CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : CodonNum = 274

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12274D274DD4666DsyngaCgaT62216221114260-14262
ORF1ab/nsp12274D274ED4666EnonsyngaCgaA24230.95833314260-14262
ORF1ab/nsp12274D274ED4666EnonsyngaCgaG2410.041666714260-14262
ORF1ab/nsp12274D274YD4666YnonsynGacTac1919114260-14262
ORF1ab/nsp12274D274ND4666NnonsynGacAac15140.93333314260-14262
ORF1ab/nsp12274D274ND4666NnonsynGaCAaT1510.066666714260-14262
ORF1ab/nsp12274D274delD4666deldelGAC---99114260-14262
ORF1ab/nsp12274D274VD4666VnonsyngAcgTc44114260-14262
ORF1ab/nsp12274D274GD4666GnonsyngAcgGc22114260-14262
ORF1ab/nsp12274D274TD4666TnonsynGACACT210.514260-14262
ORF1ab/nsp12274D274AD4666AnonsyngAcgCc210.514260-14262
ORF1ab/nsp12274D274AD4666AnonsyngACgCT210.514260-14262
ORF1ab/nsp12274D274TD4666TnonsynGAcACc210.514260-14262
ORF1ab/nsp12274D274HD4666HnonsynGacCac11114260-14262

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12274D274DgaCgaT62216221All0.00119
ORF1ab/nsp12274D274DgaCgaT26892689B.1.617.20.010125
ORF1ab/nsp12274D274DgaCgaT12331233R.10.110981
ORF1ab/nsp12274D274DgaCgaT394394B.1.1.70.000353
ORF1ab/nsp12274D274DgaCgaT315315B.1.1.5190.012509
ORF1ab/nsp12274D274DgaCgaT168168B.10.001539
ORF1ab/nsp12274D274DgaCgaT109109B.1.619.10.069917
ORF1ab/nsp12274D274DgaCgaT9999B.1.3510.002943
ORF1ab/nsp12274D274DgaCgaT8585AY.40.000132
ORF1ab/nsp12274D274DgaCgaT8484AY.400.081003
ORF1ab/nsp12274D274DgaCgaT7676AY.430.000337
ORF1ab/nsp12274D274DgaCgaT5151AY.1030.000317
ORF1ab/nsp12274D274DgaCgaT4545AY.250.000271
ORF1ab/nsp12274D274DgaCgaT4343AY.310.796296
ORF1ab/nsp12274D274DgaCgaT4040B.1.240.11
ORF1ab/nsp12274D274DgaCgaT3939B.1.20.000343
ORF1ab/nsp12274D274DgaCgaT2929AY.290.000457
ORF1ab/nsp12274D274DgaCgaT2727AY.16.10.012688
ORF1ab/nsp12274D274DgaCgaT2525B.1.3600.316456
ORF1ab/nsp12274D274EgaCgaA2324All0.000004
ORF1ab/nsp12274D274EgaCgaG124All0
ORF1ab/nsp12274D274DgaCgaT2424B.1.10.000435
ORF1ab/nsp12274D274DgaCgaT2424B.1.2210.001705
ORF1ab/nsp12274D274DgaCgaT2222AY.130.003542
ORF1ab/nsp12274D274DgaCgaT2222AY.440.000134
ORF1ab/nsp12274D274DgaCgaT2020B0.002556
ORF1ab/nsp12274D274YGacTac1919All0.000004
ORF1ab/nsp12274D274DgaCgaT1818AY.540.001716
ORF1ab/nsp12274D274DgaCgaT1818AY.750.001008
ORF1ab/nsp12274D274DgaCgaT1717AY.680.004654
ORF1ab/nsp12274D274DgaCgaT1717B.1.1.3370.061151
ORF1ab/nsp12274D274DgaCgaT1616AY.470.000498
ORF1ab/nsp12274D274NGacAac1415All0.000003
ORF1ab/nsp12274D274NGaCAaT115All0
ORF1ab/nsp12274D274DgaCgaT1515AY.260.000425
ORF1ab/nsp12274D274DgaCgaT1515B.1.2430.001044
ORF1ab/nsp12274D274DgaCgaT1313B.1.1600.000405
ORF1ab/nsp12274D274DgaCgaT1111AY.610.001153
ORF1ab/nsp12274D274DgaCgaT1111P.10.000173
ORF1ab/nsp12274D274DgaCgaT1010AY.1020.000265
ORF1ab/nsp12274D274DgaCgaT1010AY.650.00533
ORF1ab/nsp12274D274DgaCgaT1010AY.90.000676
ORF1ab/nsp12274D274DgaCgaT1010B.1.3320.034965
ORF1ab/nsp12274D274delGAC---99All0.000002
ORF1ab/nsp12274D274DgaCgaT99AY.370.002845
ORF1ab/nsp12274D274DgaCgaT99AY.410.002646
ORF1ab/nsp12274D274DgaCgaT99AY.75.10.001623
ORF1ab/nsp12274D274DgaCgaT99AY.770.010147
ORF1ab/nsp12274D274DgaCgaT99AY.9.20.000331
ORF1ab/nsp12274D274DgaCgaT99B.1.360.001313
ORF1ab/nsp12274D274DgaCgaT99B.1.4270.000454
ORF1ab/nsp12274D274DgaCgaT88AY.160.003037
ORF1ab/nsp12274D274DgaCgaT88AY.240.003448
ORF1ab/nsp12274D274DgaCgaT88AY.670.003714
ORF1ab/nsp12274D274DgaCgaT88B.1.177.440.004152
ORF1ab/nsp12274D274DgaCgaT88B.1.2400.001725
ORF1ab/nsp12274D274DgaCgaT77AY.1190.000247
ORF1ab/nsp12274D274DgaCgaT77AY.200.000272
ORF1ab/nsp12274D274DgaCgaT77AY.270.000453
ORF1ab/nsp12274D274DgaCgaT77AY.390.000173
ORF1ab/nsp12274D274DgaCgaT77AY.60.000288
ORF1ab/nsp12274D274DgaCgaT77B.1.1770.000092
ORF1ab/nsp12274D274EgaCgaA77B.1.617.20.000026
ORF1ab/nsp12274D274DgaCgaT66A.270.009934
ORF1ab/nsp12274D274DgaCgaT66B.1.6370.000438
ORF1ab/nsp12274D274DgaCgaT55AY.30.00005
ORF1ab/nsp12274D274DgaCgaT55AY.450.000608
ORF1ab/nsp12274D274DgaCgaT55AY.530.001438
ORF1ab/nsp12274D274DgaCgaT55AY.980.000395
ORF1ab/nsp12274D274YGacTac55B.10.000046
ORF1ab/nsp12274D274EgaCgaA55B.1.1.3180.001509
ORF1ab/nsp12274D274delGAC---55B.1.1.70.000004
ORF1ab/nsp12274D274DgaCgaT55B.1.5260.000118
ORF1ab/nsp12274D274VgAcgTc44All0.000001
ORF1ab/nsp12274D274DgaCgaT44AY.5.30.00135
ORF1ab/nsp12274D274DgaCgaT44AY.5.40.001107
ORF1ab/nsp12274D274DgaCgaT44AY.590.002119
ORF1ab/nsp12274D274DgaCgaT44AY.640.002381
ORF1ab/nsp12274D274DgaCgaT44B.1.1700.017241
ORF1ab/nsp12274D274DgaCgaT44B.1.5820.001963
ORF1ab/nsp12274D274DgaCgaT44B.1.5950.001044
ORF1ab/nsp12274D274DgaCgaT44B.1.617.10.000516
ORF1ab/nsp12274D274DgaCgaT44P.1.140.000191
ORF1ab/nsp12274D274DgaCgaT44Q.40.001819
ORF1ab/nsp12274D274DgaCgaT33AY.100.00159
ORF1ab/nsp12274D274NGacAac33AY.1030.000019
ORF1ab/nsp12274D274DgaCgaT33AY.1040.005952
ORF1ab/nsp12274D274DgaCgaT33AY.1210.000406
ORF1ab/nsp12274D274DgaCgaT33AY.190.003421
ORF1ab/nsp12274D274NGacAac33AY.40.000005
ORF1ab/nsp12274D274DgaCgaT33AY.520.002443
ORF1ab/nsp12274D274DgaCgaT33AY.710.001425
ORF1ab/nsp12274D274DgaCgaT33AY.730.001996
ORF1ab/nsp12274D274DgaCgaT33AY.850.001282
ORF1ab/nsp12274D274YGacTac33B.1.1.70.000003
ORF1ab/nsp12274D274DgaCgaT33B.1.1920.027778
ORF1ab/nsp12274D274DgaCgaT33B.1.2580.0002
ORF1ab/nsp12274D274DgaCgaT33B.1.3690.000856
ORF1ab/nsp12274D274DgaCgaT33B.1.4280.003061
ORF1ab/nsp12274D274DgaCgaT33B.1.4290.000071
ORF1ab/nsp12274D274DgaCgaT33B.1.5250.000339
ORF1ab/nsp12274D274VgAcgTc33D.20.000225
ORF1ab/nsp12274D274NGacAac120.055556
ORF1ab/nsp12274D274NGaCAaT120.055556
ORF1ab/nsp12274D274TGAcACc120.055556
ORF1ab/nsp12274D274TGACACT120.055556
ORF1ab/nsp12274D274AgACgCT120.055556
ORF1ab/nsp12274D274AgAcgCc120.055556
ORF1ab/nsp12274D274DgaCgaT22A.2.5.20.003145
ORF1ab/nsp12274D274GgAcgGc22All0
ORF1ab/nsp12274D274AgAcgCc12All0
ORF1ab/nsp12274D274TGACACT12All0
ORF1ab/nsp12274D274TGAcACc12All0
ORF1ab/nsp12274D274AgACgCT12All0
ORF1ab/nsp12274D274DgaCgaT22AY.1180.000125
ORF1ab/nsp12274D274DgaCgaT22AY.140.000176
ORF1ab/nsp12274D274DgaCgaT22AY.230.000139
ORF1ab/nsp12274D274EgaCgaA22AY.3.10.000171
ORF1ab/nsp12274D274DgaCgaT22AY.330.000134
ORF1ab/nsp12274D274delGAC---22AY.40.000003
ORF1ab/nsp12274D274DgaCgaT22AY.4.10.001475
ORF1ab/nsp12274D274YGacTac22AY.430.000009
ORF1ab/nsp12274D274DgaCgaT22AY.490.00639
ORF1ab/nsp12274D274DgaCgaT22AY.50.000041
ORF1ab/nsp12274D274DgaCgaT22AY.510.001818
ORF1ab/nsp12274D274DgaCgaT22AY.600.001876
ORF1ab/nsp12274D274DgaCgaT22AY.700.000417
ORF1ab/nsp12274D274DgaCgaT22AY.840.000875
ORF1ab/nsp12274D274DgaCgaT22AY.860.00166
ORF1ab/nsp12274D274DgaCgaT22AY.9.10.000167
ORF1ab/nsp12274D274DgaCgaT22AY.99.20.000184
ORF1ab/nsp12274D274EgaCgaA12B.10.000009
ORF1ab/nsp12274D274EgaCgaG12B.10.000009
ORF1ab/nsp12274D274DgaCgaT22B.1.1.2220.000408
ORF1ab/nsp12274D274DgaCgaT22B.1.1.250.001137
ORF1ab/nsp12274D274DgaCgaT22B.1.1.280.000622
ORF1ab/nsp12274D274DgaCgaT22B.1.1.2840.000215
ORF1ab/nsp12274D274DgaCgaT22B.1.177.330.003289
ORF1ab/nsp12274D274DgaCgaT22B.1.177.750.002081
ORF1ab/nsp12274D274NGacAac22B.1.360.000292
ORF1ab/nsp12274D274DgaCgaT22B.1.3750.001639
ORF1ab/nsp12274D274EgaCgaA22B.1.3970.009709
ORF1ab/nsp12274D274DgaCgaT22B.1.438.10.000215
ORF1ab/nsp12274D274DgaCgaT22B.1.466.20.000782
ORF1ab/nsp12274D274DgaCgaT22D.20.00015
ORF1ab/nsp12274D274DgaCgaT22P.1.150.000465
ORF1ab/nsp12274D274DgaCgaT110.055556
ORF1ab/nsp12274D274YGacTac11A0.000387
ORF1ab/nsp12274D274HGacCac11All0
ORF1ab/nsp12274D274DgaCgaT11AY.1050.000643
ORF1ab/nsp12274D274DgaCgaT11AY.1130.000142
ORF1ab/nsp12274D274DgaCgaT11AY.1140.000231
ORF1ab/nsp12274D274DgaCgaT11AY.1200.000037
ORF1ab/nsp12274D274DgaCgaT11AY.29.10.000221
ORF1ab/nsp12274D274NGacAac11AY.30.00001
ORF1ab/nsp12274D274DgaCgaT11AY.340.000097
ORF1ab/nsp12274D274DgaCgaT11AY.380.000499
ORF1ab/nsp12274D274DgaCgaT11AY.4.30.000842
ORF1ab/nsp12274D274EgaCgaA11AY.430.000004
ORF1ab/nsp12274D274YGacTac11AY.460.000104
ORF1ab/nsp12274D274YGacTac11AY.520.000814
ORF1ab/nsp12274D274DgaCgaT11AY.550.000917
ORF1ab/nsp12274D274YGacTac11AY.60.000041
ORF1ab/nsp12274D274DgaCgaT11AY.620.000436
ORF1ab/nsp12274D274DgaCgaT11AY.630.000387
ORF1ab/nsp12274D274EgaCgaA11AY.7.10.000113
ORF1ab/nsp12274D274DgaCgaT11AY.870.000833
ORF1ab/nsp12274D274DgaCgaT11AY.880.000884
ORF1ab/nsp12274D274DgaCgaT11AY.98.10.000048
ORF1ab/nsp12274D274DgaCgaT11AY.99.10.001553
ORF1ab/nsp12274D274YGacTac11B0.000128
ORF1ab/nsp12274D274delGAC---11B.1.10.000018
ORF1ab/nsp12274D274delGAC---11B.1.1.10.000327
ORF1ab/nsp12274D274DgaCgaT11B.1.1.1570.000913
ORF1ab/nsp12274D274DgaCgaT11B.1.1.2200.001859
ORF1ab/nsp12274D274EgaCgaA11B.1.1.2220.000204
ORF1ab/nsp12274D274DgaCgaT11B.1.1.2650.003155
ORF1ab/nsp12274D274DgaCgaT11B.1.1.3110.000358
ORF1ab/nsp12274D274DgaCgaT11B.1.1.330.000421
ORF1ab/nsp12274D274DgaCgaT11B.1.1.3440.010753
ORF1ab/nsp12274D274YGacTac11B.1.1.3720.000689
ORF1ab/nsp12274D274DgaCgaT11B.1.1.3910.008547
ORF1ab/nsp12274D274EgaCgaA11B.1.1.5190.00004
ORF1ab/nsp12274D274DgaCgaT11B.1.1.5250.005464
ORF1ab/nsp12274D274GgAcgGc11B.1.1.70.000001
ORF1ab/nsp12274D274DgaCgaT11B.1.130.002375
ORF1ab/nsp12274D274EgaCgaA11B.1.1470.000756
ORF1ab/nsp12274D274DgaCgaT11B.1.177.40.000211
ORF1ab/nsp12274D274DgaCgaT11B.1.177.570.000281
ORF1ab/nsp12274D274DgaCgaT11B.1.177.600.000218
ORF1ab/nsp12274D274DgaCgaT11B.1.177.620.001192
ORF1ab/nsp12274D274DgaCgaT11B.1.177.860.000183
ORF1ab/nsp12274D274VgAcgTc11B.1.20.000009
ORF1ab/nsp12274D274NGacAac11B.1.20.000009
ORF1ab/nsp12274D274DgaCgaT11B.1.2140.003663
ORF1ab/nsp12274D274HGacCac11B.1.2430.00007
ORF1ab/nsp12274D274DgaCgaT11B.1.258.120.007874
ORF1ab/nsp12274D274DgaCgaT11B.1.258.70.001912
ORF1ab/nsp12274D274YGacTac11B.1.3010.005917
ORF1ab/nsp12274D274DgaCgaT11B.1.3060.005714
ORF1ab/nsp12274D274DgaCgaT11B.1.3490.000715
ORF1ab/nsp12274D274DgaCgaT11B.1.36.290.000517
ORF1ab/nsp12274D274DgaCgaT11B.1.36.380.001642
ORF1ab/nsp12274D274YGacTac11B.1.3690.000285
ORF1ab/nsp12274D274DgaCgaT11B.1.3950.007042
ORF1ab/nsp12274D274DgaCgaT11B.1.4020.009804
ORF1ab/nsp12274D274DgaCgaT11B.1.416.10.001563
ORF1ab/nsp12274D274YGacTac11B.1.4590.004082
ORF1ab/nsp12274D274DgaCgaT11B.1.4590.004082
ORF1ab/nsp12274D274DgaCgaT11B.1.5580.004566
ORF1ab/nsp12274D274NGacAac11B.1.5800.004065
ORF1ab/nsp12274D274DgaCgaT11B.1.5960.000087
ORF1ab/nsp12274D274NGacAac11B.1.5960.000087
ORF1ab/nsp12274D274GgAcgGc11B.1.6020.006536
ORF1ab/nsp12274D274DgaCgaT11B.1.6090.000479
ORF1ab/nsp12274D274EgaCgaA11B.1.6090.000479
ORF1ab/nsp12274D274DgaCgaT11B.1.6190.000871
ORF1ab/nsp12274D274DgaCgaT11B.60.00091
ORF1ab/nsp12274D274NGacAac11C.37.10.002618
ORF1ab/nsp12274D274DgaCgaT11N.50.001767
ORF1ab/nsp12274D274DgaCgaT11P.1.120.000484
ORF1ab/nsp12274D274DgaCgaT11P.1.170.000162
ORF1ab/nsp12274D274DgaCgaT11Q.80.000165
ORF1ab/nsp12274D274DgaCgaT11Z.10.00289

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.