CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = N : Mut = D401V

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
N	401	D401V		nonsyn	gAt	gTt	13	9	0.692308	29474-29476
N	401	D401V		nonsyn	gAT	gTC	13	3	0.230769	29474-29476
N	401	D401V		nonsyn	gAT	gTG	13	1	0.0769231	29474-29476

Details of the mutation D401V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
N	401	D401V	gAt	gTt	9	13	All	0.000002
N	401	D401V	gAT	gTC	3	13	All	0.000001
N	401	D401V	gAT	gTG	1	13	All	0
N	401	D401V	gAt	gTt	2	2	AY.4	0.000003
N	401	D401V	gAT	gTC	2	2	B.1	0.000018
N	401	D401V	gAt	gTt	2	2	B.1.565	0.001621
N	401	D401V	gAt	gTt	1	1	AY.44	0.000006
N	401	D401V	gAt	gTt	1	1	AY.47	0.000031
N	401	D401V	gAt	gTt	1	1	AY.6	0.000041
N	401	D401V	gAT	gTC	1	1	B.1.1.7	0.000001
N	401	D401V	gAt	gTt	1	1	B.1.429	0.000024
N	401	D401V	gAT	gTG	1	1	B.1.617.1	0.000129
N	401	D401V	gAt	gTt	1	1	B.1.617.2	0.000004

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.