CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp1 : CodonNum = 37 & Codon = Aag
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp1 | 37 | E37K | E37K | nonsyn | Gag | Aag | 2026 | 2026 | 1 | 374-376 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2026 | 2026 | All | 0.000387 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 520 | 520 | B.1.1.7 | 0.000466 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 378 | 378 | B.1.177.15 | 0.238486 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 150 | 150 | B.1.429 | 0.003529 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 130 | 130 | AA.2 | 1 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 110 | 110 | AA.4 | 1 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 109 | 109 | AA.7 | 1 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 62 | 62 | AA.5 | 1 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 62 | 62 | AA.6 | 1 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 62 | 62 | AY.5 | 0.00128 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 55 | 55 | AY.43 | 0.000244 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 44 | 44 | A.1 | 0.012401 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 38 | 38 | AY.70 | 0.007923 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 37 | 37 | AA.3 | 1 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 27 | 27 | B.1.221 | 0.001918 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 24 | 24 | B.1.617.2 | 0.00009 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 18 | 18 | AY.4 | 0.000028 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 17 | 17 | B.1.2 | 0.00015 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 16 | 16 | B.1.177 | 0.000211 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 14 | 14 | B.1 | 0.000128 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 11 | 11 | AY.103 | 0.000068 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 11 | 11 | B.1.526 | 0.000259 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 10 | 10 | B.1.621 | 0.000885 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 9 | 9 | AY.25 | 0.000054 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 9 | 9 | AY.44 | 0.000055 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 6 | 6 | AA.1 | 0.043478 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 6 | 6 | AY.100 | 0.000276 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 6 | 6 | AY.46 | 0.000624 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 5 | 5 | B.1.1.396 | 0.227273 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 4 | 4 | AY.3 | 0.00004 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 4 | 4 | D.2 | 0.0003 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 3 | 3 | AY.39 | 0.000074 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 3 | 3 | AY.45 | 0.000365 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 3 | 3 | B.1.351 | 0.000089 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | AY.106 | 0.00067 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | AY.29 | 0.000032 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | AY.47 | 0.000062 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | AY.98 | 0.000158 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | B.1.1.28 | 0.000622 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | B.1.1.39 | 0.001019 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | B.1.1.74 | 0.008621 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | B.1.160 | 0.000062 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | B.1.596 | 0.000174 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | C.36.3.1 | 0.005435 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | P.1 | 0.000032 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 2 | 2 | P.1.14 | 0.000096 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | AY.107 | 0.000466 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | AY.113 | 0.000142 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | AY.15 | 0.002222 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | AY.42 | 0.00004 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | AY.55 | 0.000917 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | AY.93 | 0.000273 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.1.121 | 0.002427 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.1.294 | 0.001266 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.111 | 0.001175 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.139 | 0.000733 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.149 | 0.003425 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.177.21 | 0.000076 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.177.31 | 0.011494 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.177.44 | 0.000519 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.177.54 | 0.000606 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.177.56 | 0.000668 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.177.60 | 0.000218 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.177.65 | 0.000665 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.177.7 | 0.000165 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.36.17 | 0.000494 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.375 | 0.00082 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.415.1 | 0.007576 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.462 | 0.007246 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | L.1 | 0.001905 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | P.1.15 | 0.000232 |
| ORF1ab/nsp1 | 37 | E37K | Gag | Aag | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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