CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = A4A

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp124A4AA4396AsyngcAgcG3112620.84244413451-13453
ORF1ab/nsp124A4AA4396AsyngcAgcC311370.11897113451-13453
ORF1ab/nsp124A4AA4396AsyngcAgcT311120.038585213451-13453

Details of the mutation A4A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp124A4AgcAgcG262311All0.00005
ORF1ab/nsp124A4AgcAgcC37311All0.000007
ORF1ab/nsp124A4AgcAgcT12311All0.000002
ORF1ab/nsp124A4AgcAgcG7272AY.1040.142857
ORF1ab/nsp124A4AgcAgcG3839B.1.617.20.000143
ORF1ab/nsp124A4AgcAgcC139B.1.617.20.000004
ORF1ab/nsp124A4AgcAgcG2125AY.40.000033
ORF1ab/nsp124A4AgcAgcC425AY.40.000006
ORF1ab/nsp124A4AgcAgcG1919AY.30.000189
ORF1ab/nsp124A4AgcAgcG1519B.1.1.70.000013
ORF1ab/nsp124A4AgcAgcC219B.1.1.70.000002
ORF1ab/nsp124A4AgcAgcT219B.1.1.70.000002
ORF1ab/nsp124A4AgcAgcG1919B.1.36.220.022947
ORF1ab/nsp124A4AgcAgcC1818B.1.10.000327
ORF1ab/nsp124A4AgcAgcG1010AY.1030.000062
ORF1ab/nsp124A4AgcAgcG1010B.1.3510.000297
ORF1ab/nsp124A4AgcAgcG1010B.1.621.10.005058
ORF1ab/nsp124A4AgcAgcG88AY.980.000632
ORF1ab/nsp124A4AgcAgcT68B.1.4290.000141
ORF1ab/nsp124A4AgcAgcG18B.1.4290.000024
ORF1ab/nsp124A4AgcAgcC18B.1.4290.000024
ORF1ab/nsp124A4AgcAgcG25AY.250.000012
ORF1ab/nsp124A4AgcAgcT25AY.250.000012
ORF1ab/nsp124A4AgcAgcC15AY.250.000006
ORF1ab/nsp124A4AgcAgcG55AY.99.20.000461
ORF1ab/nsp124A4AgcAgcG44AY.440.000024
ORF1ab/nsp124A4AgcAgcG44B.1.36.10.004561
ORF1ab/nsp124A4AgcAgcG33B.1.258.170.000312
ORF1ab/nsp124A4AgcAgcC23P.10.000032
ORF1ab/nsp124A4AgcAgcT13P.10.000016
ORF1ab/nsp124A4AgcAgcG22AY.390.000049
ORF1ab/nsp124A4AgcAgcG22AY.430.000009
ORF1ab/nsp124A4AgcAgcC22B.1.1.5210.010695
ORF1ab/nsp124A4AgcAgcG22B.1.177.120.000303
ORF1ab/nsp124A4AgcAgcC11A0.000387
ORF1ab/nsp124A4AgcAgcG11AY.1050.000643
ORF1ab/nsp124A4AgcAgcC11AY.1180.000063
ORF1ab/nsp124A4AgcAgcG11AY.190.00114
ORF1ab/nsp124A4AgcAgcG11AY.340.000097
ORF1ab/nsp124A4AgcAgcG11AY.350.000233
ORF1ab/nsp124A4AgcAgcG11AY.360.000148
ORF1ab/nsp124A4AgcAgcG11AY.46.60.000072
ORF1ab/nsp124A4AgcAgcG11AY.50.000021
ORF1ab/nsp124A4AgcAgcG11AY.900.000684
ORF1ab/nsp124A4AgcAgcG11B.10.000009
ORF1ab/nsp124A4AgcAgcC11B.1.1.3720.000689
ORF1ab/nsp124A4AgcAgcC11B.1.1.630.000386
ORF1ab/nsp124A4AgcAgcG11B.1.1.700.000341
ORF1ab/nsp124A4AgcAgcG11B.1.1600.000031
ORF1ab/nsp124A4AgcAgcC11B.1.177.680.015152
ORF1ab/nsp124A4AgcAgcG11B.1.3370.005587
ORF1ab/nsp124A4AgcAgcG11B.1.360.000146
ORF1ab/nsp124A4AgcAgcT11B.1.5960.000087
ORF1ab/nsp124A4AgcAgcG11B.1.6370.000073
ORF1ab/nsp124A4AgcAgcG11B.400.000364
ORF1ab/nsp124A4AgcAgcC11P.1.140.000048

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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