CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp10 : Mut = N105N

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp10	105	N105N	N4358N	syn	aaT	aaC	1499	1499	1	13337-13339

Details of the mutation N105N within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp10	105	N105N	aaT	aaC	1499	1499	All	0.000287
ORF1ab/nsp10	105	N105N	aaT	aaC	377	377	B.1.617.2	0.00142
ORF1ab/nsp10	105	N105N	aaT	aaC	231	231	AY.39	0.005708
ORF1ab/nsp10	105	N105N	aaT	aaC	158	158	AY.98	0.012481
ORF1ab/nsp10	105	N105N	aaT	aaC	149	149	B.1.1.135	0.699531
ORF1ab/nsp10	105	N105N	aaT	aaC	130	130	B.1.1.7	0.000116
ORF1ab/nsp10	105	N105N	aaT	aaC	43	43	AY.44	0.000262
ORF1ab/nsp10	105	N105N	aaT	aaC	35	35	AY.4	0.000054
ORF1ab/nsp10	105	N105N	aaT	aaC	30	30	AY.20	0.001166
ORF1ab/nsp10	105	N105N	aaT	aaC	29	29	AY.25	0.000174
ORF1ab/nsp10	105	N105N	aaT	aaC	20	20	B.1.596	0.001743
ORF1ab/nsp10	105	N105N	aaT	aaC	16	16	B.1	0.000147
ORF1ab/nsp10	105	N105N	aaT	aaC	15	15	AY.43	0.000066
ORF1ab/nsp10	105	N105N	aaT	aaC	15	15	B.1.1.392	0.789474
ORF1ab/nsp10	105	N105N	aaT	aaC	15	15	P.1.14	0.000717
ORF1ab/nsp10	105	N105N	aaT	aaC	13	13	B.1.258	0.000865
ORF1ab/nsp10	105	N105N	aaT	aaC	12	12	B.1.497	0.003777
ORF1ab/nsp10	105	N105N	aaT	aaC	12	12	B.1.637	0.000877
ORF1ab/nsp10	105	N105N	aaT	aaC	11	11	B.1.36.8	0.011
ORF1ab/nsp10	105	N105N	aaT	aaC	10	10	AY.103	0.000062
ORF1ab/nsp10	105	N105N	aaT	aaC	10	10	AY.5	0.000206
ORF1ab/nsp10	105	N105N	aaT	aaC	9	9	B.1.1.241	0.018634
ORF1ab/nsp10	105	N105N	aaT	aaC	8	8	AY.4.2	0.000174
ORF1ab/nsp10	105	N105N	aaT	aaC	8	8	B.1.1.214	0.000444
ORF1ab/nsp10	105	N105N	aaT	aaC	8	8	B.1.2	0.00007
ORF1ab/nsp10	105	N105N	aaT	aaC	7	7	AY.26	0.000198
ORF1ab/nsp10	105	N105N	aaT	aaC	7	7	B.1.1	0.000127
ORF1ab/nsp10	105	N105N	aaT	aaC	6	6	AY.102	0.000159
ORF1ab/nsp10	105	N105N	aaT	aaC	6	6	B.1.575	0.00182
ORF1ab/nsp10	105	N105N	aaT	aaC	5	5	AY.120	0.000186
ORF1ab/nsp10	105	N105N	aaT	aaC	4	4	C.36.3	0.002269
ORF1ab/nsp10	105	N105N	aaT	aaC	4	4	R.1	0.00036
ORF1ab/nsp10	105	N105N	aaT	aaC	3	3	AY.118	0.000188
ORF1ab/nsp10	105	N105N	aaT	aaC	3	3	AY.29	0.000047
ORF1ab/nsp10	105	N105N	aaT	aaC	3	3	AY.40	0.002893
ORF1ab/nsp10	105	N105N	aaT	aaC	3	3	B.1.628	0.001057
ORF1ab/nsp10	105	N105N	aaT	aaC	3	3	C.37	0.000348
ORF1ab/nsp10	105	N105N	aaT	aaC	3	3	P.1	0.000047
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	AY.101	0.000981
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	AY.119	0.000071
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	AY.14	0.000176
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	AY.16	0.000759
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	AY.39.1	0.000079
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	AY.46.6	0.000144
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	AY.9.2	0.000073
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	AY.99.2	0.000184
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	B.1.1.398	0.006452
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	B.1.1.519	0.000079
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	B.1.258.17	0.000208
ORF1ab/nsp10	105	N105N	aaT	aaC	2	2	B.1.351	0.000059
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.107	0.000466
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.121	0.000135
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.13	0.000161
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.16.1	0.00047
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.19	0.00114
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.27	0.000065
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.33	0.000067
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.37	0.000316
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.4.2.1	0.000149
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.42	0.00004
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.46.2	0.000635
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.54	0.000095
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.6	0.000041
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.67	0.000464
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.70	0.000209
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.75	0.000056
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.75.1	0.00018
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.84	0.000437
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.9.1	0.000084
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.92	0.000287
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	AY.95	0.000761
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.1.10	0.001115
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.1.284	0.000107
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.1.33	0.000421
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.1.50	0.000679
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.160	0.000031
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.177	0.000013
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.177.4	0.000211
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.177.7	0.000165
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.177.81	0.000189
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.177.86	0.000183
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.210	0.002132
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.234	0.000132
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.281	0.021739
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.36	0.000146
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.36.31	0.001751
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.36.7	0.004
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.367	0.000792
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.427	0.00005
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.429	0.000024
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.438.1	0.000107
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.456	0.003268
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.466.2	0.000391
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.561	0.000397
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.582	0.000491
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.627	0.00202
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.1.9.4	0.006135
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	B.6	0.00091
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	C.14	0.004329
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	P.1.17.1	0.000875
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	P.2	0.000187
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	Q.1	0.000126
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	Q.3	0.000145
ORF1ab/nsp10	105	N105N	aaT	aaC	1	1	Q.8	0.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.