CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : CodonNum = 821 & Codon = Gaa

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp12	821	K821E	K5213E	nonsyn	Aaa	Gaa	25	25	1	15901-15903

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp12	821	K821E	Aaa	Gaa	25	25	All	0.000005
ORF1ab/nsp12	821	K821E	Aaa	Gaa	7	7	B.1.258	0.000466
ORF1ab/nsp12	821	K821E	Aaa	Gaa	6	6	AY.29	0.000095
ORF1ab/nsp12	821	K821E	Aaa	Gaa	2	2	AY.58	0.001815
ORF1ab/nsp12	821	K821E	Aaa	Gaa	2	2	Q.1	0.000253
ORF1ab/nsp12	821	K821E	Aaa	Gaa	1	1	AY.103	0.000006
ORF1ab/nsp12	821	K821E	Aaa	Gaa	1	1	AY.4	0.000002
ORF1ab/nsp12	821	K821E	Aaa	Gaa	1	1	AY.9.1	0.000084
ORF1ab/nsp12	821	K821E	Aaa	Gaa	1	1	B.1	0.000009
ORF1ab/nsp12	821	K821E	Aaa	Gaa	1	1	B.1.1.39	0.00051
ORF1ab/nsp12	821	K821E	Aaa	Gaa	1	1	B.1.367	0.000792
ORF1ab/nsp12	821	K821E	Aaa	Gaa	1	1	B.1.617.2	0.000004
ORF1ab/nsp12	821	K821E	Aaa	Gaa	1	1	B.3	0.000831

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.