CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = N : Mut = S235L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
N	235	S235L		nonsyn	TCt	CTt	672	484	0.720238	28976-28978
N	235	S235L		nonsyn	tCT	tTG	672	123	0.183036	28976-28978
N	235	S235L		nonsyn	tCT	tTA	672	64	0.0952381	28976-28978
N	235	S235L		nonsyn	TCT	CTG	672	1	0.0014881	28976-28978

Details of the mutation S235L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
N	235	S235L	TCt	CTt	484	672	All	0.000093
N	235	S235L	tCT	tTG	123	672	All	0.000024
N	235	S235L	tCT	tTA	64	672	All	0.000012
N	235	S235L	TCT	CTG	1	672	All	0
N	235	S235L	TCt	CTt	482	668	B.1.1.7	0.000431
N	235	S235L	tCT	tTG	122	668	B.1.1.7	0.000109
N	235	S235L	tCT	tTA	64	668	B.1.1.7	0.000057
N	235	S235L	TCT	CTG	1	2	AY.3	0.00001
N	235	S235L	TCt	CTt	1	2	AY.3	0.00001
N	235	S235L	TCt	CTt	1	1		0.055556
N	235	S235L	tCT	tTG	1	1	B.1.221	0.000071

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.