CoV-GLUE | Mutations | Mutation
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
N | 374 | K374N | nonsyn | aaG | aaT | 3247 | 1835 | 0.565137 | 29393-29395 | |
N | 374 | K374N | nonsyn | aaG | aaC | 3247 | 1412 | 0.434863 | 29393-29395 |
Details of the mutation K374N within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
N | 374 | K374N | aaG | aaT | 1835 | 3247 | All | 0.000351 |
N | 374 | K374N | aaG | aaC | 1412 | 3247 | All | 0.00027 |
N | 374 | K374N | aaG | aaC | 699 | 795 | AY.4 | 0.001088 |
N | 374 | K374N | aaG | aaT | 96 | 795 | AY.4 | 0.000149 |
N | 374 | K374N | aaG | aaT | 670 | 795 | AY.43 | 0.002968 |
N | 374 | K374N | aaG | aaC | 125 | 795 | AY.43 | 0.000554 |
N | 374 | K374N | aaG | aaT | 268 | 306 | B.1.1.7 | 0.00024 |
N | 374 | K374N | aaG | aaC | 38 | 306 | B.1.1.7 | 0.000034 |
N | 374 | K374N | aaG | aaC | 111 | 190 | B.1.617.2 | 0.000418 |
N | 374 | K374N | aaG | aaT | 79 | 190 | B.1.617.2 | 0.000297 |
N | 374 | K374N | aaG | aaT | 148 | 148 | AY.25 | 0.00089 |
N | 374 | K374N | aaG | aaC | 133 | 133 | AY.74 | 0.015381 |
N | 374 | K374N | aaG | aaT | 82 | 97 | AY.103 | 0.000509 |
N | 374 | K374N | aaG | aaC | 15 | 97 | AY.103 | 0.000093 |
N | 374 | K374N | aaG | aaT | 88 | 88 | AY.12 | 0.027813 |
N | 374 | K374N | aaG | aaC | 38 | 56 | AY.44 | 0.000231 |
N | 374 | K374N | aaG | aaT | 18 | 56 | AY.44 | 0.00011 |
N | 374 | K374N | aaG | aaC | 38 | 45 | B.1.1 | 0.000689 |
N | 374 | K374N | aaG | aaT | 7 | 45 | B.1.1 | 0.000127 |
N | 374 | K374N | aaG | aaT | 37 | 38 | B.1.1.519 | 0.001469 |
N | 374 | K374N | aaG | aaC | 1 | 38 | B.1.1.519 | 0.00004 |
N | 374 | K374N | aaG | aaC | 17 | 33 | B.1.2 | 0.00015 |
N | 374 | K374N | aaG | aaT | 16 | 33 | B.1.2 | 0.000141 |
N | 374 | K374N | aaG | aaT | 28 | 28 | AY.20 | 0.001088 |
N | 374 | K374N | aaG | aaC | 23 | 24 | AY.118 | 0.001441 |
N | 374 | K374N | aaG | aaT | 1 | 24 | AY.118 | 0.000063 |
N | 374 | K374N | aaG | aaT | 22 | 24 | AY.4.2 | 0.000477 |
N | 374 | K374N | aaG | aaC | 2 | 24 | AY.4.2 | 0.000043 |
N | 374 | K374N | aaG | aaT | 23 | 23 | AY.4.5 | 0.002472 |
N | 374 | K374N | aaG | aaT | 12 | 21 | AY.102 | 0.000318 |
N | 374 | K374N | aaG | aaC | 9 | 21 | AY.102 | 0.000239 |
N | 374 | K374N | aaG | aaC | 16 | 19 | AY.33 | 0.001068 |
N | 374 | K374N | aaG | aaT | 3 | 19 | AY.33 | 0.0002 |
N | 374 | K374N | aaG | aaC | 17 | 19 | AY.47 | 0.000529 |
N | 374 | K374N | aaG | aaT | 2 | 19 | AY.47 | 0.000062 |
N | 374 | K374N | aaG | aaT | 10 | 18 | AY.5 | 0.000206 |
N | 374 | K374N | aaG | aaC | 8 | 18 | AY.5 | 0.000165 |
N | 374 | K374N | aaG | aaT | 11 | 16 | AY.3 | 0.000109 |
N | 374 | K374N | aaG | aaC | 5 | 16 | AY.3 | 0.00005 |
N | 374 | K374N | aaG | aaC | 11 | 16 | B.1 | 0.000101 |
N | 374 | K374N | aaG | aaT | 5 | 16 | B.1 | 0.000046 |
N | 374 | K374N | aaG | aaT | 10 | 12 | P.1 | 0.000158 |
N | 374 | K374N | aaG | aaC | 2 | 12 | P.1 | 0.000032 |
N | 374 | K374N | aaG | aaT | 7 | 11 | AY.42 | 0.000282 |
N | 374 | K374N | aaG | aaC | 4 | 11 | AY.42 | 0.000161 |
N | 374 | K374N | aaG | aaC | 9 | 10 | AY.29 | 0.000142 |
N | 374 | K374N | aaG | aaT | 1 | 10 | AY.29 | 0.000016 |
N | 374 | K374N | aaG | aaT | 4 | 7 | AY.39 | 0.000099 |
N | 374 | K374N | aaG | aaC | 3 | 7 | AY.39 | 0.000074 |
N | 374 | K374N | aaG | aaC | 4 | 7 | AY.58 | 0.00363 |
N | 374 | K374N | aaG | aaT | 3 | 7 | AY.58 | 0.002722 |
N | 374 | K374N | aaG | aaC | 5 | 7 | B.1.617.1 | 0.000645 |
N | 374 | K374N | aaG | aaT | 2 | 7 | B.1.617.1 | 0.000258 |
N | 374 | K374N | aaG | aaT | 5 | 6 | AY.120 | 0.000186 |
N | 374 | K374N | aaG | aaC | 1 | 6 | AY.120 | 0.000037 |
N | 374 | K374N | aaG | aaC | 4 | 6 | AY.32 | 0.00213 |
N | 374 | K374N | aaG | aaT | 2 | 6 | AY.32 | 0.001065 |
N | 374 | K374N | aaG | aaC | 5 | 6 | AY.39.1 | 0.000198 |
N | 374 | K374N | aaG | aaT | 1 | 6 | AY.39.1 | 0.00004 |
N | 374 | K374N | aaG | aaC | 4 | 6 | AY.46 | 0.000416 |
N | 374 | K374N | aaG | aaT | 2 | 6 | AY.46 | 0.000208 |
N | 374 | K374N | aaG | aaT | 5 | 6 | AY.95 | 0.003805 |
N | 374 | K374N | aaG | aaC | 1 | 6 | AY.95 | 0.000761 |
N | 374 | K374N | aaG | aaT | 5 | 5 | AY.100 | 0.00023 |
N | 374 | K374N | aaG | aaT | 5 | 5 | AY.37 | 0.00158 |
N | 374 | K374N | aaG | aaC | 4 | 5 | AY.6 | 0.000165 |
N | 374 | K374N | aaG | aaT | 1 | 5 | AY.6 | 0.000041 |
N | 374 | K374N | aaG | aaT | 5 | 5 | AY.8 | 0.00303 |
N | 374 | K374N | aaG | aaT | 5 | 5 | AY.9 | 0.000338 |
N | 374 | K374N | aaG | aaT | 5 | 5 | B.1.1.222 | 0.00102 |
N | 374 | K374N | aaG | aaT | 4 | 5 | B.1.526 | 0.000094 |
N | 374 | K374N | aaG | aaC | 1 | 5 | B.1.526 | 0.000024 |
N | 374 | K374N | aaG | aaC | 3 | 5 | B.1.621 | 0.000266 |
N | 374 | K374N | aaG | aaT | 2 | 5 | B.1.621 | 0.000177 |
N | 374 | K374N | aaG | aaT | 4 | 4 | AY.1 | 0.001583 |
N | 374 | K374N | aaG | aaT | 4 | 4 | AY.23 | 0.000279 |
N | 374 | K374N | aaG | aaT | 3 | 4 | AY.98.1 | 0.000145 |
N | 374 | K374N | aaG | aaC | 1 | 4 | AY.98.1 | 0.000048 |
N | 374 | K374N | aaG | aaT | 4 | 4 | B.1.1.176 | 0.001757 |
N | 374 | K374N | aaG | aaT | 4 | 4 | B.1.1.348 | 0.003185 |
N | 374 | K374N | aaG | aaT | 4 | 4 | B.1.1.433 | 0.005698 |
N | 374 | K374N | aaG | aaC | 3 | 4 | B.1.177 | 0.00004 |
N | 374 | K374N | aaG | aaT | 1 | 4 | B.1.177 | 0.000013 |
N | 374 | K374N | aaG | aaT | 4 | 4 | B.1.232 | 0.002149 |
N | 374 | K374N | aaG | aaC | 2 | 4 | B.1.351 | 0.000059 |
N | 374 | K374N | aaG | aaT | 2 | 4 | B.1.351 | 0.000059 |
N | 374 | K374N | aaG | aaT | 4 | 4 | B.1.369 | 0.001141 |
N | 374 | K374N | aaG | aaC | 4 | 4 | B.1.466.1 | 0.028777 |
N | 374 | K374N | aaG | aaT | 2 | 4 | B.1.525 | 0.000226 |
N | 374 | K374N | aaG | aaC | 2 | 4 | B.1.525 | 0.000226 |
N | 374 | K374N | aaG | aaC | 4 | 4 | P.1.17 | 0.000647 |
N | 374 | K374N | aaG | aaT | 4 | 4 | Q.8 | 0.00066 |
N | 374 | K374N | aaG | aaC | 2 | 3 | AY.27 | 0.000129 |
N | 374 | K374N | aaG | aaT | 1 | 3 | AY.27 | 0.000065 |
N | 374 | K374N | aaG | aaC | 2 | 3 | AY.34.1 | 0.00102 |
N | 374 | K374N | aaG | aaT | 1 | 3 | AY.34.1 | 0.00051 |
N | 374 | K374N | aaG | aaT | 3 | 3 | AY.46.5 | 0.000595 |
N | 374 | K374N | aaG | aaT | 3 | 3 | B.1.160.28 | 0.008772 |
N | 374 | K374N | aaG | aaT | 3 | 3 | B.1.177.81 | 0.000568 |
N | 374 | K374N | aaG | aaC | 2 | 3 | B.1.36 | 0.000292 |
N | 374 | K374N | aaG | aaT | 1 | 3 | B.1.36 | 0.000146 |
N | 374 | K374N | aaG | aaT | 3 | 3 | B.1.391 | 0.003382 |
N | 374 | K374N | aaG | aaT | 3 | 3 | B.1.429 | 0.000071 |
N | 374 | K374N | aaG | aaT | 3 | 3 | P.1.14 | 0.000143 |
N | 374 | K374N | aaG | aaT | 2 | 2 | AY.114 | 0.000462 |
N | 374 | K374N | aaG | aaT | 2 | 2 | AY.120.2 | 0.002571 |
N | 374 | K374N | aaG | aaC | 2 | 2 | AY.24 | 0.000862 |
N | 374 | K374N | aaG | aaT | 2 | 2 | AY.26 | 0.000057 |
N | 374 | K374N | aaG | aaT | 2 | 2 | AY.45 | 0.000243 |
N | 374 | K374N | aaG | aaC | 1 | 2 | AY.5.3 | 0.000337 |
N | 374 | K374N | aaG | aaT | 1 | 2 | AY.5.3 | 0.000337 |
N | 374 | K374N | aaG | aaT | 2 | 2 | AY.50 | 0.001599 |
N | 374 | K374N | aaG | aaT | 2 | 2 | AY.61 | 0.00021 |
N | 374 | K374N | aaG | aaT | 1 | 2 | AY.7.1 | 0.000113 |
N | 374 | K374N | aaG | aaC | 1 | 2 | AY.7.1 | 0.000113 |
N | 374 | K374N | aaG | aaT | 2 | 2 | AY.75 | 0.000112 |
N | 374 | K374N | aaG | aaT | 2 | 2 | AY.79 | 0.002421 |
N | 374 | K374N | aaG | aaT | 2 | 2 | AY.9.2 | 0.000073 |
N | 374 | K374N | aaG | aaC | 1 | 2 | AY.98 | 0.000079 |
N | 374 | K374N | aaG | aaT | 1 | 2 | AY.98 | 0.000079 |
N | 374 | K374N | aaG | aaC | 1 | 2 | B | 0.000128 |
N | 374 | K374N | aaG | aaT | 1 | 2 | B | 0.000128 |
N | 374 | K374N | aaG | aaT | 2 | 2 | B.1.1.214 | 0.000111 |
N | 374 | K374N | aaG | aaT | 2 | 2 | B.1.1.217 | 0.007273 |
N | 374 | K374N | aaG | aaC | 2 | 2 | B.1.1.351 | 0.005587 |
N | 374 | K374N | aaG | aaT | 2 | 2 | B.1.1.464 | 0.002946 |
N | 374 | K374N | aaG | aaC | 2 | 2 | B.1.160.24 | 0.00885 |
N | 374 | K374N | aaG | aaC | 2 | 2 | B.1.210 | 0.004264 |
N | 374 | K374N | aaG | aaT | 2 | 2 | B.1.36.8 | 0.002 |
N | 374 | K374N | aaG | aaT | 2 | 2 | B.1.599 | 0.007299 |
N | 374 | K374N | aaG | aaT | 2 | 2 | C.37 | 0.000232 |
N | 374 | K374N | aaG | aaT | 2 | 2 | P.1.15 | 0.000465 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AD.2 | 0.000219 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.117 | 0.000085 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.121 | 0.000135 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.14 | 0.000088 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.16 | 0.00038 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.16.1 | 0.00047 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.17 | 0.008197 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.3.1 | 0.000085 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.35 | 0.000233 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.4.1 | 0.000737 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.41 | 0.000294 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.46.1 | 0.001027 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.46.6 | 0.000072 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.59 | 0.00053 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.62 | 0.000436 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.64 | 0.000595 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.7 | 0.000196 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.84 | 0.000437 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.87 | 0.000833 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.9.1 | 0.000084 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.90 | 0.000684 |
N | 374 | K374N | aaG | aaT | 1 | 1 | AY.96 | 0.002075 |
N | 374 | K374N | aaG | aaC | 1 | 1 | AY.99.2 | 0.000092 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.1.10 | 0.001115 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.1.101 | 0.01 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.1.153 | 0.001095 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.1.284 | 0.000107 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.1.353 | 0.020833 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.1.44 | 0.00241 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.110.3 | 0.000718 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.111 | 0.001175 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.146 | 0.004237 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.160.12 | 0.00641 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.177.82 | 0.000477 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.234 | 0.000132 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.243 | 0.00007 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.252 | 0.006623 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.258 | 0.000067 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.258.16 | 0.001637 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.258.20 | 0.015873 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.258.7 | 0.001912 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.305 | 0.002151 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.324 | 0.001605 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.356 | 0.001727 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.36.22 | 0.001208 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.396 | 0.000706 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.426 | 0.001009 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.452 | 0.013699 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.466.2 | 0.000391 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.508 | 0.025641 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.561 | 0.000397 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.595 | 0.000261 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.596 | 0.000087 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.1.619 | 0.000871 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.1.94 | 0.027027 |
N | 374 | K374N | aaG | aaT | 1 | 1 | B.11 | 0.005128 |
N | 374 | K374N | aaG | aaC | 1 | 1 | B.49 | 0.05 |
N | 374 | K374N | aaG | aaC | 1 | 1 | C.30.1 | 0.006711 |
N | 374 | K374N | aaG | aaT | 1 | 1 | P.1.4 | 0.000977 |
N | 374 | K374N | aaG | aaT | 1 | 1 | P.2 | 0.000187 |
CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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