CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp1 : Mut = L149L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp1149L149LL149LsynctTctC9207110.772826710-712
ORF1ab/nsp1149L149LL149LsynctTctA9201000.108696710-712
ORF1ab/nsp1149L149LL149LsynctTctG920600.0652174710-712
ORF1ab/nsp1149L149LL149LsynCtTTtG920320.0347826710-712
ORF1ab/nsp1149L149LL149LsynCtTTtA920170.0184783710-712

Details of the mutation L149L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp1149L149LctTctC711920All0.000136
ORF1ab/nsp1149L149LctTctA100920All0.000019
ORF1ab/nsp1149L149LctTctG60920All0.000011
ORF1ab/nsp1149L149LCtTTtG32920All0.000006
ORF1ab/nsp1149L149LCtTTtA17920All0.000003
ORF1ab/nsp1149L149LctTctC331331AY.4.50.03558
ORF1ab/nsp1149L149LctTctC9696AY.30.000955
ORF1ab/nsp1149L149LctTctC3295B.1.1.70.000029
ORF1ab/nsp1149L149LCtTTtG1995B.1.1.70.000017
ORF1ab/nsp1149L149LctTctA1895B.1.1.70.000016
ORF1ab/nsp1149L149LctTctG1795B.1.1.70.000015
ORF1ab/nsp1149L149LCtTTtA995B.1.1.70.000008
ORF1ab/nsp1149L149LctTctC6666AY.570.043307
ORF1ab/nsp1149L149LctTctA3538P.10.000551
ORF1ab/nsp1149L149LctTctC238P.10.000032
ORF1ab/nsp1149L149LctTctG138P.10.000016
ORF1ab/nsp1149L149LctTctG1130B.10.000101
ORF1ab/nsp1149L149LCtTTtG930B.10.000082
ORF1ab/nsp1149L149LCtTTtA430B.10.000037
ORF1ab/nsp1149L149LctTctC330B.10.000027
ORF1ab/nsp1149L149LctTctA330B.10.000027
ORF1ab/nsp1149L149LctTctC2529AY.40.000039
ORF1ab/nsp1149L149LctTctA329AY.40.000005
ORF1ab/nsp1149L149LctTctG129AY.40.000002
ORF1ab/nsp1149L149LctTctC2626AZ.10.02255
ORF1ab/nsp1149L149LctTctG2125AY.46.60.001516
ORF1ab/nsp1149L149LctTctA425AY.46.60.000289
ORF1ab/nsp1149L149LctTctC1314AY.250.000078
ORF1ab/nsp1149L149LctTctA114AY.250.000006
ORF1ab/nsp1149L149LctTctC1113B.1.20.000097
ORF1ab/nsp1149L149LCtTTtA113B.1.20.000009
ORF1ab/nsp1149L149LctTctA113B.1.20.000009
ORF1ab/nsp1149L149LctTctC1212B.1.177.290.8
ORF1ab/nsp1149L149LctTctC1111AY.640.006548
ORF1ab/nsp1149L149LctTctC1111B.1.1600.000343
ORF1ab/nsp1149L149LctTctC910B.1.617.20.000034
ORF1ab/nsp1149L149LctTctA110B.1.617.20.000004
ORF1ab/nsp1149L149LctTctA48AY.430.000018
ORF1ab/nsp1149L149LctTctC48AY.430.000018
ORF1ab/nsp1149L149LctTctC66AY.330.000401
ORF1ab/nsp1149L149LctTctC66N.20.230769
ORF1ab/nsp1149L149LctTctC55AY.440.00003
ORF1ab/nsp1149L149LctTctA45B.1.6210.000354
ORF1ab/nsp1149L149LctTctC15B.1.6210.000089
ORF1ab/nsp1149L149LctTctA14B.1.1.10.000327
ORF1ab/nsp1149L149LCtTTtG14B.1.1.10.000327
ORF1ab/nsp1149L149LCtTTtA14B.1.1.10.000327
ORF1ab/nsp1149L149LctTctG14B.1.1.10.000327
ORF1ab/nsp1149L149LctTctA24B.1.1770.000026
ORF1ab/nsp1149L149LctTctG14B.1.1770.000013
ORF1ab/nsp1149L149LCtTTtG14B.1.1770.000013
ORF1ab/nsp1149L149LCtTTtG14B.1.4170.028571
ORF1ab/nsp1149L149LctTctG14B.1.4170.028571
ORF1ab/nsp1149L149LctTctA14B.1.4170.028571
ORF1ab/nsp1149L149LCtTTtA14B.1.4170.028571
ORF1ab/nsp1149L149LctTctC33AY.50.000062
ORF1ab/nsp1149L149LctTctC33AY.750.000168
ORF1ab/nsp1149L149LctTctC13B.1.10.000018
ORF1ab/nsp1149L149LCtTTtA13B.1.10.000018
ORF1ab/nsp1149L149LctTctA13B.1.10.000018
ORF1ab/nsp1149L149LctTctA33B.1.1.250.001706
ORF1ab/nsp1149L149LctTctC33B.1.4040.003906
ORF1ab/nsp1149L149LctTctA23B.1.4290.000047
ORF1ab/nsp1149L149LctTctC13B.1.4290.000024
ORF1ab/nsp1149L149LctTctG33R.10.00027
ORF1ab/nsp1149L149LctTctA22AY.1020.000053
ORF1ab/nsp1149L149LctTctC22AY.1030.000012
ORF1ab/nsp1149L149LctTctC22AY.200.000078
ORF1ab/nsp1149L149LctTctC22AY.260.000057
ORF1ab/nsp1149L149LctTctA22AY.300.000791
ORF1ab/nsp1149L149LctTctC22AY.450.000243
ORF1ab/nsp1149L149LctTctG12AY.9.10.000084
ORF1ab/nsp1149L149LctTctC12AY.9.10.000084
ORF1ab/nsp1149L149LctTctC22B.1.1.5190.000079
ORF1ab/nsp1149L149LctTctA22B.1.2320.001075
ORF1ab/nsp1149L149LCtTTtG12B.1.2580.000067
ORF1ab/nsp1149L149LctTctG12B.1.2580.000067
ORF1ab/nsp1149L149LctTctC11A.180.05
ORF1ab/nsp1149L149LctTctA11AY.1000.000046
ORF1ab/nsp1149L149LctTctC11AY.1180.000063
ORF1ab/nsp1149L149LctTctC11AY.1200.000037
ORF1ab/nsp1149L149LctTctC11AY.120.10.000321
ORF1ab/nsp1149L149LctTctC11AY.230.00007
ORF1ab/nsp1149L149LctTctC11AY.270.000065
ORF1ab/nsp1149L149LctTctC11AY.3.10.000085
ORF1ab/nsp1149L149LctTctC11AY.4.20.000022
ORF1ab/nsp1149L149LctTctC11AY.530.000288
ORF1ab/nsp1149L149LctTctA11AY.90.000068
ORF1ab/nsp1149L149LctTctC11AY.98.10.000048
ORF1ab/nsp1149L149LctTctA11B.1.1.280.000311
ORF1ab/nsp1149L149LctTctC11B.1.1.2840.000107
ORF1ab/nsp1149L149LctTctC11B.1.1.3180.000302
ORF1ab/nsp1149L149LctTctC11B.1.1.330.000421
ORF1ab/nsp1149L149LctTctA11B.1.1100.004525
ORF1ab/nsp1149L149LctTctA11B.1.177.810.000189
ORF1ab/nsp1149L149LctTctC11B.1.2430.00007
ORF1ab/nsp1149L149LctTctC11B.1.36.290.000517
ORF1ab/nsp1149L149LctTctG11B.1.4270.00005
ORF1ab/nsp1149L149LctTctC11B.1.5240.001406
ORF1ab/nsp1149L149LctTctC11B.1.5250.000113
ORF1ab/nsp1149L149LctTctA11B.1.5960.000087
ORF1ab/nsp1149L149LctTctA11B.1.6250.002353
ORF1ab/nsp1149L149LctTctC11B.1.6280.000352
ORF1ab/nsp1149L149LctTctC11C.170.055556
ORF1ab/nsp1149L149LctTctA11D.20.000075
ORF1ab/nsp1149L149LctTctA11P.1.140.000048
ORF1ab/nsp1149L149LctTctA11Q.80.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.