ORF1ab/nsp12381H381LcACcTT49B.1.1.70.000004
ORF1ab/nsp12381H381LCACTTA14B.1.5250.000113
ORF1ab/nsp12381H381LcACcTA14B.1.5250.000113
ORF1ab/nsp12381H381LcACcTT14B.1.5250.000113
ORF1ab/nsp12381H381LcAccTc14B.1.5250.000113
ORF1ab/nsp12381H381LcACcTT12B.1.20.000009
ORF1ab/nsp12381H381LcAccTc12B.1.20.000009
ORF1ab/nsp12381H381LcAccTc12B.1.5760.000907
ORF1ab/nsp12381H381LcACcTT12B.1.5760.000907
ORF1ab/nsp12381H381LcAccTc11B.1.2210.000071
ORF1ab/nsp12381H381LcAccTc11B.1.2580.000067

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.