CoV-GLUE | Mutations | Mutation
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
N | 247 | T247I | nonsyn | aCt | aTt | 1918 | 1918 | 1 | 29012-29014 |
Details of the mutation T247I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
N | 247 | T247I | aCt | aTt | 1918 | 1918 | All | 0.000367 |
N | 247 | T247I | aCt | aTt | 305 | 305 | B.1.637 | 0.022287 |
N | 247 | T247I | aCt | aTt | 189 | 189 | B.1.1.7 | 0.000169 |
N | 247 | T247I | aCt | aTt | 157 | 157 | B.1.443 | 0.733645 |
N | 247 | T247I | aCt | aTt | 151 | 151 | AY.4 | 0.000235 |
N | 247 | T247I | aCt | aTt | 78 | 78 | B.1.526 | 0.001833 |
N | 247 | T247I | aCt | aTt | 65 | 65 | B.1 | 0.000595 |
N | 247 | T247I | aCt | aTt | 58 | 58 | AY.14 | 0.005105 |
N | 247 | T247I | aCt | aTt | 57 | 57 | AY.25 | 0.000343 |
N | 247 | T247I | aCt | aTt | 56 | 56 | AY.44 | 0.000341 |
N | 247 | T247I | aCt | aTt | 51 | 51 | B.1.258.11 | 0.020214 |
N | 247 | T247I | aCt | aTt | 49 | 49 | B.1.604 | 0.844828 |
N | 247 | T247I | aCt | aTt | 44 | 44 | B.1.612 | 0.116711 |
N | 247 | T247I | aCt | aTt | 44 | 44 | B.40 | 0.016029 |
N | 247 | T247I | aCt | aTt | 41 | 41 | AY.103 | 0.000255 |
N | 247 | T247I | aCt | aTt | 41 | 41 | B.1.1.214 | 0.002274 |
N | 247 | T247I | aCt | aTt | 38 | 38 | B.1.617.2 | 0.000143 |
N | 247 | T247I | aCt | aTt | 33 | 33 | AY.74 | 0.003816 |
N | 247 | T247I | aCt | aTt | 32 | 32 | B.1.1 | 0.000581 |
N | 247 | T247I | aCt | aTt | 24 | 24 | P.1.1 | 0.007624 |
N | 247 | T247I | aCt | aTt | 22 | 22 | AD.2 | 0.004817 |
N | 247 | T247I | aCt | aTt | 16 | 16 | B.1.234 | 0.002111 |
N | 247 | T247I | aCt | aTt | 15 | 15 | B.1.243 | 0.001044 |
N | 247 | T247I | aCt | aTt | 15 | 15 | B.1.429 | 0.000353 |
N | 247 | T247I | aCt | aTt | 13 | 13 | AY.26 | 0.000368 |
N | 247 | T247I | aCt | aTt | 13 | 13 | AY.3 | 0.000129 |
N | 247 | T247I | aCt | aTt | 13 | 13 | AY.9.2 | 0.000477 |
N | 247 | T247I | aCt | aTt | 12 | 12 | AY.5 | 0.000248 |
N | 247 | T247I | aCt | aTt | 11 | 11 | B.1.2 | 0.000097 |
N | 247 | T247I | aCt | aTt | 10 | 10 | B.1.177 | 0.000132 |
N | 247 | T247I | aCt | aTt | 9 | 9 | B.1.160 | 0.000281 |
N | 247 | T247I | aCt | aTt | 9 | 9 | P.1.14 | 0.00043 |
N | 247 | T247I | aCt | aTt | 8 | 8 | AY.100 | 0.000368 |
N | 247 | T247I | aCt | aTt | 8 | 8 | AY.9.1 | 0.00067 |
N | 247 | T247I | aCt | aTt | 8 | 8 | B.1.1.519 | 0.000318 |
N | 247 | T247I | aCt | aTt | 8 | 8 | C.35 | 0.006192 |
N | 247 | T247I | aCt | aTt | 7 | 7 | AY.29 | 0.00011 |
N | 247 | T247I | aCt | aTt | 7 | 7 | AY.39 | 0.000173 |
N | 247 | T247I | aCt | aTt | 7 | 7 | AY.43 | 0.000031 |
N | 247 | T247I | aCt | aTt | 6 | 6 | AY.102 | 0.000159 |
N | 247 | T247I | aCt | aTt | 5 | 5 | AY.46 | 0.00052 |
N | 247 | T247I | aCt | aTt | 5 | 5 | B.1.1.486 | 0.007886 |
N | 247 | T247I | aCt | aTt | 5 | 5 | B.1.91 | 0.010373 |
N | 247 | T247I | aCt | aTt | 5 | 5 | P.1 | 0.000079 |
N | 247 | T247I | aCt | aTt | 4 | 4 | AY.108 | 0.00441 |
N | 247 | T247I | aCt | aTt | 4 | 4 | AY.34 | 0.000388 |
N | 247 | T247I | aCt | aTt | 4 | 4 | AY.42 | 0.000161 |
N | 247 | T247I | aCt | aTt | 4 | 4 | AY.47 | 0.000124 |
N | 247 | T247I | aCt | aTt | 4 | 4 | AY.6 | 0.000165 |
N | 247 | T247I | aCt | aTt | 4 | 4 | AY.64 | 0.002381 |
N | 247 | T247I | aCt | aTt | 4 | 4 | B.1.1.277 | 0.003035 |
N | 247 | T247I | aCt | aTt | 4 | 4 | B.1.425 | 0.011976 |
N | 247 | T247I | aCt | aTt | 4 | 4 | B.1.427 | 0.000202 |
N | 247 | T247I | aCt | aTt | 4 | 4 | D.2 | 0.0003 |
N | 247 | T247I | aCt | aTt | 3 | 3 | AY.4.5 | 0.000322 |
N | 247 | T247I | aCt | aTt | 3 | 3 | AY.59 | 0.001589 |
N | 247 | T247I | aCt | aTt | 3 | 3 | AY.61 | 0.000314 |
N | 247 | T247I | aCt | aTt | 3 | 3 | AY.7.1 | 0.000338 |
N | 247 | T247I | aCt | aTt | 3 | 3 | B | 0.000383 |
N | 247 | T247I | aCt | aTt | 3 | 3 | B.1.1.207 | 0.003546 |
N | 247 | T247I | aCt | aTt | 3 | 3 | B.1.258 | 0.0002 |
N | 247 | T247I | aCt | aTt | 3 | 3 | B.1.369 | 0.000856 |
N | 247 | T247I | aCt | aTt | 3 | 3 | B.1.561 | 0.001191 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AU.2 | 0.004843 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AY.109 | 0.001479 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AY.119 | 0.000071 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AY.16 | 0.000759 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AY.33 | 0.000134 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AY.36 | 0.000296 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AY.45 | 0.000243 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AY.49 | 0.00639 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AY.54 | 0.000191 |
N | 247 | T247I | aCt | aTt | 2 | 2 | AY.9 | 0.000135 |
N | 247 | T247I | aCt | aTt | 2 | 2 | B.1.1.148 | 0.017544 |
N | 247 | T247I | aCt | aTt | 2 | 2 | B.1.1.244 | 0.030769 |
N | 247 | T247I | aCt | aTt | 2 | 2 | B.1.1.315 | 0.016949 |
N | 247 | T247I | aCt | aTt | 2 | 2 | B.1.177.17 | 0.001642 |
N | 247 | T247I | aCt | aTt | 2 | 2 | B.1.258.17 | 0.000208 |
N | 247 | T247I | aCt | aTt | 2 | 2 | B.1.36 | 0.000292 |
N | 247 | T247I | aCt | aTt | 2 | 2 | B.1.555 | 0.044444 |
N | 247 | T247I | aCt | aTt | 2 | 2 | B.1.9 | 0.012346 |
N | 247 | T247I | aCt | aTt | 2 | 2 | C.36.3 | 0.001134 |
N | 247 | T247I | aCt | aTt | 2 | 2 | P.1.17 | 0.000324 |
N | 247 | T247I | aCt | aTt | 2 | 2 | P.5 | 0.027397 |
N | 247 | T247I | aCt | aTt | 1 | 1 | A | 0.000387 |
N | 247 | T247I | aCt | aTt | 1 | 1 | A.2.5 | 0.000499 |
N | 247 | T247I | aCt | aTt | 1 | 1 | A.3 | 0.002096 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.105 | 0.000643 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.12 | 0.000316 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.120 | 0.000037 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.20 | 0.000039 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.27 | 0.000065 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.3.1 | 0.000085 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.30 | 0.000396 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.34.1 | 0.00051 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.39.1 | 0.00004 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.39.2 | 0.001541 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.4.2.1 | 0.000149 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.55 | 0.000917 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.7 | 0.000196 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.70 | 0.000209 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.87 | 0.000833 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AY.98 | 0.000079 |
N | 247 | T247I | aCt | aTt | 1 | 1 | AZ.1 | 0.000867 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.1.157 | 0.000913 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.1.16 | 0.055556 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.1.291 | 0.000742 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.1.294 | 0.001266 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.1.306 | 0.000438 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.1.329 | 0.003846 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.1.430 | 0.041667 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.1.464 | 0.001473 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.1.523 | 0.001563 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.140 | 0.018868 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.177.35 | 0.000691 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.177.57 | 0.000281 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.177.63 | 0.002703 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.177.7 | 0.000165 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.177.81 | 0.000189 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.195 | 0.005025 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.214 | 0.003663 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.220 | 0.01087 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.221.1 | 0.002907 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.23 | 0.006061 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.236 | 0.002053 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.260 | 0.003344 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.281 | 0.021739 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.349 | 0.000715 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.36.36 | 0.000602 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.36.39 | 0.002217 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.395 | 0.007042 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.433 | 0.003195 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.44 | 0.008333 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.538 | 0.008065 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.575 | 0.000303 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.589 | 0.007576 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.609 | 0.000479 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.617.1 | 0.000129 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.1.623 | 0.000536 |
N | 247 | T247I | aCt | aTt | 1 | 1 | B.61 | 0.005747 |
N | 247 | T247I | aCt | aTt | 1 | 1 | C.37 | 0.000116 |
N | 247 | T247I | aCt | aTt | 1 | 1 | C.37.1 | 0.002618 |
N | 247 | T247I | aCt | aTt | 1 | 1 | P.2 | 0.000187 |
CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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