CoV-GLUE | Mutations | Mutation
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
N | 378 | E378Q | nonsyn | Gaa | Caa | 4859 | 4857 | 0.999588 | 29405-29407 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
N | 378 | E378Q | Gaa | Caa | 4857 | 4859 | All | 0.000929 |
N | 378 | E378Q | Gaa | Caa | 2083 | 2083 | B.1.596 | 0.181509 |
N | 378 | E378Q | Gaa | Caa | 1100 | 1100 | B.1.2 | 0.009686 |
N | 378 | E378Q | Gaa | Caa | 568 | 569 | B.1.1.7 | 0.000508 |
N | 378 | E378Q | Gaa | Caa | 120 | 120 | C.38 | 0.967742 |
N | 378 | E378Q | Gaa | Caa | 117 | 117 | B.1 | 0.001072 |
N | 378 | E378Q | Gaa | Caa | 96 | 96 | B.1.243 | 0.00668 |
N | 378 | E378Q | Gaa | Caa | 75 | 75 | B.1.1.521 | 0.40107 |
N | 378 | E378Q | Gaa | Caa | 54 | 54 | B.1.36.24 | 0.333333 |
N | 378 | E378Q | Gaa | Caa | 46 | 46 | P.1.14 | 0.002199 |
N | 378 | E378Q | Gaa | Caa | 42 | 42 | B.1.1.39 | 0.021407 |
N | 378 | E378Q | Gaa | Caa | 42 | 42 | B.1.1.519 | 0.001668 |
N | 378 | E378Q | Gaa | Caa | 35 | 35 | P.1 | 0.000551 |
N | 378 | E378Q | Gaa | Caa | 33 | 33 | B.1.1 | 0.000599 |
N | 378 | E378Q | Gaa | Caa | 25 | 25 | B.1.429 | 0.000588 |
N | 378 | E378Q | Gaa | Caa | 21 | 21 | B.1.576 | 0.019039 |
N | 378 | E378Q | Gaa | Caa | 17 | 17 | AY.4 | 0.000026 |
N | 378 | E378Q | Gaa | Caa | 16 | 16 | B.1.369 | 0.004564 |
N | 378 | E378Q | Gaa | Caa | 16 | 16 | B.1.617.2 | 0.00006 |
N | 378 | E378Q | Gaa | Caa | 15 | 15 | AY.111 | 0.002747 |
N | 378 | E378Q | Gaa | Caa | 15 | 15 | B.1.177 | 0.000198 |
N | 378 | E378Q | Gaa | Caa | 14 | 14 | A.2.5 | 0.006986 |
N | 378 | E378Q | Gaa | Caa | 13 | 13 | B.1.351 | 0.000386 |
N | 378 | E378Q | Gaa | Caa | 12 | 12 | B.1.218 | 0.061856 |
N | 378 | E378Q | Gaa | Caa | 11 | 11 | B.1.221 | 0.000781 |
N | 378 | E378Q | Gaa | Caa | 11 | 11 | B.1.88.1 | 0.052885 |
N | 378 | E378Q | Gaa | Caa | 10 | 10 | B.1.1.318 | 0.003018 |
N | 378 | E378Q | Gaa | Caa | 10 | 10 | R.1 | 0.0009 |
N | 378 | E378Q | Gaa | Caa | 9 | 9 | B.1.1.433 | 0.012821 |
N | 378 | E378Q | Gaa | Caa | 8 | 8 | P.1.2 | 0.009249 |
N | 378 | E378Q | Gaa | Caa | 7 | 7 | AY.44 | 0.000043 |
N | 378 | E378Q | Gaa | Caa | 7 | 7 | B.1.427 | 0.000353 |
N | 378 | E378Q | Gaa | Caa | 6 | 7 | B.1.466.2 | 0.002347 |
N | 378 | E378Q | Gaa | Caa | 7 | 7 | P.2 | 0.001306 |
N | 378 | E378Q | Gaa | Caa | 6 | 6 | B.1.177.60 | 0.001311 |
N | 378 | E378Q | Gaa | Caa | 6 | 6 | B.1.234 | 0.000792 |
N | 378 | E378Q | Gaa | Caa | 6 | 6 | B.1.36 | 0.000875 |
N | 378 | E378Q | Gaa | Caa | 6 | 6 | B.1.621 | 0.000531 |
N | 378 | E378Q | Gaa | Caa | 5 | 5 | AD.2 | 0.001095 |
N | 378 | E378Q | Gaa | Caa | 5 | 5 | B.1.1.28 | 0.001556 |
N | 378 | E378Q | Gaa | Caa | 5 | 5 | B.1.526 | 0.000118 |
N | 378 | E378Q | Gaa | Caa | 5 | 5 | B.1.78 | 0.042735 |
N | 378 | E378Q | Gaa | Caa | 4 | 4 | AY.42 | 0.000161 |
N | 378 | E378Q | Gaa | Caa | 4 | 4 | AY.43 | 0.000018 |
N | 378 | E378Q | Gaa | Caa | 4 | 4 | B | 0.000511 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | AY.103 | 0.000019 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | AY.25 | 0.000018 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | AY.29 | 0.000047 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | AY.59 | 0.001589 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | B.1.1.161 | 0.010601 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | B.1.1.214 | 0.000166 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | B.1.1.526 | 0.010638 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | B.1.36.29 | 0.001552 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | B.1.609 | 0.001438 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | C.37 | 0.000348 |
N | 378 | E378Q | Gaa | Caa | 3 | 3 | P.1.15 | 0.000697 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | A.2 | 0.001324 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | A.2.5.3 | 0.020619 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | AY.4.2 | 0.000043 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | AY.52 | 0.001629 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | AY.85 | 0.000854 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.1.10 | 0.00223 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.1.306 | 0.000877 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.1.33 | 0.000842 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.1.348 | 0.001592 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.1.377 | 0.002762 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.1.63 | 0.000772 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.160 | 0.000062 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.177.73 | 0.001133 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.258 | 0.000133 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.258.3 | 0.00335 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.36.1 | 0.002281 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.36.10 | 0.009569 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.36.8 | 0.002 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.620 | 0.001892 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.621.1 | 0.001012 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | B.1.637 | 0.000146 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | C.16 | 0.002121 |
N | 378 | E378Q | Gaa | Caa | 2 | 2 | C.36 | 0.001821 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.11 | 0.001339 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.117 | 0.000085 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.119 | 0.000035 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.120 | 0.000037 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.20 | 0.000039 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.26 | 0.000028 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.3 | 0.00001 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.39 | 0.000025 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.54 | 0.000095 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.75 | 0.000056 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.93 | 0.000273 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | AY.99.2 | 0.000092 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.1 | 0.000327 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.121 | 0.002427 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.216 | 0.00089 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.222 | 0.000204 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.25 | 0.000569 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.266 | 0.012195 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.273 | 0.006757 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.285 | 0.006536 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.305 | 0.003861 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.37 | 0.000193 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.411 | 0.014706 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.434 | 0.000349 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.456 | 0.055556 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.528 | 0.004808 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.1.54 | 0.003021 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.103 | 0.019231 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.149 | 0.003425 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.177.21 | 0.000076 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.177.43 | 0.001477 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.177.45 | 0.000381 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.177.7 | 0.000165 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.177.81 | 0.000189 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.222 | 0.001692 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.240 | 0.000216 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.258.17 | 0.000104 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.305 | 0.002151 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.311 | 0.000275 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.325 | 0.006897 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.36.16 | 0.001425 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.367 | 0.000792 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.370 | 0.008 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.396 | 0.000706 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.406 | 0.006061 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.416.1 | 0.001563 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.438.1 | 0.000107 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.462 | 0.007246 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.470 | 0.001404 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.509 | 0.000866 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.525 | 0.000113 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.560 | 0.00463 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.565 | 0.00081 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.575 | 0.000303 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.577 | 0.000687 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | B.1.9.5 | 0.005682 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | C.35 | 0.000774 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | C.36.3 | 0.000567 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | D.2 | 0.000075 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | P.1.17 | 0.000162 |
N | 378 | E378Q | Gaa | Caa | 1 | 1 | P.1.7 | 0.000319 |
CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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