CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = M : Mut = S214I
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| M | 214 | S214I | nonsyn | aGt | aTt | 1002 | 1002 | 1 | 27162-27164 |
Details of the mutation S214I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| M | 214 | S214I | aGt | aTt | 1002 | 1002 | All | 0.000192 |
| M | 214 | S214I | aGt | aTt | 232 | 232 | B.1.1.7 | 0.000208 |
| M | 214 | S214I | aGt | aTt | 101 | 101 | AY.4 | 0.000157 |
| M | 214 | S214I | aGt | aTt | 73 | 73 | B.1.617.2 | 0.000275 |
| M | 214 | S214I | aGt | aTt | 60 | 60 | AY.43 | 0.000266 |
| M | 214 | S214I | aGt | aTt | 57 | 57 | AY.3.1 | 0.00486 |
| M | 214 | S214I | aGt | aTt | 56 | 56 | AY.25 | 0.000337 |
| M | 214 | S214I | aGt | aTt | 31 | 31 | AY.121 | 0.004195 |
| M | 214 | S214I | aGt | aTt | 30 | 30 | B.1.2 | 0.000264 |
| M | 214 | S214I | aGt | aTt | 28 | 28 | B.1 | 0.000256 |
| M | 214 | S214I | aGt | aTt | 20 | 20 | AY.103 | 0.000124 |
| M | 214 | S214I | aGt | aTt | 16 | 16 | B.1.554 | 0.070485 |
| M | 214 | S214I | aGt | aTt | 12 | 12 | AY.3 | 0.000119 |
| M | 214 | S214I | aGt | aTt | 10 | 10 | AY.106 | 0.003349 |
| M | 214 | S214I | aGt | aTt | 10 | 10 | AY.44 | 0.000061 |
| M | 214 | S214I | aGt | aTt | 10 | 10 | B.1.243 | 0.000696 |
| M | 214 | S214I | aGt | aTt | 9 | 9 | AY.39 | 0.000222 |
| M | 214 | S214I | aGt | aTt | 9 | 9 | B.1.160 | 0.000281 |
| M | 214 | S214I | aGt | aTt | 8 | 8 | AY.33 | 0.000534 |
| M | 214 | S214I | aGt | aTt | 8 | 8 | B.1.177 | 0.000105 |
| M | 214 | S214I | aGt | aTt | 8 | 8 | P.1 | 0.000126 |
| M | 214 | S214I | aGt | aTt | 7 | 7 | AY.39.1 | 0.000277 |
| M | 214 | S214I | aGt | aTt | 7 | 7 | AY.42 | 0.000282 |
| M | 214 | S214I | aGt | aTt | 7 | 7 | AY.48 | 0.003256 |
| M | 214 | S214I | aGt | aTt | 7 | 7 | B.1.1 | 0.000127 |
| M | 214 | S214I | aGt | aTt | 7 | 7 | P.1.14 | 0.000335 |
| M | 214 | S214I | aGt | aTt | 6 | 6 | AY.26 | 0.00017 |
| M | 214 | S214I | aGt | aTt | 6 | 6 | AY.75 | 0.000336 |
| M | 214 | S214I | aGt | aTt | 6 | 6 | AY.99 | 0.006296 |
| M | 214 | S214I | aGt | aTt | 6 | 6 | B.1.565 | 0.004862 |
| M | 214 | S214I | aGt | aTt | 5 | 5 | AY.100 | 0.00023 |
| M | 214 | S214I | aGt | aTt | 5 | 5 | AY.20 | 0.000194 |
| M | 214 | S214I | aGt | aTt | 5 | 5 | AY.29 | 0.000079 |
| M | 214 | S214I | aGt | aTt | 5 | 5 | AY.5 | 0.000103 |
| M | 214 | S214I | aGt | aTt | 5 | 5 | AY.64 | 0.002976 |
| M | 214 | S214I | aGt | aTt | 4 | 4 | AY.102 | 0.000106 |
| M | 214 | S214I | aGt | aTt | 4 | 4 | AY.23 | 0.000279 |
| M | 214 | S214I | aGt | aTt | 4 | 4 | AY.45 | 0.000487 |
| M | 214 | S214I | aGt | aTt | 4 | 4 | B.1.199 | 0.016529 |
| M | 214 | S214I | aGt | aTt | 4 | 4 | B.1.429 | 0.000094 |
| M | 214 | S214I | aGt | aTt | 4 | 4 | B.1.526 | 0.000094 |
| M | 214 | S214I | aGt | aTt | 4 | 4 | C.37 | 0.000464 |
| M | 214 | S214I | aGt | aTt | 3 | 3 | AY.4.2 | 0.000065 |
| M | 214 | S214I | aGt | aTt | 3 | 3 | AY.98.1 | 0.000145 |
| M | 214 | S214I | aGt | aTt | 3 | 3 | B.1.320 | 0.003736 |
| M | 214 | S214I | aGt | aTt | 3 | 3 | B.1.349 | 0.002144 |
| M | 214 | S214I | aGt | aTt | 3 | 3 | B.1.351 | 0.000089 |
| M | 214 | S214I | aGt | aTt | 3 | 3 | B.1.617.1 | 0.000387 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | AY.118 | 0.000125 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | AY.37 | 0.000632 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | AY.6 | 0.000082 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | AY.94 | 0.000885 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | B | 0.000256 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | B.1.1.519 | 0.000079 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | B.1.177.86 | 0.000367 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | B.1.36 | 0.000292 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | B.1.36.29 | 0.001035 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | B.1.396 | 0.001411 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | B.1.517 | 0.000854 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | B.1.637 | 0.000146 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | B.6 | 0.00182 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | D.2 | 0.00015 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | Q.1 | 0.000253 |
| M | 214 | S214I | aGt | aTt | 2 | 2 | R.1 | 0.00018 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | A.2.4 | 0.003367 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.111 | 0.000183 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.119 | 0.000035 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.16 | 0.00038 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.23.1 | 0.000417 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.27 | 0.000065 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.32 | 0.000532 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.35 | 0.000233 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.4.5 | 0.000107 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.46.5 | 0.000198 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.46.6 | 0.000072 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.5.3 | 0.000337 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.53 | 0.000288 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.61 | 0.000105 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.62 | 0.000436 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.66 | 0.00107 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.68 | 0.000274 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.7.1 | 0.000113 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.74 | 0.000116 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.9 | 0.000068 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.9.2 | 0.000037 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.93 | 0.000273 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AY.98 | 0.000079 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | AZ.2 | 0.000821 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.1.214 | 0.000055 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.1.318 | 0.000302 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.1.388 | 0.045455 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.1.420 | 0.001006 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.1.526 | 0.003546 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.139 | 0.000733 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.149 | 0.003425 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.177.57 | 0.000281 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.189 | 0.004292 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.210 | 0.002132 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.221 | 0.000071 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.351.2 | 0.000303 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.351.3 | 0.000876 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.36.10 | 0.004785 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.36.31 | 0.001751 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.367 | 0.000792 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.398 | 0.002976 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.400 | 0.000429 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.466.2 | 0.000391 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.499 | 0.00105 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.524 | 0.001406 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.602 | 0.006536 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | B.1.630 | 0.005236 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | C.36.3 | 0.000567 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | C.36.3.1 | 0.002717 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | N.3 | 0.005814 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | P.1.15 | 0.000232 |
| M | 214 | S214I | aGt | aTt | 1 | 1 | P.4 | 0.003802 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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