CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = M : Mut = L129G

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
M	129	L129G		nonsyn	CTG	GGT	26	11	0.423077	26907-26909
M	129	L129G		nonsyn	CTg	GGg	26	8	0.307692	26907-26909
M	129	L129G		nonsyn	CTG	GGC	26	6	0.230769	26907-26909
M	129	L129G		nonsyn	CTG	GGA	26	1	0.0384615	26907-26909

Details of the mutation L129G within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
M	129	L129G	CTG	GGT	11	26	All	0.000002
M	129	L129G	CTg	GGg	8	26	All	0.000002
M	129	L129G	CTG	GGC	6	26	All	0.000001
M	129	L129G	CTG	GGA	1	26	All	0
M	129	L129G	CTG	GGT	8	20	B.1.1.7	0.000007
M	129	L129G	CTg	GGg	6	20	B.1.1.7	0.000005
M	129	L129G	CTG	GGC	5	20	B.1.1.7	0.000004
M	129	L129G	CTG	GGA	1	20	B.1.1.7	0.000001
M	129	L129G	CTG	GGT	2	4	B.1	0.000018
M	129	L129G	CTg	GGg	1	4	B.1	0.000009
M	129	L129G	CTG	GGC	1	4	B.1	0.000009
M	129	L129G	CTg	GGg	1	2	B.1.1	0.000018
M	129	L129G	CTG	GGT	1	2	B.1.1	0.000018

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.