CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp1 : Mut = D147E

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp1147D147ED147EnonsyngaCgaA1551030.664516704-706
ORF1ab/nsp1147D147ED147EnonsyngaCgaG155520.335484704-706

Details of the mutation D147E within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp1147D147EgaCgaA103155All0.00002
ORF1ab/nsp1147D147EgaCgaG52155All0.00001
ORF1ab/nsp1147D147EgaCgaA3553B.10.000321
ORF1ab/nsp1147D147EgaCgaG1853B.10.000165
ORF1ab/nsp1147D147EgaCgaA1222B.1.1.70.000011
ORF1ab/nsp1147D147EgaCgaG1022B.1.1.70.000009
ORF1ab/nsp1147D147EgaCgaA69B.1.1770.000079
ORF1ab/nsp1147D147EgaCgaG39B.1.1770.00004
ORF1ab/nsp1147D147EgaCgaA47B.1.2580.000266
ORF1ab/nsp1147D147EgaCgaG37B.1.2580.0002
ORF1ab/nsp1147D147EgaCgaG36B.1.10.000054
ORF1ab/nsp1147D147EgaCgaA36B.1.10.000054
ORF1ab/nsp1147D147EgaCgaA56B.1.20.000044
ORF1ab/nsp1147D147EgaCgaG16B.1.20.000009
ORF1ab/nsp1147D147EgaCgaA33AY.1130.000427
ORF1ab/nsp1147D147EgaCgaA33AY.50.000062
ORF1ab/nsp1147D147EgaCgaA23B.1.1.3850.008929
ORF1ab/nsp1147D147EgaCgaG13B.1.1.3850.004464
ORF1ab/nsp1147D147EgaCgaA33B.1.177.440.001557
ORF1ab/nsp1147D147EgaCgaG23B.1.2210.000142
ORF1ab/nsp1147D147EgaCgaA13B.1.2210.000071
ORF1ab/nsp1147D147EgaCgaA33B.1.617.20.000011
ORF1ab/nsp1147D147EgaCgaA22AY.30.00002
ORF1ab/nsp1147D147EgaCgaA12B.1.1.10.000327
ORF1ab/nsp1147D147EgaCgaG12B.1.1.10.000327
ORF1ab/nsp1147D147EgaCgaG12B.1.1.390.00051
ORF1ab/nsp1147D147EgaCgaA12B.1.1.390.00051
ORF1ab/nsp1147D147EgaCgaG12B.1.1.700.000341
ORF1ab/nsp1147D147EgaCgaA12B.1.1.700.000341
ORF1ab/nsp1147D147EgaCgaA12B.1.1600.000031
ORF1ab/nsp1147D147EgaCgaG12B.1.1600.000031
ORF1ab/nsp1147D147EgaCgaA12B.1.2220.001692
ORF1ab/nsp1147D147EgaCgaG12B.1.2220.001692
ORF1ab/nsp1147D147EgaCgaA12B.1.4370.020833
ORF1ab/nsp1147D147EgaCgaG12B.1.4370.020833
ORF1ab/nsp1147D147EgaCgaG11AY.1030.000006
ORF1ab/nsp1147D147EgaCgaA11AY.140.000088
ORF1ab/nsp1147D147EgaCgaA11AY.240.000431
ORF1ab/nsp1147D147EgaCgaA11AY.270.000065
ORF1ab/nsp1147D147EgaCgaA11AY.40.000002
ORF1ab/nsp1147D147EgaCgaA11AY.430.000004
ORF1ab/nsp1147D147EgaCgaA11B.1.1.1700.001247
ORF1ab/nsp1147D147EgaCgaG11B.1.1.3170.000412
ORF1ab/nsp1147D147EgaCgaA11B.1.1.4480.002033
ORF1ab/nsp1147D147EgaCgaA11B.1.177.210.000076
ORF1ab/nsp1147D147EgaCgaA11B.1.177.230.003236
ORF1ab/nsp1147D147EgaCgaA11B.1.177.750.001041
ORF1ab/nsp1147D147EgaCgaA11B.1.177.860.000183
ORF1ab/nsp1147D147EgaCgaA11B.1.36.80.001
ORF1ab/nsp1147D147EgaCgaG11B.1.6090.000479
ORF1ab/nsp1147D147EgaCgaG11B.1.780.008547
ORF1ab/nsp1147D147EgaCgaA11B.1.90.006173
ORF1ab/nsp1147D147EgaCgaA11C.300.001727
ORF1ab/nsp1147D147EgaCgaG11P.10.000016
ORF1ab/nsp1147D147EgaCgaA11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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