CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = M : Mut = L129A

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
M	129	L129A		nonsyn	CTG	GCT	76	36	0.473684	26907-26909
M	129	L129A		nonsyn	CTg	GCg	76	31	0.407895	26907-26909
M	129	L129A		nonsyn	CTG	GCC	76	5	0.0657895	26907-26909
M	129	L129A		nonsyn	CTG	GCA	76	4	0.0526316	26907-26909

Details of the mutation L129A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
M	129	L129A	CTG	GCT	36	76	All	0.000007
M	129	L129A	CTg	GCg	31	76	All	0.000006
M	129	L129A	CTG	GCC	5	76	All	0.000001
M	129	L129A	CTG	GCA	4	76	All	0.000001
M	129	L129A	CTG	GCT	30	61	B.1.1.7	0.000027
M	129	L129A	CTg	GCg	26	61	B.1.1.7	0.000023
M	129	L129A	CTG	GCC	3	61	B.1.1.7	0.000003
M	129	L129A	CTG	GCA	2	61	B.1.1.7	0.000002
M	129	L129A	CTG	GCT	2	4	B.1	0.000018
M	129	L129A	CTg	GCg	1	4	B.1	0.000009
M	129	L129A	CTG	GCC	1	4	B.1	0.000009
M	129	L129A	CTG	GCA	1	3	P.1	0.000016
M	129	L129A	CTg	GCg	1	3	P.1	0.000016
M	129	L129A	CTG	GCT	1	3	P.1	0.000016
M	129	L129A	CTG	GCT	1	2	AY.25	0.000006
M	129	L129A	CTG	GCA	1	2	AY.25	0.000006
M	129	L129A	CTG	GCT	1	2	B.1.1	0.000018
M	129	L129A	CTg	GCg	1	2	B.1.1	0.000018
M	129	L129A	CTg	GCg	1	2	B.1.576	0.000907
M	129	L129A	CTG	GCT	1	2	B.1.576	0.000907
M	129	L129A	CTg	GCg	1	1	AY.103	0.000006
M	129	L129A	CTG	GCC	1	1	AY.113	0.000142

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.