CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = A253V

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12253A253VA4645VnonsyngCagTa82770.93902414197-14199
ORF1ab/nsp12253A253VA4645VnonsyngCAgTT8240.048780514197-14199
ORF1ab/nsp12253A253VA4645VnonsyngCAgTG8210.012195114197-14199

Details of the mutation A253V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12253A253VgCagTa7782All0.000015
ORF1ab/nsp12253A253VgCAgTT482All0.000001
ORF1ab/nsp12253A253VgCAgTG182All0
ORF1ab/nsp12253A253VgCagTa1616AY.40.000025
ORF1ab/nsp12253A253VgCagTa88B.1.1.70.000007
ORF1ab/nsp12253A253VgCagTa77B.10.000064
ORF1ab/nsp12253A253VgCagTa44B.1.617.20.000015
ORF1ab/nsp12253A253VgCagTa44B.400.001457
ORF1ab/nsp12253A253VgCagTa33A0.001161
ORF1ab/nsp12253A253VgCagTa33A.250.054545
ORF1ab/nsp12253A253VgCAgTT23AY.30.00002
ORF1ab/nsp12253A253VgCagTa13AY.30.00001
ORF1ab/nsp12253A253VgCagTa33B.1.5960.000261
ORF1ab/nsp12253A253VgCAgTG120.055556
ORF1ab/nsp12253A253VgCagTa120.055556
ORF1ab/nsp12253A253VgCagTa22AY.1190.000071
ORF1ab/nsp12253A253VgCagTa22B.1.1770.000026
ORF1ab/nsp12253A253VgCagTa22B.1.20.000018
ORF1ab/nsp12253A253VgCagTa22B.1.4290.000047
ORF1ab/nsp12253A253VgCagTa11AY.1020.000027
ORF1ab/nsp12253A253VgCagTa11AY.1030.000006
ORF1ab/nsp12253A253VgCagTa11AY.16.10.00047
ORF1ab/nsp12253A253VgCagTa11AY.230.00007
ORF1ab/nsp12253A253VgCagTa11AY.250.000006
ORF1ab/nsp12253A253VgCAgTT11AY.390.000025
ORF1ab/nsp12253A253VgCagTa11AY.430.000004
ORF1ab/nsp12253A253VgCagTa11AY.9.10.000084
ORF1ab/nsp12253A253VgCAgTT11AY.960.002075
ORF1ab/nsp12253A253VgCagTa11AY.980.000079
ORF1ab/nsp12253A253VgCagTa11B.1.10.000018
ORF1ab/nsp12253A253VgCagTa11B.1.1.2160.00089
ORF1ab/nsp12253A253VgCagTa11B.1.1.2220.000204
ORF1ab/nsp12253A253VgCagTa11B.1.1.4160.000905
ORF1ab/nsp12253A253VgCagTa11B.1.3240.001605
ORF1ab/nsp12253A253VgCagTa11B.1.4270.00005
ORF1ab/nsp12253A253VgCagTa11B.1.5880.00091
ORF1ab/nsp12253A253VgCagTa11B.1.617.10.000129
ORF1ab/nsp12253A253VgCagTa11C.10.002392
ORF1ab/nsp12253A253VgCagTa11D.20.000075
ORF1ab/nsp12253A253VgCagTa11P.1.140.000048

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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