CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = N : Mut = S197L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
N	197	S197L		nonsyn	tCa	tTa	7824	7823	0.999872	28862-28864
N	197	S197L		nonsyn	TCa	CTa	7824	1	0.000127812	28862-28864

Details of the mutation S197L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
N	197	S197L	tCa	tTa	7823	7824	All	0.001496
N	197	S197L	TCa	CTa	1	7824	All	0
N	197	S197L	tCa	tTa	1950	1950	A.2.5	0.973054
N	197	S197L	tCa	tTa	1464	1464	A.2	0.968895
N	197	S197L	tCa	tTa	952	952	B.1.499	1
N	197	S197L	tCa	tTa	727	727	AY.4	0.001132
N	197	S197L	tCa	tTa	622	622	A.2.5.2	0.977987
N	197	S197L	tCa	tTa	578	578	A.2.2	0.976351
N	197	S197L	tCa	tTa	293	293	A.2.4	0.986532
N	197	S197L	tCa	tTa	207	207	A.2.3	0.981043
N	197	S197L	tCa	tTa	207	207	A.2.5.1	0.995192
N	197	S197L	tCa	tTa	114	114	B.1.177.86	0.020914
N	197	S197L	tCa	tTa	100	100	B.1.576	0.090662
N	197	S197L	tCa	tTa	95	95	A.2.5.3	0.979381
N	197	S197L	tCa	tTa	56	56	B.1	0.000513
N	197	S197L	tCa	tTa	54	54	B.1.1.7	0.000048
N	197	S197L	tCa	tTa	47	47	B.1.617.2	0.000177
N	197	S197L	tCa	tTa	34	34	AY.103	0.000211
N	197	S197L	tCa	tTa	30	30	AY.25	0.00018
N	197	S197L	tCa	tTa	17	17	C.37	0.001973
N	197	S197L	tCa	tTa	14	14	AY.9.1	0.001172
N	197	S197L	tCa	tTa	14	14	B.1.2	0.000123
N	197	S197L	tCa	tTa	14	14	B.1.526	0.000329
N	197	S197L	tCa	tTa	13	13	AY.3	0.000129
N	197	S197L	tCa	tTa	11	11	B.1.409	0.008594
N	197	S197L	tCa	tTa	11	11	B.1.429	0.000259
N	197	S197L	tCa	tTa	10	10	AY.29	0.000158
N	197	S197L	tCa	tTa	9	9	B.1.499.1	1
N	197	S197L	tCa	tTa	8	8	AY.5	0.000165
N	197	S197L	tCa	tTa	7	7	AY.47	0.000218
N	197	S197L	tCa	tTa	7	7	B.1.427	0.000353
N	197	S197L	tCa	tTa	6	6	A	0.002322
N	197	S197L	tCa	tTa	6	6	AY.4.4	0.002455
N	197	S197L	tCa	tTa	6	6	AY.44	0.000037
N	197	S197L	tCa	tTa	6	6	B.1.351	0.000178
N	197	S197L	tCa	tTa	5	5	AY.4.2	0.000108
N	197	S197L	tCa	tTa	5	5	AY.43	0.000022
N	197	S197L	tCa	tTa	5	5	B.1.1	0.000091
N	197	S197L	tCa	tTa	5	5	B.1.177	0.000066
N	197	S197L	tCa	tTa	5	5	C.36	0.004554
N	197	S197L	tCa	tTa	4	4	AY.6	0.000165
N	197	S197L	tCa	tTa	4	4	B.1.1.37	0.000771
N	197	S197L	tCa	tTa	4	4	B.1.1.519	0.000159
N	197	S197L	tCa	tTa	4	4	B.1.239	0.004884
N	197	S197L	tCa	tTa	4	4	B.1.525	0.000453
N	197	S197L	tCa	tTa	4	4	P.1	0.000063
N	197	S197L	tCa	tTa	3	3	AY.23	0.000209
N	197	S197L	tCa	tTa	3	3	B	0.000383
N	197	S197L	tCa	tTa	3	3	B.1.157	0.008955
N	197	S197L	tCa	tTa	3	3	B.1.498	0.061224
N	197	S197L	tCa	tTa	2	2	AY.119	0.000071
N	197	S197L	tCa	tTa	2	2	AY.26	0.000057
N	197	S197L	tCa	tTa	2	2	AY.39.1	0.000079
N	197	S197L	tCa	tTa	2	2	AY.42	0.00008
N	197	S197L	tCa	tTa	2	2	AY.9.2	0.000073
N	197	S197L	tCa	tTa	2	2	B.1.1.284	0.000215
N	197	S197L	tCa	tTa	2	2	B.1.1.318	0.000604
N	197	S197L	tCa	tTa	2	2	B.1.1.368	0.006173
N	197	S197L	tCa	tTa	2	2	B.1.139	0.001466
N	197	S197L	tCa	tTa	2	2	B.1.234	0.000264
N	197	S197L	tCa	tTa	2	2	B.1.258	0.000133
N	197	S197L	tCa	tTa	2	2	B.1.503	0.004975
N	197	S197L	tCa	tTa	1	2	B.1.612	0.002653
N	197	S197L	TCa	CTa	1	2	B.1.612	0.002653
N	197	S197L	tCa	tTa	2	2	B.1.621	0.000177
N	197	S197L	tCa	tTa	2	2	B.40	0.000729
N	197	S197L	tCa	tTa	2	2	D.2	0.00015
N	197	S197L	tCa	tTa	2	2	P.1.15	0.000465
N	197	S197L	tCa	tTa	2	2	P.1.16	0.000748
N	197	S197L	tCa	tTa	1	1		0.055556
N	197	S197L	tCa	tTa	1	1	A.3	0.002096
N	197	S197L	tCa	tTa	1	1	AD.2	0.000219
N	197	S197L	tCa	tTa	1	1	AY.101	0.00049
N	197	S197L	tCa	tTa	1	1	AY.102	0.000027
N	197	S197L	tCa	tTa	1	1	AY.106	0.000335
N	197	S197L	tCa	tTa	1	1	AY.118	0.000063
N	197	S197L	tCa	tTa	1	1	AY.23.1	0.000417
N	197	S197L	tCa	tTa	1	1	AY.4.5	0.000107
N	197	S197L	tCa	tTa	1	1	AY.61	0.000105
N	197	S197L	tCa	tTa	1	1	B.1.1.205	0.003717
N	197	S197L	tCa	tTa	1	1	B.1.1.210	0.005714
N	197	S197L	tCa	tTa	1	1	B.1.1.216	0.00089
N	197	S197L	tCa	tTa	1	1	B.1.1.222	0.000204
N	197	S197L	tCa	tTa	1	1	B.1.1.305	0.003861
N	197	S197L	tCa	tTa	1	1	B.1.1.311	0.000358
N	197	S197L	tCa	tTa	1	1	B.1.1.33	0.000421
N	197	S197L	tCa	tTa	1	1	B.1.1.456	0.055556
N	197	S197L	tCa	tTa	1	1	B.1.1.54	0.003021
N	197	S197L	tCa	tTa	1	1	B.1.160	0.000031
N	197	S197L	tCa	tTa	1	1	B.1.177.21	0.000076
N	197	S197L	tCa	tTa	1	1	B.1.177.44	0.000519
N	197	S197L	tCa	tTa	1	1	B.1.177.60	0.000218
N	197	S197L	tCa	tTa	1	1	B.1.201	0.005682
N	197	S197L	tCa	tTa	1	1	B.1.285	0.090909
N	197	S197L	tCa	tTa	1	1	B.1.311	0.000275
N	197	S197L	tCa	tTa	1	1	B.1.330	0.028571
N	197	S197L	tCa	tTa	1	1	B.1.351.2	0.000303
N	197	S197L	tCa	tTa	1	1	B.1.354	0.043478
N	197	S197L	tCa	tTa	1	1	B.1.356	0.001727
N	197	S197L	tCa	tTa	1	1	B.1.367	0.000792
N	197	S197L	tCa	tTa	1	1	B.1.380	0.006623
N	197	S197L	tCa	tTa	1	1	B.1.542	0.03125
N	197	S197L	tCa	tTa	1	1	B.1.571	0.009709
N	197	S197L	tCa	tTa	1	1	B.1.595	0.000261
N	197	S197L	tCa	tTa	1	1	B.1.623	0.000536
N	197	S197L	tCa	tTa	1	1	B.1.633	0.041667
N	197	S197L	tCa	tTa	1	1	B.26	0.014706

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.