CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = N : Mut = R203L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
N	203	R203L		nonsyn	AGg	TTg	35	34	0.971429	28880-28882
N	203	R203L		nonsyn	AGg	CTg	35	1	0.0285714	28880-28882

Details of the mutation R203L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
N	203	R203L	AGg	TTg	34	35	All	0.000007
N	203	R203L	AGg	CTg	1	35	All	0
N	203	R203L	AGg	TTg	14	14	AY.103	0.000087
N	203	R203L	AGg	TTg	3	4	B.1.617.2	0.000011
N	203	R203L	AGg	CTg	1	4	B.1.617.2	0.000004
N	203	R203L	AGg	TTg	3	3	AY.61	0.000314
N	203	R203L	AGg	TTg	3	3	AY.85	0.001282
N	203	R203L	AGg	TTg	2	2	AY.39.1	0.000079
N	203	R203L	AGg	TTg	2	2	AY.4	0.000003
N	203	R203L	AGg	TTg	2	2	AY.46.6	0.000144
N	203	R203L	AGg	TTg	1	1	AY.100	0.000046
N	203	R203L	AGg	TTg	1	1	AY.120	0.000037
N	203	R203L	AGg	TTg	1	1	AY.25	0.000006
N	203	R203L	AGg	TTg	1	1	AY.4.2	0.000022
N	203	R203L	AGg	TTg	1	1	AY.46.2	0.000635

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.