CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = N : Mut = M1K

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
N	1	M1K		nonsyn	aTG	aAA	266	159	0.597744	28274-28276
N	1	M1K		nonsyn	aTg	aAg	266	107	0.402256	28274-28276

Details of the mutation M1K within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
N	1	M1K	aTG	aAA	159	266	All	0.00003
N	1	M1K	aTg	aAg	107	266	All	0.00002
N	1	M1K	aTG	aAA	134	223	P.1	0.002111
N	1	M1K	aTg	aAg	89	223	P.1	0.001402
N	1	M1K	aTg	aAg	6	12	P.1.4	0.005859
N	1	M1K	aTG	aAA	6	12	P.1.4	0.005859
N	1	M1K	aTG	aAA	8	9	P.1.12	0.003872
N	1	M1K	aTg	aAg	1	9	P.1.12	0.000484
N	1	M1K	aTg	aAg	3	6	P.1.2	0.003468
N	1	M1K	aTG	aAA	3	6	P.1.2	0.003468
N	1	M1K	aTG	aAA	3	5	P.1.15	0.000697
N	1	M1K	aTg	aAg	2	5	P.1.15	0.000465
N	1	M1K	aTG	aAA	3	3	P.1.17	0.000485
N	1	M1K	aTg	aAg	2	2		0.111111
N	1	M1K	aTG	aAA	2	2	P.1.14	0.000096
N	1	M1K	aTg	aAg	1	1	B.1.1.348	0.000796
N	1	M1K	aTg	aAg	1	1	B.1.260	0.003344
N	1	M1K	aTg	aAg	1	1	B.1.617.2	0.000004
N	1	M1K	aTg	aAg	1	1	P.1.10	0.000269

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.