CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = A443V

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp12	443	A443V	A4835V	nonsyn	gCt	gTt	1376	1376	1	14767-14769

Details of the mutation A443V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp12	443	A443V	gCt	gTt	1376	1376	All	0.000263
ORF1ab/nsp12	443	A443V	gCt	gTt	241	241	B.1.1.7	0.000216
ORF1ab/nsp12	443	A443V	gCt	gTt	117	117	B.1.1.291	0.08686
ORF1ab/nsp12	443	A443V	gCt	gTt	113	113	B.1.621	0.010003
ORF1ab/nsp12	443	A443V	gCt	gTt	106	106	AY.4	0.000165
ORF1ab/nsp12	443	A443V	gCt	gTt	75	75	B.1.617.2	0.000282
ORF1ab/nsp12	443	A443V	gCt	gTt	70	70	B.1.595	0.018267
ORF1ab/nsp12	443	A443V	gCt	gTt	61	61	B.1	0.000559
ORF1ab/nsp12	443	A443V	gCt	gTt	44	44	B.1.561	0.017467
ORF1ab/nsp12	443	A443V	gCt	gTt	38	38	AY.44	0.000231
ORF1ab/nsp12	443	A443V	gCt	gTt	32	32	B.1.2	0.000282
ORF1ab/nsp12	443	A443V	gCt	gTt	26	26	B.1.623	0.013948
ORF1ab/nsp12	443	A443V	gCt	gTt	24	24	B.1.177	0.000316
ORF1ab/nsp12	443	A443V	gCt	gTt	23	23	D.2	0.001726
ORF1ab/nsp12	443	A443V	gCt	gTt	22	22	AJ.1	1
ORF1ab/nsp12	443	A443V	gCt	gTt	21	21	AD.1	0.08642
ORF1ab/nsp12	443	A443V	gCt	gTt	17	17	P.1	0.000268
ORF1ab/nsp12	443	A443V	gCt	gTt	16	16	AY.25	0.000096
ORF1ab/nsp12	443	A443V	gCt	gTt	15	15	AY.41	0.004409
ORF1ab/nsp12	443	A443V	gCt	gTt	14	14	AY.43	0.000062
ORF1ab/nsp12	443	A443V	gCt	gTt	14	14	AY.98.1	0.000678
ORF1ab/nsp12	443	A443V	gCt	gTt	13	13	AY.3	0.000129
ORF1ab/nsp12	443	A443V	gCt	gTt	13	13	AY.39	0.000321
ORF1ab/nsp12	443	A443V	gCt	gTt	11	11	B.1.1.519	0.000437
ORF1ab/nsp12	443	A443V	gCt	gTt	11	11	B.1.258.14	0.010784
ORF1ab/nsp12	443	A443V	gCt	gTt	9	9	B.1.1	0.000163
ORF1ab/nsp12	443	A443V	gCt	gTt	8	8	A.2.5	0.003992
ORF1ab/nsp12	443	A443V	gCt	gTt	8	8	AY.103	0.00005
ORF1ab/nsp12	443	A443V	gCt	gTt	8	8	B.1.587	0.01518
ORF1ab/nsp12	443	A443V	gCt	gTt	7	7	AY.46.6	0.000505
ORF1ab/nsp12	443	A443V	gCt	gTt	7	7	B.1.409	0.005469
ORF1ab/nsp12	443	A443V	gCt	gTt	7	7	B.1.429	0.000165
ORF1ab/nsp12	443	A443V	gCt	gTt	6	6	B.1.517	0.002562
ORF1ab/nsp12	443	A443V	gCt	gTt	5	5	AY.102	0.000133
ORF1ab/nsp12	443	A443V	gCt	gTt	5	5	AY.119	0.000177
ORF1ab/nsp12	443	A443V	gCt	gTt	5	5	AY.24	0.002155
ORF1ab/nsp12	443	A443V	gCt	gTt	5	5	B.1.1.294	0.006329
ORF1ab/nsp12	443	A443V	gCt	gTt	5	5	B.1.1.311	0.001791
ORF1ab/nsp12	443	A443V	gCt	gTt	5	5	B.1.258.11	0.001982
ORF1ab/nsp12	443	A443V	gCt	gTt	5	5	B.1.351	0.000149
ORF1ab/nsp12	443	A443V	gCt	gTt	5	5	B.1.596	0.000436
ORF1ab/nsp12	443	A443V	gCt	gTt	5	5	B.1.617.1	0.000645
ORF1ab/nsp12	443	A443V	gCt	gTt	4	4	AY.20	0.000155
ORF1ab/nsp12	443	A443V	gCt	gTt	4	4	AY.29	0.000063
ORF1ab/nsp12	443	A443V	gCt	gTt	4	4	B.1.526	0.000094
ORF1ab/nsp12	443	A443V	gCt	gTt	3	3	AY.110	0.000338
ORF1ab/nsp12	443	A443V	gCt	gTt	3	3	AY.26	0.000085
ORF1ab/nsp12	443	A443V	gCt	gTt	3	3	AY.33	0.0002
ORF1ab/nsp12	443	A443V	gCt	gTt	3	3	AY.34	0.000291
ORF1ab/nsp12	443	A443V	gCt	gTt	3	3	B.1.1.222	0.000612
ORF1ab/nsp12	443	A443V	gCt	gTt	3	3	B.1.1.429	0.013825
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	AY.121	0.000271
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	AY.46	0.000208
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	AY.6	0.000082
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	AY.61	0.00021
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.1.231	0.006192
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.1.28	0.000622
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.1.284	0.000215
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.1.303	0.005525
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.1.63	0.000772
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.110.3	0.001437
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.243	0.000139
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.250	0.028986
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.311	0.000549
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.375	0.001639
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	B.1.588	0.00182
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	C.36	0.001821
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	P.1.15	0.000465
ORF1ab/nsp12	443	A443V	gCt	gTt	2	2	R.1	0.00018
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	A	0.000387
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	A.28	0.002646
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AE.5	0.018519
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.100	0.000046
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.113	0.000142
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.120	0.000037
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.120.1	0.000321
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.27	0.000065
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.29.1	0.000221
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.3.1	0.000085
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.4.2	0.000022
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.40	0.000964
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.42	0.00004
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.54	0.000095
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.7	0.000196
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.74	0.000116
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.85	0.000427
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.9	0.000068
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.9.2	0.000037
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.91	0.00073
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.96	0.002075
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.98	0.000079
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.99	0.001049
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.99.1	0.001553
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	AY.99.2	0.000092
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.216	0.00089
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.218	0.007692
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.25	0.000569
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.265	0.003155
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.273	0.006757
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.274	0.005051
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.285	0.006536
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.306	0.000438
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.317	0.000412
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.356	0.008547
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.416	0.000905
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.57	0.011494
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.61	0.008772
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.1.83	0.00271
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.139	0.000733
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.147	0.000756
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.160	0.000031
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.177.35	0.000691
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.177.60	0.000218
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.177.65	0.000665
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.177.73	0.000566
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.177.79	0.002342
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.221	0.000071
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.258	0.000067
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.325	0.006897
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.338	0.008621
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.349	0.000715
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.36.8	0.001
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.377	0.004566
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.400	0.000429
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.525	0.000113
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.609	0.000479
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.627	0.00202
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.1.637	0.000073
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	B.55	0.00295
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	C.16	0.00106
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	L.3	0.003546
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	P.1.12	0.000484
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	P.1.14	0.000048
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	P.1.17	0.000162
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	P.6	0.003145
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	P.7	0.004367
ORF1ab/nsp12	443	A443V	gCt	gTt	1	1	Q.8	0.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.