CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = M : Mut = D190E

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
M	190	D190E		nonsyn	gaC	gaA	205	200	0.97561	27090-27092
M	190	D190E		nonsyn	gaC	gaG	205	5	0.0243902	27090-27092

Details of the mutation D190E within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
M	190	D190E	gaC	gaA	200	205	All	0.000038
M	190	D190E	gaC	gaG	5	205	All	0.000001
M	190	D190E	gaC	gaA	88	88	AY.47	0.002737
M	190	D190E	gaC	gaA	41	41	AY.4	0.000064
M	190	D190E	gaC	gaA	18	18	B.1.1.7	0.000016
M	190	D190E	gaC	gaA	8	10	B.1.617.2	0.00003
M	190	D190E	gaC	gaG	2	10	B.1.617.2	0.000008
M	190	D190E	gaC	gaA	5	5	AY.42	0.000201
M	190	D190E	gaC	gaA	4	4	AY.44	0.000024
M	190	D190E	gaC	gaA	4	4	AY.61	0.000419
M	190	D190E	gaC	gaA	3	3	P.1	0.000047
M	190	D190E	gaC	gaA	2	2	AY.102	0.000053
M	190	D190E	gaC	gaA	2	2	AY.119	0.000071
M	190	D190E	gaC	gaA	2	2	AY.120	0.000074
M	190	D190E	gaC	gaA	2	2	AY.25	0.000012
M	190	D190E	gaC	gaA	2	2	AY.4.2.1	0.000298
M	190	D190E	gaC	gaA	2	2	AY.45	0.000243
M	190	D190E	gaC	gaG	2	2	B.1.36.18	0.00084
M	190	D190E	gaC	gaA	2	2	B.1.429	0.000047
M	190	D190E	gaC	gaA	2	2	B.1.621	0.000177
M	190	D190E	gaC	gaA	1	1	AY.100	0.000046
M	190	D190E	gaC	gaA	1	1	AY.14	0.000088
M	190	D190E	gaC	gaA	1	1	AY.39	0.000025
M	190	D190E	gaC	gaA	1	1	AY.43	0.000004
M	190	D190E	gaC	gaG	1	1	AY.54	0.000095
M	190	D190E	gaC	gaA	1	1	AY.55	0.000917
M	190	D190E	gaC	gaA	1	1	AY.7	0.000196
M	190	D190E	gaC	gaA	1	1	AY.7.1	0.000113
M	190	D190E	gaC	gaA	1	1	AY.74	0.000116
M	190	D190E	gaC	gaA	1	1	AY.92	0.000287
M	190	D190E	gaC	gaA	1	1	B.1	0.000009
M	190	D190E	gaC	gaA	1	1	B.1.258	0.000067
M	190	D190E	gaC	gaA	1	1	B.1.466.2	0.000391
M	190	D190E	gaC	gaA	1	1	C.37	0.000116

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.