CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = H381H

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12381H381HH4773HsyncaCcaT18131813114581-14583

Details of the mutation H381H within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12381H381HcaCcaT18131813All0.000347
ORF1ab/nsp12381H381HcaCcaT363363B.1.1.70.000325
ORF1ab/nsp12381H381HcaCcaT289289B.1.1600.009013
ORF1ab/nsp12381H381HcaCcaT114114AY.1000.005245
ORF1ab/nsp12381H381HcaCcaT106106B.1.617.20.000399
ORF1ab/nsp12381H381HcaCcaT7777AY.40.00012
ORF1ab/nsp12381H381HcaCcaT5757AY.1030.000354
ORF1ab/nsp12381H381HcaCcaT5656AY.440.000341
ORF1ab/nsp12381H381HcaCcaT4747B.1.258.240.505376
ORF1ab/nsp12381H381HcaCcaT3838AY.1200.001413
ORF1ab/nsp12381H381HcaCcaT3838B.1.5260.000893
ORF1ab/nsp12381H381HcaCcaT3737B.1.2580.002462
ORF1ab/nsp12381H381HcaCcaT3535P.1.140.001673
ORF1ab/nsp12381H381HcaCcaT3030AY.430.000133
ORF1ab/nsp12381H381HcaCcaT2626AY.250.000156
ORF1ab/nsp12381H381HcaCcaT2525AY.470.000778
ORF1ab/nsp12381H381HcaCcaT2121P.60.066038
ORF1ab/nsp12381H381HcaCcaT2020B.10.000183
ORF1ab/nsp12381H381HcaCcaT1818AY.30.000179
ORF1ab/nsp12381H381HcaCcaT1818B.1.3610.023196
ORF1ab/nsp12381H381HcaCcaT1717B.1.10.000308
ORF1ab/nsp12381H381HcaCcaT1616AY.290.000252
ORF1ab/nsp12381H381HcaCcaT1515AY.4.20.000325
ORF1ab/nsp12381H381HcaCcaT1515B.1.1770.000198
ORF1ab/nsp12381H381HcaCcaT1414B.1.6370.001023
ORF1ab/nsp12381H381HcaCcaT1212AY.1020.000318
ORF1ab/nsp12381H381HcaCcaT1212AY.1190.000424
ORF1ab/nsp12381H381HcaCcaT1212P.1.70.003831
ORF1ab/nsp12381H381HcaCcaT1212R.10.00108
ORF1ab/nsp12381H381HcaCcaT1010AY.390.000247
ORF1ab/nsp12381H381HcaCcaT1010B.1.3510.000297
ORF1ab/nsp12381H381HcaCcaT99B.1.2370.044776
ORF1ab/nsp12381H381HcaCcaT88AY.116.10.002491
ORF1ab/nsp12381H381HcaCcaT88B.1.1.5190.000318
ORF1ab/nsp12381H381HcaCcaT88B.1.466.20.00313
ORF1ab/nsp12381H381HcaCcaT77AY.590.003708
ORF1ab/nsp12381H381HcaCcaT66B.1.1.2140.000333
ORF1ab/nsp12381H381HcaCcaT66B.1.20.000053
ORF1ab/nsp12381H381HcaCcaT66B.1.36.290.003104
ORF1ab/nsp12381H381HcaCcaT55AY.360.000741
ORF1ab/nsp12381H381HcaCcaT55AY.420.000201
ORF1ab/nsp12381H381HcaCcaT55B.1.4240.040323
ORF1ab/nsp12381H381HcaCcaT55B.1.6210.000443
ORF1ab/nsp12381H381HcaCcaT55C.370.00058
ORF1ab/nsp12381H381HcaCcaT44AY.200.000155
ORF1ab/nsp12381H381HcaCcaT44AY.230.000279
ORF1ab/nsp12381H381HcaCcaT44AY.3.10.000341
ORF1ab/nsp12381H381HcaCcaT44AY.50.000083
ORF1ab/nsp12381H381HcaCcaT44AY.650.002132
ORF1ab/nsp12381H381HcaCcaT44B.1.1.2160.003562
ORF1ab/nsp12381H381HcaCcaT44B.1.1.830.01084
ORF1ab/nsp12381H381HcaCcaT44B.1.4560.013072
ORF1ab/nsp12381H381HcaCcaT44B.1.4680.022857
ORF1ab/nsp12381H381HcaCcaT44B.1.5910.042553
ORF1ab/nsp12381H381HcaCcaT44P.10.000063
ORF1ab/nsp12381H381HcaCcaT33AY.160.001139
ORF1ab/nsp12381H381HcaCcaT33AY.260.000085
ORF1ab/nsp12381H381HcaCcaT33AY.300.001187
ORF1ab/nsp12381H381HcaCcaT33AY.670.001393
ORF1ab/nsp12381H381HcaCcaT33B0.000383
ORF1ab/nsp12381H381HcaCcaT33B.1.1.2220.000612
ORF1ab/nsp12381H381HcaCcaT33B.1.360.000438
ORF1ab/nsp12381H381HcaCcaT33B.1.4270.000151
ORF1ab/nsp12381H381HcaCcaT33B.1.617.10.000387
ORF1ab/nsp12381H381HcaCcaT33P.20.00056
ORF1ab/nsp12381H381HcaCcaT22AY.1060.00067
ORF1ab/nsp12381H381HcaCcaT22AY.1130.000285
ORF1ab/nsp12381H381HcaCcaT22AY.1140.000462
ORF1ab/nsp12381H381HcaCcaT22AY.1160.000574
ORF1ab/nsp12381H381HcaCcaT22AY.4.40.000818
ORF1ab/nsp12381H381HcaCcaT22AY.610.00021
ORF1ab/nsp12381H381HcaCcaT22AY.640.00119
ORF1ab/nsp12381H381HcaCcaT22AY.840.000875
ORF1ab/nsp12381H381HcaCcaT22AY.9.10.000167
ORF1ab/nsp12381H381HcaCcaT22AY.920.000575
ORF1ab/nsp12381H381HcaCcaT22AY.99.10.003106
ORF1ab/nsp12381H381HcaCcaT22B.1.1.1700.002494
ORF1ab/nsp12381H381HcaCcaT22B.1.1.3120.003824
ORF1ab/nsp12381H381HcaCcaT22B.1.36.270.001527
ORF1ab/nsp12381H381HcaCcaT22B.1.3690.00057
ORF1ab/nsp12381H381HcaCcaT22B.1.5250.000226
ORF1ab/nsp12381H381HcaCcaT22B.1.6090.000959
ORF1ab/nsp12381H381HcaCcaT22B.1.80.003945
ORF1ab/nsp12381H381HcaCcaT22C.36.3.10.005435
ORF1ab/nsp12381H381HcaCcaT11AY.1080.001103
ORF1ab/nsp12381H381HcaCcaT11AY.1210.000135
ORF1ab/nsp12381H381HcaCcaT11AY.130.000161
ORF1ab/nsp12381H381HcaCcaT11AY.140.000088
ORF1ab/nsp12381H381HcaCcaT11AY.270.000065
ORF1ab/nsp12381H381HcaCcaT11AY.330.000067
ORF1ab/nsp12381H381HcaCcaT11AY.34.10.00051
ORF1ab/nsp12381H381HcaCcaT11AY.370.000316
ORF1ab/nsp12381H381HcaCcaT11AY.4.50.000107
ORF1ab/nsp12381H381HcaCcaT11AY.400.000964
ORF1ab/nsp12381H381HcaCcaT11AY.46.10.001027
ORF1ab/nsp12381H381HcaCcaT11AY.46.20.000635
ORF1ab/nsp12381H381HcaCcaT11AY.5.40.000277
ORF1ab/nsp12381H381HcaCcaT11AY.60.000041
ORF1ab/nsp12381H381HcaCcaT11AY.600.000938
ORF1ab/nsp12381H381HcaCcaT11AY.700.000209
ORF1ab/nsp12381H381HcaCcaT11AY.740.000116
ORF1ab/nsp12381H381HcaCcaT11AY.750.000056
ORF1ab/nsp12381H381HcaCcaT11AY.9.20.000037
ORF1ab/nsp12381H381HcaCcaT11AY.910.00073
ORF1ab/nsp12381H381HcaCcaT11AY.940.000443
ORF1ab/nsp12381H381HcaCcaT11AY.980.000079
ORF1ab/nsp12381H381HcaCcaT11AY.990.001049
ORF1ab/nsp12381H381HcaCcaT11B.1.1.2650.003155
ORF1ab/nsp12381H381HcaCcaT11B.1.1.2750.011236
ORF1ab/nsp12381H381HcaCcaT11B.1.1.280.000311
ORF1ab/nsp12381H381HcaCcaT11B.1.1.3390.010526
ORF1ab/nsp12381H381HcaCcaT11B.1.1.3890.006061
ORF1ab/nsp12381H381HcaCcaT11B.1.1.5070.008696
ORF1ab/nsp12381H381HcaCcaT11B.1.1570.002985
ORF1ab/nsp12381H381HcaCcaT11B.1.177.570.000281
ORF1ab/nsp12381H381HcaCcaT11B.1.177.60.000977
ORF1ab/nsp12381H381HcaCcaT11B.1.177.600.000218
ORF1ab/nsp12381H381HcaCcaT11B.1.177.650.000665
ORF1ab/nsp12381H381HcaCcaT11B.1.177.70.000165
ORF1ab/nsp12381H381HcaCcaT11B.1.177.750.001041
ORF1ab/nsp12381H381HcaCcaT11B.1.177.870.000728
ORF1ab/nsp12381H381HcaCcaT11B.1.2060.000816
ORF1ab/nsp12381H381HcaCcaT11B.1.2210.000071
ORF1ab/nsp12381H381HcaCcaT11B.1.2340.000132
ORF1ab/nsp12381H381HcaCcaT11B.1.2430.00007
ORF1ab/nsp12381H381HcaCcaT11B.1.258.160.001637
ORF1ab/nsp12381H381HcaCcaT11B.1.258.170.000104
ORF1ab/nsp12381H381HcaCcaT11B.1.3110.000275
ORF1ab/nsp12381H381HcaCcaT11B.1.3890.001002
ORF1ab/nsp12381H381HcaCcaT11B.1.4110.003704
ORF1ab/nsp12381H381HcaCcaT11B.1.4290.000024
ORF1ab/nsp12381H381HcaCcaT11B.1.438.10.000107
ORF1ab/nsp12381H381HcaCcaT11B.1.5610.000397
ORF1ab/nsp12381H381HcaCcaT11B.1.5640.000426
ORF1ab/nsp12381H381HcaCcaT11B.1.5760.000907
ORF1ab/nsp12381H381HcaCcaT11B.1.5960.000087
ORF1ab/nsp12381H381HcaCcaT11C.1.20.004255
ORF1ab/nsp12381H381HcaCcaT11L.10.001905
ORF1ab/nsp12381H381HcaCcaT11P.1.160.000374
ORF1ab/nsp12381H381HcaCcaT11P.1.60.001946
ORF1ab/nsp12381H381HcaCcaT11Q.10.000126
ORF1ab/nsp12381H381HcaCcaT11Q.20.000613

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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