CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : CodonNum = 166

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12166V166VV4558VsyngtAgtG2641360.51515213936-13938
ORF1ab/nsp12166V166VV4558VsyngtAgtC264690.26136413936-13938
ORF1ab/nsp12166V166VV4558VsyngtAgtT264590.22348513936-13938
ORF1ab/nsp12166V166LV4558LnonsynGtaTta2452420.98775513936-13938
ORF1ab/nsp12166V166LV4558LnonsynGtaCta24520.0081632613936-13938
ORF1ab/nsp12166V166LV4558LnonsynGtATtG24510.0040816313936-13938
ORF1ab/nsp12166V166IV4558InonsynGtaAta60590.98333313936-13938
ORF1ab/nsp12166V166IV4558InonsynGtAAtT6010.016666713936-13938
ORF1ab/nsp12166V166delV4558deldelGTA---5959113936-13938
ORF1ab/nsp12166V166AV4558AnonsyngTagCa5757113936-13938
ORF1ab/nsp12166V166del1V4558del1delgtAgt-950.55555613936-13938
ORF1ab/nsp12166V166del1V4558del1delGta-ta940.44444413936-13938
ORF1ab/nsp12166V166EV4558EnonsyngTagAa760.85714313936-13938
ORF1ab/nsp12166V166EV4558EnonsyngTAgAG710.14285713936-13938
ORF1ab/nsp12166V166GV4558GnonsyngTagGa640.66666713936-13938
ORF1ab/nsp12166V166GV4558GnonsyngTAgGT620.33333313936-13938
ORF1ab/nsp12166V166XV4558XnonsynGTaTGa420.513936-13938
ORF1ab/nsp12166V166XV4558XnonsynGTaTAa420.513936-13938
ORF1ab/nsp12166V166DV4558DnonsyngTAgAT33113936-13938
ORF1ab/nsp12166V166FV4558FnonsynGtATtT33113936-13938
ORF1ab/nsp12166V166YV4558YnonsynGTATAT22113936-13938
ORF1ab/nsp12166V166CV4558CnonsynGTATGT11113936-13938

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12166V166VgtAgtG136264All0.000026
ORF1ab/nsp12166V166VgtAgtC69264All0.000013
ORF1ab/nsp12166V166VgtAgtT59264All0.000011
ORF1ab/nsp12166V166LGtaTta242245All0.000046
ORF1ab/nsp12166V166LGtaCta2245All0
ORF1ab/nsp12166V166LGtATtG1245All0
ORF1ab/nsp12166V166LGtaTta8282C.30.10.550336
ORF1ab/nsp12166V166IGtaAta5960All0.000011
ORF1ab/nsp12166V166IGtAAtT160All0
ORF1ab/nsp12166V166delGTA---5959All0.000011
ORF1ab/nsp12166V166AgTagCa5757All0.000011
ORF1ab/nsp12166V166VgtAgtC4747B.1.1600.001466
ORF1ab/nsp12166V166delGTA---4040AY.60.001645
ORF1ab/nsp12166V166VgtAgtG2738B.1.1.70.000024
ORF1ab/nsp12166V166VgtAgtC1138B.1.1.70.00001
ORF1ab/nsp12166V166LGtaTta3636B.1.1.5190.00143
ORF1ab/nsp12166V166VgtAgtG2533B.10.000229
ORF1ab/nsp12166V166VgtAgtC733B.10.000064
ORF1ab/nsp12166V166VgtAgtT133B.10.000009
ORF1ab/nsp12166V166LGtaTta1818B.1.1.70.000016
ORF1ab/nsp12166V166VgtAgtG1317AY.40.00002
ORF1ab/nsp12166V166VgtAgtT417AY.40.000006
ORF1ab/nsp12166V166IGtaAta1616AY.40.000025
ORF1ab/nsp12166V166VgtAgtT1415AY.330.000935
ORF1ab/nsp12166V166VgtAgtG115AY.330.000067
ORF1ab/nsp12166V166AgTagCa1313B.1.1.70.000012
ORF1ab/nsp12166V166VgtAgtT910AY.30.00009
ORF1ab/nsp12166V166VgtAgtG110AY.30.00001
ORF1ab/nsp12166V166VgtAgtG910B.1.1770.000119
ORF1ab/nsp12166V166VgtAgtC110B.1.1770.000013
ORF1ab/nsp12166V166VgtAgtG610B.1.617.20.000023
ORF1ab/nsp12166V166VgtAgtT410B.1.617.20.000015
ORF1ab/nsp12166V166del1gtAgt-59All0.000001
ORF1ab/nsp12166V166del1Gta-ta49All0.000001
ORF1ab/nsp12166V166AgTagCa99Q.40.004093
ORF1ab/nsp12166V166EgTagAa67All0.000001
ORF1ab/nsp12166V166EgTAgAG17All0
ORF1ab/nsp12166V166VgtAgtT77AY.460.000729
ORF1ab/nsp12166V166LGtaTta77B.10.000064
ORF1ab/nsp12166V166GgTagGa46All0.000001
ORF1ab/nsp12166V166GgTAgGT26All0
ORF1ab/nsp12166V166IGtaAta66AY.1030.000037
ORF1ab/nsp12166V166VgtAgtG66B.1.2580.000399
ORF1ab/nsp12166V166VgtAgtG66B.1.360.000875
ORF1ab/nsp12166V166VgtAgtT450.222222
ORF1ab/nsp12166V166VgtAgtG150.055556
ORF1ab/nsp12166V166LGtaTta55AY.40.000008
ORF1ab/nsp12166V166VgtAgtT55AY.440.00003
ORF1ab/nsp12166V166LGtaTta45B.1.10.000073
ORF1ab/nsp12166V166LGtATtG15B.1.10.000018
ORF1ab/nsp12166V166LGtaTta55B.1.1.10.001633
ORF1ab/nsp12166V166VgtAgtG45B.1.177.810.000757
ORF1ab/nsp12166V166VgtAgtC15B.1.177.810.000189
ORF1ab/nsp12166V166EgTagAa340.166667
ORF1ab/nsp12166V166EgTAgAG140.055556
ORF1ab/nsp12166V166LGtaTta44AB.10.032787
ORF1ab/nsp12166V166XGTaTGa24All0
ORF1ab/nsp12166V166XGTaTAa24All0
ORF1ab/nsp12166V166LGtaTta44AY.1030.000025
ORF1ab/nsp12166V166VgtAgtG44AY.250.000024
ORF1ab/nsp12166V166LGtaTta44AY.3.10.000341
ORF1ab/nsp12166V166VgtAgtG24AY.390.000049
ORF1ab/nsp12166V166VgtAgtT24AY.390.000049
ORF1ab/nsp12166V166IGtaAta44AY.430.000018
ORF1ab/nsp12166V166IGtaAta34B.1.1.70.000003
ORF1ab/nsp12166V166IGtAAtT14B.1.1.70.000001
ORF1ab/nsp12166V166LGtaTta44B.1.160.160.003717
ORF1ab/nsp12166V166IGtaAta44B.1.617.20.000015
ORF1ab/nsp12166V166LGtaTta330.166667
ORF1ab/nsp12166V166FGtATtT330.166667
ORF1ab/nsp12166V166DgTAgAT330.166667
ORF1ab/nsp12166V166XGTaTAa230.111111
ORF1ab/nsp12166V166XGTaTGa130.055556
ORF1ab/nsp12166V166FGtATtT33All0.000001
ORF1ab/nsp12166V166DgTAgAT33All0.000001
ORF1ab/nsp12166V166IGtaAta33AY.1000.000138
ORF1ab/nsp12166V166VgtAgtG33AY.1030.000019
ORF1ab/nsp12166V166IGtaAta33AY.440.000018
ORF1ab/nsp12166V166VgtAgtG33AY.750.000168
ORF1ab/nsp12166V166GgTagGa23B.10.000018
ORF1ab/nsp12166V166GgTAgGT13B.10.000009
ORF1ab/nsp12166V166LGtaTta33B.1.1.2140.000166
ORF1ab/nsp12166V166VgtAgtT33B.1.1.3120.005736
ORF1ab/nsp12166V166delGTA---33B.1.1.70.000003
ORF1ab/nsp12166V166LGtaTta33B.1.1770.00004
ORF1ab/nsp12166V166LGtaTta33B.1.20.000026
ORF1ab/nsp12166V166LGtaTta33B.1.2430.000209
ORF1ab/nsp12166V166AgTagCa33B.1.258.160.00491
ORF1ab/nsp12166V166AgTagCa33B.1.5960.000261
ORF1ab/nsp12166V166delGTA---33B.1.617.20.000011
ORF1ab/nsp12166V166LGtaTta33P.10.000047
ORF1ab/nsp12166V166YGTATAT220.111111
ORF1ab/nsp12166V166GgTagGa120.055556
ORF1ab/nsp12166V166GgTAgGT120.055556
ORF1ab/nsp12166V166LGtaTta22A0.000774
ORF1ab/nsp12166V166YGTATAT22All0
ORF1ab/nsp12166V166AgTagCa22AY.1030.000012
ORF1ab/nsp12166V166LGtaTta22AY.1210.000271
ORF1ab/nsp12166V166delGTA---22AY.250.000012
ORF1ab/nsp12166V166LGtaTta22AY.250.000012
ORF1ab/nsp12166V166delGTA---22AY.260.000057
ORF1ab/nsp12166V166IGtaAta22AY.260.000057
ORF1ab/nsp12166V166VgtAgtG22AY.260.000057
ORF1ab/nsp12166V166VgtAgtG22AY.4.20.000043
ORF1ab/nsp12166V166LGtaTta22AY.440.000012
ORF1ab/nsp12166V166VgtAgtG22AY.470.000062
ORF1ab/nsp12166V166LGtaTta22AY.610.00021
ORF1ab/nsp12166V166IGtaAta22AY.7.10.000225
ORF1ab/nsp12166V166IGtaAta22B.10.000018
ORF1ab/nsp12166V166AgTagCa22B.10.000018
ORF1ab/nsp12166V166VgtAgtG12B.1.10.000018
ORF1ab/nsp12166V166VgtAgtT12B.1.10.000018
ORF1ab/nsp12166V166EgTagAa22B.1.1.70.000002
ORF1ab/nsp12166V166del1gtAgt-12B.1.1.70.000001
ORF1ab/nsp12166V166del1Gta-ta12B.1.1.70.000001
ORF1ab/nsp12166V166LGtaTta22B.1.1260.002551
ORF1ab/nsp12166V166AgTagCa22B.1.1600.000062
ORF1ab/nsp12166V166LGtaTta22B.1.1600.000062
ORF1ab/nsp12166V166AgTagCa22B.1.160.80.002577
ORF1ab/nsp12166V166IGtaAta22B.1.1770.000026
ORF1ab/nsp12166V166AgTagCa22B.1.177.210.000153
ORF1ab/nsp12166V166AgTagCa22B.1.177.420.001789
ORF1ab/nsp12166V166AgTagCa22B.1.20.000018
ORF1ab/nsp12166V166LGtaTta22B.1.2210.000142
ORF1ab/nsp12166V166LGtaTta22B.1.3510.000059
ORF1ab/nsp12166V166LGtaTta22B.1.4270.000101
ORF1ab/nsp12166V166IGtaAta22B.1.5260.000047
ORF1ab/nsp12166V166VgtAgtT22B.1.617.10.000258
ORF1ab/nsp12166V166LGtaTta22B.1.617.10.000258
ORF1ab/nsp12166V166LGtaTta22B.1.6210.000177
ORF1ab/nsp12166V166VgtAgtT12P.1.10.000318
ORF1ab/nsp12166V166VgtAgtC12P.1.10.000318
ORF1ab/nsp12166V166CGTATGT110.055556
ORF1ab/nsp12166V166CGTATGT11All0
ORF1ab/nsp12166V166VgtAgtG11AY.1000.000046
ORF1ab/nsp12166V166IGtaAta11AY.1020.000027
ORF1ab/nsp12166V166AgTagCa11AY.1020.000027
ORF1ab/nsp12166V166LGtaTta11AY.1140.000231
ORF1ab/nsp12166V166VgtAgtG11AY.1170.000085
ORF1ab/nsp12166V166IGtaAta11AY.1180.000063
ORF1ab/nsp12166V166IGtaAta11AY.1210.000135
ORF1ab/nsp12166V166VgtAgtG11AY.140.000088
ORF1ab/nsp12166V166IGtaAta11AY.200.000039
ORF1ab/nsp12166V166VgtAgtG11AY.200.000039
ORF1ab/nsp12166V166VgtAgtG11AY.290.000016
ORF1ab/nsp12166V166LGtaTta11AY.290.000016
ORF1ab/nsp12166V166LGtaTta11AY.30.00001
ORF1ab/nsp12166V166LGtaTta11AY.300.000396
ORF1ab/nsp12166V166IGtaAta11AY.390.000025
ORF1ab/nsp12166V166LGtaTta11AY.430.000004
ORF1ab/nsp12166V166VgtAgtG11AY.430.000004
ORF1ab/nsp12166V166delGTA---11AY.430.000004
ORF1ab/nsp12166V166del1Gta-ta11AY.440.000006
ORF1ab/nsp12166V166VgtAgtG11AY.46.60.000072
ORF1ab/nsp12166V166VgtAgtG11AY.50.000021
ORF1ab/nsp12166V166LGtaTta11AY.50.000021
ORF1ab/nsp12166V166VgtAgtG11AY.590.00053
ORF1ab/nsp12166V166IGtaAta11AY.630.000387
ORF1ab/nsp12166V166LGtaTta11AY.750.000056
ORF1ab/nsp12166V166VgtAgtG11AY.90.000068
ORF1ab/nsp12166V166LGtaTta11AY.9.20.000037
ORF1ab/nsp12166V166LGtaTta11AY.98.10.000048
ORF1ab/nsp12166V166AgTagCa11B0.000128
ORF1ab/nsp12166V166del1gtAgt-11B0.000128
ORF1ab/nsp12166V166delGTA---11B.10.000009
ORF1ab/nsp12166V166delGTA---11B.1.1.10.000327
ORF1ab/nsp12166V166delGTA---11B.1.1.1390.022727
ORF1ab/nsp12166V166LGtaTta11B.1.1.1940.00495
ORF1ab/nsp12166V166AgTagCa11B.1.1.2140.000055
ORF1ab/nsp12166V166VgtAgtG11B.1.1.2160.00089
ORF1ab/nsp12166V166LGtaCta11B.1.1.2320.001815
ORF1ab/nsp12166V166VgtAgtT11B.1.1.280.000311
ORF1ab/nsp12166V166AgTagCa11B.1.1.2840.000107
ORF1ab/nsp12166V166LGtaTta11B.1.1.2880.001916
ORF1ab/nsp12166V166LGtaTta11B.1.1.3010.001179
ORF1ab/nsp12166V166AgTagCa11B.1.1.3180.000302
ORF1ab/nsp12166V166delGTA---11B.1.1.3480.000796
ORF1ab/nsp12166V166IGtaAta11B.1.1.3680.003086
ORF1ab/nsp12166V166LGtaTta11B.1.1.4340.000349
ORF1ab/nsp12166V166IGtaAta11B.1.1.5190.00004
ORF1ab/nsp12166V166LGtaTta11B.1.1.590.006494
ORF1ab/nsp12166V166AgTagCa11B.1.1040.00369
ORF1ab/nsp12166V166VgtAgtG11B.1.1170.0125
ORF1ab/nsp12166V166AgTagCa11B.1.1770.000013
ORF1ab/nsp12166V166del1Gta-ta11B.1.1770.000013
ORF1ab/nsp12166V166AgTagCa11B.1.177.450.000381
ORF1ab/nsp12166V166LGtaTta11B.1.177.50.001242
ORF1ab/nsp12166V166AgTagCa11B.1.177.520.001757
ORF1ab/nsp12166V166LGtaTta11B.1.177.600.000218
ORF1ab/nsp12166V166LGtaTta11B.1.177.860.000183
ORF1ab/nsp12166V166delGTA---11B.1.20.000009
ORF1ab/nsp12166V166del1gtAgt-11B.1.20.000009
ORF1ab/nsp12166V166LGtaTta11B.1.220.001318
ORF1ab/nsp12166V166AgTagCa11B.1.2210.000071
ORF1ab/nsp12166V166XGTaTGa11B.1.2210.000071
ORF1ab/nsp12166V166GgTagGa11B.1.2210.000071
ORF1ab/nsp12166V166LGtaTta11B.1.221.30.000833
ORF1ab/nsp12166V166AgTagCa11B.1.2340.000132
ORF1ab/nsp12166V166AgTagCa11B.1.258.110.000396
ORF1ab/nsp12166V166EgTagAa11B.1.258.170.000104
ORF1ab/nsp12166V166LGtaTta11B.1.258.170.000104
ORF1ab/nsp12166V166LGtaTta11B.1.3490.000715
ORF1ab/nsp12166V166LGtaTta11B.1.36.80.001
ORF1ab/nsp12166V166VgtAgtC11B.1.36.80.001
ORF1ab/nsp12166V166LGtaTta11B.1.3750.00082
ORF1ab/nsp12166V166delGTA---11B.1.3810.007812
ORF1ab/nsp12166V166AgTagCa11B.1.4270.00005
ORF1ab/nsp12166V166LGtaCta11B.1.4290.000024
ORF1ab/nsp12166V166VgtAgtG11B.1.4560.003268
ORF1ab/nsp12166V166AgTagCa11B.1.5090.000866
ORF1ab/nsp12166V166LGtaTta11B.1.5260.000024
ORF1ab/nsp12166V166LGtaTta11B.1.5610.000397
ORF1ab/nsp12166V166VgtAgtG11B.1.5750.000303
ORF1ab/nsp12166V166AgTagCa11B.1.5800.004065
ORF1ab/nsp12166V166VgtAgtG11B.1.6210.000089
ORF1ab/nsp12166V166VgtAgtG11B.1.940.027027
ORF1ab/nsp12166V166del1gtAgt-11B.550.00295
ORF1ab/nsp12166V166del1Gta-ta11C.30.10.006711
ORF1ab/nsp12166V166IGtaAta11C.370.000116
ORF1ab/nsp12166V166delGTA---11D.20.000075
ORF1ab/nsp12166V166VgtAgtT11D.20.000075
ORF1ab/nsp12166V166IGtaAta11D.20.000075
ORF1ab/nsp12166V166VgtAgtG11P.10.000016
ORF1ab/nsp12166V166del1gtAgt-11P.1.10.000318
ORF1ab/nsp12166V166LGtaTta11P.1.140.000048
ORF1ab/nsp12166V166VgtAgtG11P.1.170.000162
ORF1ab/nsp12166V166LGtaTta11P.30.001595
ORF1ab/nsp12166V166delGTA---11Q.10.000126

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.