CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = N : Mut = G175R

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
N	175	G175R		nonsyn	Ggg	Agg	20	17	0.85	28796-28798
N	175	G175R		nonsyn	Ggg	Cgg	20	3	0.15	28796-28798

Details of the mutation G175R within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
N	175	G175R	Ggg	Agg	17	20	All	0.000003
N	175	G175R	Ggg	Cgg	3	20	All	0.000001
N	175	G175R	Ggg	Agg	6	7	B.1.1.7	0.000005
N	175	G175R	Ggg	Cgg	1	7	B.1.1.7	0.000001
N	175	G175R	Ggg	Agg	2	2	AY.44	0.000012
N	175	G175R	Ggg	Agg	2	2	B.1.2	0.000018
N	175	G175R	Ggg	Agg	1	1	AY.27	0.000065
N	175	G175R	Ggg	Agg	1	1	AY.4	0.000002
N	175	G175R	Ggg	Agg	1	1	AY.9.2	0.000037
N	175	G175R	Ggg	Agg	1	1	AY.98	0.000079
N	175	G175R	Ggg	Cgg	1	1	B.1	0.000009
N	175	G175R	Ggg	Cgg	1	1	B.1.1	0.000018
N	175	G175R	Ggg	Agg	1	1	B.1.221	0.000071
N	175	G175R	Ggg	Agg	1	1	B.1.351	0.00003
N	175	G175R	Ggg	Agg	1	1	C.35	0.000774

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.